Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

<b>Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study — Supplementary material</b> by Huang Xianjun (17295394)

Delayed boosting with ALVAC-HIV/AIDSVAX B/E or AIDSVAX B/E increases V1V2-specific IgG concentration and breadth. by LaTonya D. Williams (3140490)

Magnitude-breadth of linear V2 hotspot binding response. by LaTonya D. Williams (3140490)

Experimental and Computational Insight into the Mechanism of NO Binding to Ferric Microperoxidase. The Likely Role of Tautomerization to Account for the pH Dependence by Maria Oszajca (1833010)

Subjects:

MicroRNA-451a, microRNA-34a-5p, and microRNA-221-3p as predictors of response to antidepressant treatment by Wei-Hong Kuang (5255186)

“…Eight weeks after antidepressant treatment, the patients exhibited increased miRNA-451a levels, decreased miRNA-34a-5p and miRNA-221-3p levels, and reduced HAMD scores. …”

Fig 5 - by Pierre Bauvin (18154818)

TET1 regulates the mRNA and protein expression of TNFα. by Fangfang Sun (2410654)

siRNA-mediated knock-down significantly decreases MLL fusion expression levels. by Marieke H. van der Linden (706995)

Hypoxia induced decreases in dendritic spine density, length, soma size and volume of the apical and basal branches of CA1 and CA3 pyramidal neurons. by Chun-Sing Lam (695733)

<i>Kdm6a</i> knockdown causes a female-specific decrease in <i>Rhox6</i> and <i>9</i> expression in ES cells. by Joel B. Berletch (409334)

“…<p>(A) Quantitative RT-PCR after <i>Kdm6a</i> knockdown in female PGK12.1 ES cells shows a 75% and a 52% decrease in <i>Kdm6a</i> and <i>Rhox6</i> and <i>9</i> expression, respectively. …”

Directed Evolution of RecA Variants with Enhanced Capacity for Conjugational Recombination by Taejin Kim (472963)

“…Three of the variant proteins, RecA I102L, RecA V79L and RecA E86G/C90G were characterized based on their prominence. …”

Inhibition of the V-ATPase by SidK. by Jianhua Zhao (531939)

Subjects:

Image_4_v1_Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.jpeg by Casey E. Vantucci (10528263)

“…This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. …”

Table_1_v1_Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.docx by Casey E. Vantucci (10528263)

“…This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. …”

Image_2_v1_Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.jpeg by Casey E. Vantucci (10528263)

“…This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. …”

Image_3_v1_Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.jpeg by Casey E. Vantucci (10528263)

“…This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. …”

Image_6_v1_Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.jpeg by Casey E. Vantucci (10528263)

“…This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. …”

Table_2_v1_Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma.docx by Casey E. Vantucci (10528263)

“…This overall increase correlated with a decrease in bone volume (P = 0.057) at 6 weeks post-treatment and a significant decrease in mechanical strength at 12 weeks post-treatment compared to untreated rats. …”