DataSheet_1_Protein Kinase CK1α Sustains B-Cell Receptor Signaling in Mantle Cell Lymphoma.pdf by Sabrina Manni (127813)

“…The combination of CK1α inhibition with Ibrutinib or Duvelisib synergistically increased cytotoxicity, leading to a further decrease of the activation of BCR signaling pathways. …”

Image1_Second generation androgen receptor antagonist, TQB3720 abrogates prostate cancer growth via AR/GPX4 axis activated ferroptosis.tif by Zhongqing Zhang (9317126)

“…Moreover, molecular evidence shown TQB3720 regulates downstream of AR signaling by binding AR resulting in inhibition of AR entry into the nucleus. Additional, we also proved that TQB3720 abrogates the interaction between AR and SP1 and leads to decrease GPX4 transcription.…”

Image_1_The protective role of phlorizin against lipopolysaccharide-induced acute orchitis in mice associated with changes in gut microbiota composition.JPEG by Qing Guo (317746)

“…Metagenomic analyses indicated that the abundances of Bacteroidetes, Muribaculaceae, Lactobacillaceae, uncultured bacterium f Muribaculaceae, and Lactobacillus in the PHN treatment group improved, while potential microbes that can induce intestinal diseases, including Verrucomicrobia, Epsilonbacteraeota, Akkermansiaceae, and Akkermansia decreased in the PHN treatment group.</p>Conclusion<p>Our results indicate that PHN pretreatment might alleviate orchitis by altering the composition of gut microflora, which may provide a reference for reducing the occurrence of acute orchitis in male animals.…”

Image_1_The protective role of phlorizin against lipopolysaccharide-induced acute orchitis in mice associated with changes in gut microbiota composition.JPEG by Qing Guo (317746)

“…Metagenomic analyses indicated that the abundances of Bacteroidetes, Muribaculaceae, Lactobacillaceae, uncultured bacterium f Muribaculaceae, and Lactobacillus in the PHN treatment group improved, while potential microbes that can induce intestinal diseases, including Verrucomicrobia, Epsilonbacteraeota, Akkermansiaceae, and Akkermansia decreased in the PHN treatment group.</p>Conclusion<p>Our results indicate that PHN pretreatment might alleviate orchitis by altering the composition of gut microflora, which may provide a reference for reducing the occurrence of acute orchitis in male animals.…”

The <i>Arabidopsis</i> Domain of Unknown Function 1218 (DUF1218) Containing Proteins, MODIFYING WALL LIGNIN-1 and 2 (At1g31720/MWL-1 and At4g19370/MWL-2) Function Redundantly to Al... by Ritesh Mewalal (2547931)

“…However, the double homozygous mutant, <i>mwl</i>-1/<i>mwl</i>-2, had smaller rosettes with a significant decrease in rosette fresh weight and stem height relative to the WT control at four weeks and six weeks, respectively. …”

Image3_Mitochondrial Population in Mouse Eosinophils: Ultrastructural Dynamics in Cell Differentiation and Inflammatory Diseases.pdf by Kennedy Bonjour (5490656)

“…Accumulating evidence shows that mitochondrial remodeling has an impact on immune responses, but our current understanding of the mitochondrial architecture, interactions, and morphological changes in immune cells, mainly in eosinophils, is still poorly known. Here, we applied transmission electron microscopy (TEM), single-cell imaging analysis, and electron tomography, a technique that provides three-dimensional (3D) views at high resolution, to investigate mitochondrial dynamics in mouse eosinophils developing in cultures as well as in the context of inflammatory diseases characterized by recruitment and activation of these cells (mouse models of asthma, H1N1 influenza A virus (IAV) infection, and schistosomiasis mansoni). …”

Image2_Mitochondrial Population in Mouse Eosinophils: Ultrastructural Dynamics in Cell Differentiation and Inflammatory Diseases.pdf by Kennedy Bonjour (5490656)

“…Accumulating evidence shows that mitochondrial remodeling has an impact on immune responses, but our current understanding of the mitochondrial architecture, interactions, and morphological changes in immune cells, mainly in eosinophils, is still poorly known. Here, we applied transmission electron microscopy (TEM), single-cell imaging analysis, and electron tomography, a technique that provides three-dimensional (3D) views at high resolution, to investigate mitochondrial dynamics in mouse eosinophils developing in cultures as well as in the context of inflammatory diseases characterized by recruitment and activation of these cells (mouse models of asthma, H1N1 influenza A virus (IAV) infection, and schistosomiasis mansoni). …”

Diaphragmatic function is enhanced in fatty and diabetic fatty rats by Audrey De Jong (2580097)

“…<div><p>Background</p><p>Obesity is associated with a decrease in mortality in the intensive care unit (ICU) (the "obesity paradox"). …”

