A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF‑7 Breast-Cancer Cells without Affecting Proliferation by Anirban Mukherjee (103177)

“…In this context, we identified a G9a/GLP degrader (<b>4</b>) based on RK-701, a less-toxic G9a/GLP-selective inhibitor. …”

HRMECs treated with 3-Deazaneplanocin A (DZNep) chemical inhibitor demonstrated increased miR-200b and decreased VEGF expression. by Michael Anthony Ruiz (726055)

“…[NG = 5mM D-glucose, HG = 25mM D-glucose, NG+DMSO = 5mM D-glucose + 0.05% DMSO, HG+DMSO = 25mM D-glucose + 0.05% DMSO, NG+DZNEP = 5mM D-glucose + 5μM DZNep, HG+DZNEP = 25mM + 5μM DZNep; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to β-actin for VEGF and U6 for miR-200b, expressed as a fold change of NG].…”

DataSheet_1_A glossy mutant in onion (Allium cepa L.) shows decreased expression of wax biosynthesis genes.docx by Tushar Kashinath Manape (16871172)

Image_5_Eliminating the VGlut2-Dependent Glutamatergic Transmission of Parvalbumin-Expressing Neurons Leads to Deficits in Locomotion and Vocalization, Decreased Pain Sensitivity,... by Diana M. Roccaro-Waldmeyer (5532074)

“…We conducted a search of the Allen Brain Atlas for regions that might co-express the genes encoding PV and VGlut2, and that might thus contribute to the manifestation of the observed phenotypes. …”

DataSheet1_Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex.docx by Wesam S. Ahmed (10170053)

DataSheet1_Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex.docx by Wesam S. Ahmed (10170053)

Innovation and night light in large and small cities. by Saul Estrin (8629173)

Image 2_Probiotic Limosilactobacillus reuteri KUB-AC5 decreases urothelial cell invasion and enhances macrophage killing of uropathogenic Escherichia coli in vitro study.tiff by Arishabhas Tantibhadrasapa (13929639)

“…The human bladder epithelial cell line UM-UC-3 was used to assess the adhesion and pathogen-attachment inhibition properties of AC5 on UPEC.</p>Results and discussion<p>Our data showed that AC5 can attach to UM-UC-3 and decrease UPEC attachment in a dose-dependent manner. …”

Table 1_Probiotic Limosilactobacillus reuteri KUB-AC5 decreases urothelial cell invasion and enhances macrophage killing of uropathogenic Escherichia coli in vitro study.xlsx by Arishabhas Tantibhadrasapa (13929639)

“…The human bladder epithelial cell line UM-UC-3 was used to assess the adhesion and pathogen-attachment inhibition properties of AC5 on UPEC.</p>Results and discussion<p>Our data showed that AC5 can attach to UM-UC-3 and decrease UPEC attachment in a dose-dependent manner. …”

Image 1_Probiotic Limosilactobacillus reuteri KUB-AC5 decreases urothelial cell invasion and enhances macrophage killing of uropathogenic Escherichia coli in vitro study.tiff by Arishabhas Tantibhadrasapa (13929639)

“…The human bladder epithelial cell line UM-UC-3 was used to assess the adhesion and pathogen-attachment inhibition properties of AC5 on UPEC.</p>Results and discussion<p>Our data showed that AC5 can attach to UM-UC-3 and decrease UPEC attachment in a dose-dependent manner. …”

Supplemental Figure 5: UAB30 decreased tumor growth in SK-NEP-1 xenografts. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies by Alicia M. Waters (9314636)

“…There was a significant decrease between the tumor : animal weight ratio between animals treated with UAB30 compared to vehicle, demonstrating that decreased animal weight was not responsible for decreased tumor growth.…”

Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor by Yujing J. Heng (1696339)

“…SWATH methodology quantified 258 proteins (using ≥2 peptides) and 5 proteins (ALBU, ANXA6, HNRPK, HSP90A, and PDIA1) were differentially expressed (<i>p</i> < 0.05, Mann–Whitney <i>U</i>). iTRAQ workflow identified 765 proteins; 354 proteins were quantified and 14 proteins (MIF, UBIQ, HXK3, ALBU, HNRPD, ST1A2, RS15A, RAP1B, CAN1, IQGA2, ST1A1, COX5A, ADDA, and UBQL1) were significantly different between the two groups of women (<i>p</i> < 0.05, Mann–Whitney <i>U</i>). …”

Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor by Yujing J. Heng (1696339)

“…SWATH methodology quantified 258 proteins (using ≥2 peptides) and 5 proteins (ALBU, ANXA6, HNRPK, HSP90A, and PDIA1) were differentially expressed (<i>p</i> < 0.05, Mann–Whitney <i>U</i>). iTRAQ workflow identified 765 proteins; 354 proteins were quantified and 14 proteins (MIF, UBIQ, HXK3, ALBU, HNRPD, ST1A2, RS15A, RAP1B, CAN1, IQGA2, ST1A1, COX5A, ADDA, and UBQL1) were significantly different between the two groups of women (<i>p</i> < 0.05, Mann–Whitney <i>U</i>). …”

Distinct effects on calcium channel activation of <i>CACNA1I</i> disease-associated amino acid substitutions A398E/V and M1425V/I. by Yousra El Ghaleb (22075892)

Subjects:

Catalytic fold of WT PARG1 C1-GAP domain for RhoA interaction. by Zen Kouchi (14898435)

Kcnk5b activity induces IP₃R-mediated Ca²⁺ release from the ER. by Xiaowen Jiang (8291814)

Bacterial intracellular survival increases <i>in vivo</i> persistence in a mouse model of urinary tract infection and decreases antibiotic efficacy. by Cristina Penaranda (433703)

Subcellular Mechanical Imaging of Erythrocytes with Optically Correlated Scanning Ion Conductance Microscopy by Yunong Wang (10358970)

“…Comparison of normal and diamide-treated red blood cells shows a significant increase in cell stiffness and a concomitant decrease in deformability, clearly demonstrating the quantitative abilities of the correlative approach taken here for stiffness measurements of intact cellular samples.…”

Intravitreal ALF-186 decreased the IRI-induced capsase-3 and NF-κB mRNA expression and affected the heat-shock response differently. by Julia Stifter (4621033)

Overview of the WeARTolerance program. by Ana Beato (20489933)

“…The quantitative results from Phase 1 demonstrated a decreasing trend in all primary outcomes. In phase 2, participants acknowledged the activities’ relevance, reported overall satisfaction with the program, and showed great enthusiasm and willingness to learn more. …”