The physical, biological, and genetic basis of myopia. by Robert Wojciechowski (399469)

“…Blue dots show SNPs whose p-values for association were between p = 10e-4 and 5e-8 in both datasets. The replication thresholds were the Bonferroni-corrected p-values for a family-wise error rate of 0.05: since the CREAM dataset contained 544 (nonindependent) SNPs that were genomewide significant in 23andMe, the Bonferroni-adjusted p-value threshold for replication was 0.05/544 = 9.2e-05 (or −log₁₀(p) = 4.037). …”

Trend of adults’ occupational physical activity levels and nutritional status over four decades in Brazil by Luiz Antonio dos Anjos (5381687)

“…Conclusions: despite the limitations of the study (the physical activity levels were estimated by declared occupation and did not consider the development/modification of labor processes), we concluded that workers in Brazil present a positive energy balance regardless of their occupational physical activity levels.…”

Data_Sheet_1_Analysis of Sour Porridge Microbiota and Improvement of Cooking Quality via Pure Culture Fermentation Using Lacticaseibacillus paracasei Strain SZ02.docx by Cheng Wang (102692)

“…<p>The microbial composition of sour porridge at different fermentation times was analyzed through high-throughput sequencing, and a pure culture fermentation process was established to optimize production process and improve the edible quality of the porridge. …”

Proposed <i>Hhex-Vegf</i> Hepatic Regulatory Pathway. by Adam S. Arterbery (846608)

“…<p><i>Hhex</i> and <i>Vegf</i> signaling modulate the commitment of DE cells toward the HE lineage. <b>A)</b> The addition of VEGFA protein to <i>Hhex</i>^<i>+/+</i> HE cells facilitated HE differentiation as indicated by increased hepatic gene marker expression (black bars). …”

Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia by April C.E. van Gennip (10993229)

“…Among individuals with diabetes, excess dementia risk decreased stepwise for a higher number of risk factors on target. …”

Table 2_Integration analysis of microRNAs as potential biomarkers in early-stage lung adenocarcinoma: the diagnostic and therapeutic significance of miR-183-3p.docx by Guodong Huang (1595956)

“…Biological functional assays showed that miR-183-3p emerged as a key regulator, promoting LUAD cell proliferation, decreasing apoptosis, and augmenting migration and invasion capabilities. …”

Supplementary Material for: Fenretinide Reduces Intestinal Mucin-2-Positive Goblet Cells in Chronic Alcohol Abuse by Melis M. (12534625)

“…<b><i>Methods:</i></b> In this study, we specifically sought to examine the effects of Fen on gut goblet cells, and expression of mucins, including <i>MUC2</i> using a 25-day Lieber-DeCarli model of chronic alcohol intake. …”

Table 1_Integration analysis of microRNAs as potential biomarkers in early-stage lung adenocarcinoma: the diagnostic and therapeutic significance of miR-183-3p.docx by Guodong Huang (1595956)

“…Biological functional assays showed that miR-183-3p emerged as a key regulator, promoting LUAD cell proliferation, decreasing apoptosis, and augmenting migration and invasion capabilities. …”

Data_Sheet_1_Polyoxidonium® Activates Cytotoxic Lymphocyte Responses Through Dendritic Cell Maturation: Clinical Effects in Breast Cancer.pdf by Catherine Alexia (8054819)

“…PO is used in the treatment and prophylaxis of diseases connected with damage to the immune system, and there is interest in testing it in antitumor therapy. We show here that PO treatment for 1 week induced positive pathological changes in 6 out of 20 patients with breast cancer, including complete response in a triple-negative patient. …”

Table 3_Integration analysis of microRNAs as potential biomarkers in early-stage lung adenocarcinoma: the diagnostic and therapeutic significance of miR-183-3p.docx by Guodong Huang (1595956)

“…Biological functional assays showed that miR-183-3p emerged as a key regulator, promoting LUAD cell proliferation, decreasing apoptosis, and augmenting migration and invasion capabilities. …”

Analysis of the Phospholipid Profile of Metaphase II Mouse Oocytes Undergoing Vitrification by Jaehun Jung (600064)

“…Several sphingomyelins (SM) including SM {d38∶3} [M+H]+ and SM {d34∶0} [M+K]+ were decreased significantly in positive ion mode. Overall, the declining trend of multiple phospholipids demonstrates that vitrification has a marked effect on phospholipid profiles of oocytes. …”

