An Atypical Mitochondrial Carrier That Mediates Drug Action in <i>Trypanosoma brucei</i> by Juan P. de Macêdo (735541)

“…In addition, down-regulation of TbMCP14 protected bloodstream form mitochondria from a drug-induced decrease in mitochondrial membrane potential. …”

Table_4_GrTCP11, a Cotton TCP Transcription Factor, Inhibits Root Hair Elongation by Down-Regulating Jasmonic Acid Pathway in Arabidopsis thaliana.XLSX by Juan Hao (135290)

“…As with the JA-deficient mutant dde2-2, the transgenic line 4-1 was insensitive to 50 μM methyl jasmonate, compared with the wild-type plants. …”

Supplementary Material for: Drug-Eluting Stent, but Not Bare Metal Stent, Accentuates the Systematic Inflammatory Response in Patients by Liu J. (3215370)

“…An increase in NF-γB binding activity and a decrease in PPAR-γ expression in MNCs were observed in the DES group, along with increases in IγB phosphorylation and p50 expression. …”

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia by Nagore I. Marín-Ramos (1600555)

“…However, the paucity of inhibitors has precluded the clinical validation of this approach. In this work we report a potent ICMT inhibitor, compound <b>3</b> [UCM-1336, IC₅₀ = 2 μM], which is selective against the other enzymes involved in the post-translational modifications of Ras. …”

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…Ginseng contains a variety of flavonol glycosides that possess diverse biological activities; however, scant information of flavonoid glycosylation was reported in ginseng. We found that panasenoside and kaempferol 3-<i>O</i>-glucoside were commonly accumulated along with cultivation years in leaves. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

DataSheet_1_Sustainable Cannabis Nutrition: Elevated root-zone phosphorus significantly increases leachate P and does not improve yield or quality.pdf by F. Mitchell Westmoreland (10357924)

“…P typically accumulates in seeds, but its partitioning in unfertilized Cannabis flowers is not well studied. Here we report the effect of increasing P (25, 50, and 75 mg P per L) in continuous liquid fertilizer on flower yield, cannabinoid concentration, leachate P, nutrient partitioning, and phosphorus use efficiency (PUE) of a high-CBD Cannabis variety. …”

Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analy... by Qinggang Yin (10052366)

“…Ginseng contains a variety of flavonol glycosides that possess diverse biological activities; however, scant information of flavonoid glycosylation was reported in ginseng. We found that panasenoside and kaempferol 3-<i>O</i>-glucoside were commonly accumulated along with cultivation years in leaves. …”

Non-CpG methylation of major satellites. by Julia Arand (155279)

“…Interestingly, on the upper strand, we also observe the main part of CpA methylation. …”

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia by Nagore I. Marín-Ramos (1600555)

“…However, the paucity of inhibitors has precluded the clinical validation of this approach. In this work we report a potent ICMT inhibitor, compound <b>3</b> [UCM-1336, IC₅₀ = 2 μM], which is selective against the other enzymes involved in the post-translational modifications of Ras. …”

DataSheet1.pdf by Alexandre Lewalle (4876933)

“…This trend suggests an increasing reliance on intracellular mechanisms (average increase ~50%), rather than on anatomical features (average decrease ~60%), to achieve compensation of pump function in the early phase of heart failure.…”

Effect of HLA-C spatial patterning on target cells on signal integration in NK cells. by Rajdeep Kaur Grewal (12563150)

“…<p>We co-localized KIR-2DL2-HLA-C complexes in a ring pattern at t = 0 in our simulations as shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010114#pcbi.1010114.g006" target="_blank">Fig 6A</a>. …”

Cobalt Hexacyanoferrate on BiVO₄ Photoanodes for Robust Water Splitting by Franziska Simone Hegner (4528177)

“…This mechanism, stemming from the adequate alignment of the energy levels, as showed by density functional theory calculations, allows <b>CoFe-PB</b> to outperform all previous catalyst/BiVO₄ junctions and, in addition, leads to noteworthy long-term stability. A bare 10–15% decrease in photocurrent was observed after more than 50 h of operation under light irradiation.…”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

Analgesic effect of a cholinergic agonist (carbachol) in a sural nerve ligation-induced hypersensitivity mouse model by Nodoka Kato (18298748)

“…In response to thermal stimulation, allodynia was observed at 50°C and hyperalgesia at 53 and 56°C 3 days after ligation. …”

Swimming training prevents coronary endothelial dysfunction in ovariectomized spontaneously hypertensive rats by E.R.G. Claudio (6509999)

“…Three-month old spontaneously hypertensive rats (SHR, n=50) were divided into four groups: sham (SH), sham plus swimming training (SSW), ovariectomized (OVX), and ovariectomized plus swimming training (OSW). …”

Oil-Resistant Underoil Superhydrophilic Metallic Foams for Lampblack Prefiltration by Junxu Chen (5324705)

“…Moreover, the coating retains its superhydrophilicity after enduring 900 friction cycles under a 500 g load or being immersed in 50 °C soapy water for 48 h. Hence, the LSH coating with great durability on metallic foam for lampblack prefiltration resulted in a 9.3% decrease in the oil absorption weight ratio after a 17-day cooking test. …”

Table_5_GrTCP11, a Cotton TCP Transcription Factor, Inhibits Root Hair Elongation by Down-Regulating Jasmonic Acid Pathway in Arabidopsis thaliana.XLSX by Juan Hao (135290)

“…As with the JA-deficient mutant dde2-2, the transgenic line 4-1 was insensitive to 50 μM methyl jasmonate, compared with the wild-type plants. …”

Genetic evaluation of growth in Polled Nellore via multi-trait models by Isabella Coutinho de Barros (5939096)

“…<p></p><p>ABSTRACT We aimed to estimate genetic parameters for growth traits of Polled Nellore beef cattle. …”