Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Image_1_Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma.pdf by Yue Zhao (186573)

Image_3_Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma.pdf by Yue Zhao (186573)

Image_2_Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma.pdf by Yue Zhao (186573)

Table_2_Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma.docx by Yue Zhao (186573)

Table_1_Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma.docx by Yue Zhao (186573)

Table_3_Increased Tumor Intrinsic Growth Potential and Decreased Immune Function Orchestrate the Progression of Lung Adenocarcinoma.xlsx by Yue Zhao (186573)

Adaptation to cool temperature decreases basal and stimulated lipolysis and increases <i>de novo</i> lipogenesis and TAG synthesis. by Hiroyuki Mori (512656)

“…(<b>H</b>) Quantification of autoradiography for labeled TAG was by ImageJ. <i>n =</i> 5, data are mean ± SD. *<i>p</i> < 0.05. Uncropped western blots are provided in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000988#pbio.3000988.s016" target="_blank">S1 Raw Images</a>, and numerical data for all graphs are provided in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000988#pbio.3000988.s014" target="_blank">S6 Data</a>. …”

DataSheet_1_Increased circulating regulatory T cells and decreased follicular T helper cells are associated with colorectal carcinogenesis.docx by Qiao Meng (14368167)

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of Ca_V2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca²⁺ In... by Maria Isabel Bahamonde (840859)

“…ΔF1502 strongly decreases the voltage threshold for channel activation (by ~ 21 mV), allowing significantly higher Ca²⁺ current densities in a range of depolarized voltages with physiological relevance in neurons, even though maximal Ca²⁺ current density through ΔF1502 Ca_V2.1 channels is 60% lower than through wild-type channels. …”

nsP4-C483Y or Q192L mutations decrease sensitivity to 4′-FlU. by Peiqi Yin (6533747)

A randomized trial of a behavioral intervention to decrease hospital length of stay by decreasing bedrest by Juliana Tolles (8282265)

“…Previous studies of early mobilization have demonstrated improvement in outcomes, but the interventions studied have been resource-intensive. We aimed to decrease the time hospital inpatients spend in bed through a pragmatic mobilization protocol.…”

Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis-1 by Mrigank Srivastava (94935)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…In aged HSA-mUCP1 mice, urinary MG-derived AGEs/FL ratio was decreased ca. 60% whereas there was no change in CML/FL ratio – a marker of oxidative damage. …”
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Data_Sheet_1_Physiological synchrony in electrodermal activity predicts decreased vigilant attention induced by sleep deprivation.docx by Ivo V. Stuldreher (11897870)

Positioning errors of different algorithms on the a multi-modal and multi-scenario dataset for ground robots dataset. by Hongliang Zou (20707270)

Subjects:

Specific parameters of the test sequence in the a multi-modal and multi-scenario dataset for ground robots dataset. by Hongliang Zou (20707270)

Subjects:

Table_2_Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions.PDF by Julia Swan (14556800)

Table_2_Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions.PDF by Julia Swan (14556800)

Image_1_Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions.TIFF by Julia Swan (14556800)