TGF-β inhibition is implicated in Norrie disease. by Suhong Xu (176802)

“…Wild-type (WT) or mutant <i>xNorrin</i> and <i>Fizzled4</i> and <i>Lrp5</i> (FL) were injected into animal poles. The expression of <i>Xnr3</i>, <i>Saimois</i>, and <i>Chordin</i> in animal caps was analyzed by RT-PCR. xNorrin R40K and xNorrin L60P showed slightly decreased and no Wnt activation, respectively. xNorrin K57N moderately increased Wnt activation. …”

DataSheet1_Monitoring the impact of the COVID-19 lockdown on air quality in Lanzhou: Implications for future control strategies.docx by Hui Liu (33624)

“…The results showed that during the epidemic lockdown period, although the concentration of SO₂ in Lanzhou decreased substantially, there was a significant increase in the concentration of O₃ (by 19.14%), followed by a gradual return to the normal level. …”

Gene Profiling of Postnatal <i>Mfrp^rd6</i> Mutant Eyes Reveals Differential Accumulation of <i>Prss56</i>, Visual Cycle and Phototransduction mRNAs by Ramani Soundararajan (651915)

“…In <i>Mfrp^rd6</i> eyes, a significant 1.5- to 2.0-fold decrease was observed among transcripts of genes linked to retinal degeneration, including those involved in visual cycle (<i>Rpe65</i>, <i>Lrat, Rgr</i>), phototransduction (<i>Pde6a</i>, <i>Guca1b</i>, <i>Rgs9</i>), and photoreceptor disc morphogenesis (<i>Rpgrip1</i> and <i>Fscn2</i>). …”

Expression levels of <i>th1</i> and <i>th2</i> mRNA at 3 dpf in <i>pink1</i> morphants untreated and treated with LGR. by Madhusmita Priyadarshini (490074)

“…A decrease in <i>th1</i> expression in the population 5,6,11 (*) in morphants (B) was observed as compared to the ctrl MO group (A). …”

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice by Hiromi Yamazaki (6291683)

“…Similar to the yeast Gcn2/Gcn1 system, AAS- or UV irradiation-induced elF2α phosphorylation was diminished in the <i>Gcn1</i>^{<i>ΔRWDBD</i>} mouse embryonic fibroblasts (MEFs), suggesting that GCN1 RWDBD is responsible for GCN2 activity. In addition, we found reduced cell proliferation and G2/M arrest accompanying a decrease in Cdk1 and Cyclin B1 in the <i>Gcn1</i>^{<i>ΔRWDBD</i>} MEFs. …”

Flow chart of research object screening. by Wenyao Xie (21567889)

“…In fully adjusted models, each 10 ng/dL increase in testosterone was associated with a 3.0% decrease in ALI (OR=0.970, 95%CI: 0.962–0.978, P < 0.001), while each 1 pg/mL increase in estradiol was associated with a 60.3% increase in ALI (OR=1.603, 95%CI: 1.318–1.949, P < 0.001). …”

Data_Sheet_1_Effects of supplemental feeding of Chinese herbal mixtures to perinatal sows on antioxidant capacity and gut microbiota of sows and their offspring piglets.ZIP by Xuelei Duan (19650700)

“…Furthermore, at the genus level, compared to those in the TRT1 group, piglets from the TRT4 group exhibited a significant decrease in relative abundance of Escherichia-Shigella, Parabacteroides, and Methanobrevivacter (p < 0.05), but a significant increase in Phascolarctobacterium (p < 0.05). …”

DataSheet1_Canadian aging and inactivity study: Spaceflight-inspired exercises during head-down tilt bedrest blunted reductions in muscle-pump but not cardiac baroreflex in older p... by Farshid Sadeghian (13835530)

“…Unlike their male counterparts, in terms of muscle-pump baroreflex, female participants had considerably decreased FTA after HDBR (p < 0.01). All groups except female control demonstrated parallel decreases in cardiac active gain and causality, while the FC demonstrated an increase in cardiac causality despite a similar decline in cardiac active gain. …”

datasheet1_Spatio-Temporal Variability of Peat CH4 and N2O Fluxes and Their Contribution to Peat GHG Budgets in Indonesian Forests and Oil Palm Plantations.docx by Erin Swails (10323518)

“…The GHG budget was also ten times higher in the secondary forest (10.2 ± 4.5) than in the primary forests (0.9 ± 3.9) on the account of a larger peat C budget and N₂O emission rate. …”