Voltage gating is intrinsic to Cx46 hemichannels by Vytas K. Verselis (53583)

“…When the extracellular solution was essentially devoid of external divalent cations, V gating at +90 mV was unaffected and loop gating at −70 mV was abolished, but application of a very large hyperpolarizing step to −160 mV caused a robust and rapid decrease in current. …”

Data Sheet 1_Redox regulation of glutamate-1-semialdehyde aminotransferase modulates the synthesis of 5-aminolevulinic acid in Arabidopsis.pdf by Neha Sinha (16927584)

“…Based on these experiments, we propose a redox-dependent structural modification of GSAAT that could lead to a decrease in the activity of the oxidized protein compared to the reduced enzyme.…”

Schematic representation of the possible effects of PARP-1 activation on mTORC1 and mTORC2 components and cell death. by Chantal Éthier (36413)

“…PAR transiently accumulates and its metabolism results in a decrease in ATP and NAD⁺ levels, while cellular AMP increases concomitantly. …”

Comprehensive transcriptome analysis and flavonoid profiling of Ginkgo leaves reveals flavonoid content alterations in day–night cycles by Jun Ni (68173)

“…A detailed analysis of individual flavonoids showed that most of their contents were decreased by various degrees. …”

Example of the rules involved in Collagen 1 turnover. by Matthieu Bouguéon (19251466)

“…<p><b>A</b>), Decrease of collagen degradation, the value of <i>token COL</i>1_<i>remodeling</i>_<i>high</i> is decreased and that of <i>COL</i>1_<i>remodeling</i>_<i>low</i> is increased; <b>B</b>), Production of collagen by activated HSCs, the rate of application of the rule is proportional to the value of <i>counter intermediate</i>_<i>step</i>. …”

Studies of changes in concentration under different perturbation scenarios. by Xu Gu (276054)

Mycolactone induces IL-1β secretion by activating the NLRP3/1 inflammasome pathway. by M. Foulon (9873663)

“…<p>Three known inhibitors of the inflammasome pathway implicated in the secretion of IL-1β were added to LPS-stimulated BMDM cultures in the presence of mycolactone (3 ng/mL) or CPPD (20 μg/mL). <b>A.</b> The addition of 2.5 mM or 25 mM N-acetyl-L-cysteine (NAC) decreased and totally abolished IL-1β secretion, respectively, in the presence of either mycolactone or CPPD. …”

Hysteresis in vestibular compensation simulation in forward architecture. by John Porrill (35799)

“…<p>In response to a decrease in plant gain (top plot), learning proceeds initially via LTP in the direct pathway (A) and increases VOR gain in the dark by 50% (B); the learning rate has been adjusted to give this stage a time constant of 15 min. …”

Data_Sheet_1_Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States.pdf by Ning Cao (158319)

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci by Dennis J. Hazelett (517336)

“…Identification of such enhancer variants and their potential target genes represents a preliminary step in connecting risk to disease process.…”

<i>mir-80</i>(Δ) exhibits multiple characteristics typical of DR animals. by Mehul Vora (94793)

“…Early in adult life, <i>mir-80</i>(Δ) produce a reduced number of live births per day (33% decrease, p<0.05 for Day 3; 180% increase, p<0.001 Day 4–6) and exhibit a prolonged reproductive lifespan (through Day 8 for <i>mir-80</i>(Δ) as compared to WT Day 6, p<0.001). …”

SPARC-mediated SLUG expression and promotion of melanoma cell migration is PI3K/AKT dependent. by Nina Fenouille (149658)

“…(<b>C</b>) <i>Expression of Myr-AKT protects from SLUG decrease after SPARC depletion:</i> 501mel cells were infected with a control empty adenovirus (AdCMV) or with adenovirus encoding the constitutively active mutant Myr-HA-AKT1 (AdAKT^ca) and transfected 6 hours later with 50 nM siCTRL or siSPARC for 3 days. …”

Related to Fig 4. <i>NDUFS7</i> depletion in neurons lowers the failure rate of neurotransmission at very low calcium concentrations. by Bhagaban Mallik (12459375)

“…The number of failures was counted per hundred trials in each genotype. There is a marked decrease in failure rate in motor neurons driving <i>UAS-NDUFS7[RNAi]</i>. …”

Quantitative phase imaging experimental setup and principle. by Jodie Llinares (8911040)

FANCD2 Regulates DNA Translesion Synthesis Activity. by Hwan Ki Park (360858)

“…An increased activity of polymerase eta will promote lesion-gap filling; a decreased activity of polymerase eta will inhibit lesion-gap filling. …”

General Methodology to Optimize Damping Functions to Account for Charge Penetration Effects in Electrostatic Calculations Using Multicentered Multipolar Expansions by Araken S. Werneck (2458621)

“…This methodology is based in the optimization of a damping parameter set using a two-step fast local fitting procedure and the ab initio (Hartree−Fock/6-31G** and 6-31G**+) electrostatic potential calculated in a set of concentric grid of points as reference. …”

General Methodology to Optimize Damping Functions to Account for Charge Penetration Effects in Electrostatic Calculations Using Multicentered Multipolar Expansions by Araken S. Werneck (2458621)

“…This methodology is based in the optimization of a damping parameter set using a two-step fast local fitting procedure and the ab initio (Hartree−Fock/6-31G** and 6-31G**+) electrostatic potential calculated in a set of concentric grid of points as reference. …”

Met-depleted mosquitoes exhibit metabolic defects. by Yuan Hou (767606)

Effects of treatment with mTORC1 blocker rapamycin on taste cells. by Shingo Takai (7853843)

“…<p>(A, B) Confocal images of taste organoids at day 20, cultured in conditioned medium (CM) with 20 ng/ml rapamycin plus 50 nM insulin (A) or 0 nM insulin (B). …”

Characterization of Novel Factors Involved in Swimming and Swarming Motility in <i>Salmonella enterica</i> Serovar Typhimurium by Julia Andrea Deditius (782678)