EBV-Encoded LMP1 Upregulates Ig<em>κ</em> 3′Enhancer Activity and Ig<em>κ</em> Expression in Nasopharyngeal Cancer Cells by Activating the Ets-1 through ERKs Signaling by Haidan Liu (180030)

“…Suppression of endogenous <em>Ets-1</em> by small interfering RNA is accompanied by a decrease of Ig kappa light chain expression. …”

Data Sheet 1_Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites.docx by Sui Li (8872481)

“…Moreover, combination therapy led to an increase in the proportion of probiotic bacteria in the mouse gut microbiota, resulting in elevated levels of antitumor metabolites and a decrease in metabolites that affect immune cell function.…”

Table_1_Assessment of causal associations between uric acid and 25-hydroxyvitamin D levels.docx by Yingdong Han (11904761)

“…However, the causality and the direction of the associations remain unknown. Thus, we performed a two-sample bidirectional Mendelian Randomization (MR) analysis to investigate the causal association between uric acid and 25-hydroxyvitamin D and to determine the direction of the association.…”

Identifying Low pH Active and Lactate-Utilizing Taxa within Oral Microbiome Communities from Healthy Children Using Stable Isotope Probing Techniques by Jeffrey S. McLean (180306)

“…Rapid lactate utilization upon glucose depletion was observed under pH 7 conditions. SIP analyses revealed a number of genera containing cultured and uncultivated taxa with metabolic capabilities at pH 5.5. …”

Fatty Acid Solubilizer from the Oral Disk of the Blowfly by Yuko Ishida (104789)

“…The binding affinity of PregOBP56a decreased at pH 5. We propose that PregOBP56a is a protein that solubilizes fatty acids during feeding and subsequently helps to deliver the fatty acids to the midgut where it may help in the process of reproduction. …”

Phosphinimino-amino Magnesium Complexes: Synthesis and Catalysis of Heteroselective ROP of <i>rac</i>-Lactide by Hongyan Xie (264700)

“…Complexes <b>1</b>–<b>8</b> are phosphinimino-amine-ligated THF-solvated mono­(alkyl)­s, among which <b>1</b>–<b>4</b> adopt twisted tetrahedral geometries, whereas <b>5</b> contains a trigonal bipyramido geometry core. …”

Nature of the Entire Range of Rare Earth Metal-Based Cationic Catalysts for Highly Active and Syndioselective Styrene Polymerization by Fei Lin (156666)

“…The activity increased with the decrease in the rare earth metal size, in striking contrast to the literature that has shown that a large metal facilitates a high activity, which was also not a result of an enthalpic effect (Δ<i>H</i>^⧧) or an entropic effect (Δ<i>S</i>^⧧) according to Eyring plots. …”

FOXG1 interaction with SATB2 promotes autophagy to alleviate neuroinflammation and mechanical abnormal pain in rats with lumbar disc herniation by Zhanchao Wang (779221)

“…<i>L. paracasei S16</i> affects miR-31a-5p and SATB2 expression. Dual luciferase reporter gene assay confirmed that miR-31a-5p bound to SATB2. …”

Supplementary Material for: Newborn Resuscitation Training Programmes Reduce Early Neonatal Mortality by Pammi M. (4159786)

Data Paper. Data Paper by Matt G. Bradford (401438)

“…<h2>File List</h2><div> <p><a href="CSIRO_permanent_plots.zip">CSIRO_permanent_plots.zip</a> (MD5: 05f273b3cf0c52a747bd64f383f8f3a4)</p> <p><a href="CSIRO_Permanent_Rainforest_Plots_of_North_Queensland.html">CSIRO_Permanent_Rainforest_Plots_of_North_Queensland.html</a></p> </div><h2>Description</h2><div> <p>We present repeated stem measurement data from 20 0.5-ha (100 × 50 m) permanent rain forest plots in northern Queensland, Australia from 1971 to 2013. …”

Spike rate vs. <i>N</i>, the average number of vesicles released by the IHC per sound wave cycle for the 3d SNIC model. by Mark Ospeck (307276)

“…<p>The size of the data points shows the standard error in the spike rate, which increases with <i>N</i> (red; <i>gKl</i> = 8, <i>gL</i> = 5, <i>gH</i> = 1). …”

Effect of Transcatheter Closure of Secundum Atrial Septal Defect on Cardiac Electric Remodeling by Shaimaa Ahmed Mostafa (4761951)

“…At the end of follow-up, the right ventricular (RV) end-diastolic dimension decreased from 25.67 ± 5.50 mm to 17.80 ± 2.70 mm (P = 0.001) the left ventricular end-diastolic dimension increased from 33.17 ± 6.44 mm to 37.53 ± 5.15 mm (P = 0.002), mean pulmonary artery pressure decreased from 16.97 ± 3.37 mmHg to 9.22 ± 1.37 mmHg (P = 0.000), and RV systolic pressure decreased from 30.77 ± 4.69 mmHg to 18.8 ± 2.11 mmHg. …”