The growth of co-transformed cells in the peritoneal cavity alters their cellular gene expression to mirror that of PEL biopsies. by Mitchell Hayes (5334887)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Brain regions (ROIs) showing significantly increased ReHo in StD group (decreased ReHo in NC) (two sample <i>t</i>-test, thresholded at <i>p</i><0.005 with an extent threshold 5 co... by Zhenling Ma (290924)

Nrf2 is necessary for optimal PMN migration toward CXCL12 and CXCL2 without regulating receptors expression. by Doumet Georges Helou (7255823)

Semi-log plot of the total number of medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of i... by Marcel Ausloos (748325)

Semi-log plot of the number of Gold medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of im... by Marcel Ausloos (748325)

Comparison (in percent) of annual heat production per square meter of installed collector for several representative solar-thermal systems: a) evacuated tube to flat-plate, b) conc... by Zack Norwood (669273)

(A) Growth of <i>M</i>. <i>smegmatis ΔFtsEX</i> cells with rifampicin [350 μg/ml] with the time interval between consecutive microdialysis steps doubled to 2 hours—across the various microdialyser growth chambers sizes—1700pL (red curves), 1200pL (green), 500pL (blue) and 200pL (black).... by Brilliant B. Luthuli (785964)

Fatal autoimmune disorder in mice with T_reg cell–specific disruption of <i>miR-142</i>. by Wei-Le Wang (133402)

Relationship between drug effects on animations task performance and emotion recognition performance. by Bianca A. Schuster (18824561)

Items. by Samuel W. Terman (13584382)

“…<div><p>Epilepsy is a common, serious condition. Fortunately, seizure risk decreases with increasing seizure-free time on antiseizure medications (ASMs). …”

Survey feedback. by Samuel W. Terman (13584382)

“…<div><p>Epilepsy is a common, serious condition. Fortunately, seizure risk decreases with increasing seizure-free time on antiseizure medications (ASMs). …”

S2 Table - by Penny A. Rudd (10298691)

Explanatory power in short period samples. by Mihály Ormos (697939)

Molluscicidal activity and physiological toxicity of quaternary benzo[c]phenanthridine alkaloids (QBAs) from <i>Macleaya cordata</i> fruits on <i>Oncomelania hupensis</i> by Wenshan Ke (7490798)

“…We sought to identify a high-efficiency biogenic molluscicide against <i>Oncomelania</i> with low toxicity, to avoid chemical molluscicide contamination and toxicity in aquatic organisms. …”

Explanatory power of risk measures in bullish sample. by Mihály Ormos (697939)

Explanatory power of risk measures in bearish sample. by Mihály Ormos (697939)