Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice by Jinbo Cheng (712740)

“…Inhibition of NLRP3 inflammasome activation by administration of MCC950, a specific inhibitor for NLRP3, decreased MIF expression and neuroinflammatory levels, and rescued the loss of TH neurons in the substantial nigra (SN). …”

Image1_Expression pattern of the fused in sarcoma gene and its contextual influence on the density-specific response of the growth hormone/insulin-like growth factor 1 axis in zig-... by Lingzhan Xue (11117426)

“…The expression of fus was predominant in the brain and exhibited sexual dimorphism in the brain, muscle, and liver of zig-zag eels. We found that microRNA (miR)-146-5p, miR-489-3p, and 24 other miRNAs were targeted to the fus 3′ untranslated region, which might affect muscle and bone development in adults. …”

image_2_Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants.jpeg by Oded Heyman (5139533)

“…Human studies have suggested that the frequencies of Langerhans cells (LCs), the main antigen-presenting cells (APCs) of the oral epithelium, are dysregulated around the implants. Since LCs play a role in regulating oral mucosal homeostasis, we studied the impact of dental titanium implants on LC differentiation using a novel murine model. …”

image_1_Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants.jpeg by Oded Heyman (5139533)

“…Human studies have suggested that the frequencies of Langerhans cells (LCs), the main antigen-presenting cells (APCs) of the oral epithelium, are dysregulated around the implants. Since LCs play a role in regulating oral mucosal homeostasis, we studied the impact of dental titanium implants on LC differentiation using a novel murine model. …”

Data_Sheet_1_Impact of Sleep–Wake-Associated Neuromodulators and Repetitive Low-Frequency Stimulation on Human iPSC-Derived Neurons.docx by Remi Yokoi (6750716)

“…The number of SBFs repeatedly increased up to 5 h after 100 nM serotonin administration, inducing a 24-h rhythm cycle. …”

Boxplots for different parameter ranges. by Adam G. Fine (21763286)

“…<p>Whiskers extend to 2.5% and 97.5%-tiles. We vary: A) Number of samples taken at each timepoint, B) Number of timepoints sampled, C) Effective population size, D) Number of hidden states in the HMM. …”

Supplementary Material for: Analysis of Key Distinct Biological Characteristics of Human Placenta-Derived Mesenchymal Stromal Cells and Individual Heterogeneity Attributing to Dono... by Tai C. (10490000)

“…CP-MSCs and AM-MSCs derived from the placentae of donors 1–3 had a higher osteogenic differentiation potential than the corresponding DP-MSCs, but those derived from the placentae of donors 4 and 5 had a markedly lower osteogenic differentiation potential than DP-MSCs. …”

Supplementary Material for: Anti-inflammatory action of antidepressants: Investigating the longitudinal effect of antidepressants on white blood cell count by Sealock J.M. (14240897)

“…We created a longitudinal model to evaluate the short-term and long-term effects of these medications on WBC count. …”

DataSheet_1_Optimizing sowing patterns in winter wheat can reduce N2O emissions and improve grain yield and NUE by enhancing N uptake.docx by Xiu Zhang (1804195)

“…Higher yields accompanied by reduced N₂O emissions are essential to synergistically reduce greenhouse warming and ensure global food security. In this study, we conducted a trial using two sowing patterns (conventional drilling sowing [CD] and wide belt sowing [WB], with seedling belt widths of 2–3 and 8–10 cm, respectively) with four N rates (0, 168, 240, and 312 kg ha^-1, hereafter N0, N168, N240, and N312, respectively) during the 2019–2020 and 2020–2021 growing seasons. …”

Presentation_1_Lack of Offspring Nrf2 Does Not Exacerbate the Detrimental Metabolic Outcomes Caused by In Utero PCB126 Exposure.pdf by Brittany B. Rice (11843912)

“…At two months of age, PCB exposure resulted in a significant reduction in the average body weight of offspring born to Nrf2 Het dams (p < 0.001) that primarily arose from the decrease in average lean body mass in offspring (p < 0.001). …”

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells by Justin R. Hassler (813970)

“…Using mRNA sequencing (mRNA-Seq), we show that unconventional <i>Xbp1</i> mRNA splicing is required to increase and decrease the expression of several hundred mRNAs encoding functions that expand the protein secretory capacity for increased insulin production and protect from oxidative damage, respectively. …”

Correlation between angles representing metatarsal alignment and relevant variables when standing on the non–dominant leg. by Akiko Imura (7245170)

“…Graphs with black circle plots indicate significant correlations with the angle representing metatarsal alignment and variables after consideringeffects of the multiple testing. (a) the foot inverts as the angle 1-2-3 becomes significantly wider; (b)% duration to load medially decreases as the angle 1-2-3 becomes significantly wider; (c) the foot inversion/eversion angle does not correlate with the angle 2-3-4; (d) % duration to load medially does not correlate with the angle 2-3-4; (e) the foot inversion/eversion angle does not correlate with the angle 3-4-5; (f) % duration to load medially does not correlate with the angle 3-4-5.…”

Changes in inpatient payer-mix and hospitalizations following Medicaid expansion: Evidence from all-capture hospital discharge data by Seth Freedman (4476589)

“…</p><p>Design, setting, and participants</p><p>We compared outcomes between states that did and did not expand Medicaid using state-level all-capture discharge data from 2009–2014 for 42 states from the Healthcare Costs and Utilization Project’s FastStats database; for a subset of states we used data through 2015. …”

DataSheet_1_Year-round foraging across large spatial scales suggest that bowhead whales have the potential to adapt to climate change.pdf by Sarah M. E. Fortune (4610563)

“…We found no differences with regards to whale sex and size, but we did find evidence that subsurface foraging occurs year-round, with peak foraging occurring in fall (7.3 hrs d^-1 ± 5.70 SD; October) and reduced feeding during spring (2.7 hrs d^-1 ± 2.55 SD; May). …”

NOS network and reporters expression for cell lines grown 2i conditions. by Elsa Abranches (261932)

“…While, for both cell lines, <i>Oct4</i> and <i>Sox2</i> expression does not change significantly (p-value >0.10), both <i>VNP</i> and <i>Nanog</i> expression levels show a 2–3 fold increase (*p-value <0.03). This change is accompanied by a decrease in the expression levels of <i>Fgf5</i> and <i>Dusp6</i> when FGF/ERK signaling is abolished (**p-value <5.8×10⁻⁶). …”

Data_Sheet_1_Transplants, Open Top Chambers (OTCs) and Gradient Studies Ask Different Questions in Climate Change Effects Studies.docx by Yan Yang (33204)

“…Thus, to examine how different methods in climate change effect studies may ask different questions, we combined three climate warming approaches in a single study in the Hengduan Mountains of southwestern China. …”

Data_Sheet_1_Association Between Dairy Intake and Executive Function in Chinese Children Aged 6–12 Years.docx by Xia Zeng (2264800)

“…In the analysis of multivariate linear regression, we found that for every one unit increase in full-fat dairy intake, T-scores for Shift (β = −0.350 (95% confidence interval [CI]: (−0.660, −0.039) and Initiate (β = −0.486 (95% CI: (−0.845, −0.127) were decreased and for every one unit increase in low-fat dairy intake, T-score for Organizations of Materials (β = −0.940 (95% CI: (−1.690, −0.189) was decreased. …”

Summary of the in vitro and in vivo characterization of PCNA mutants. by Yearit Fridman (240019)

“…</p>b<p>Binding characterization of the PCNA mutants for the five target partners (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000507#pbio-1000507-g002" target="_blank">Figure 2</a>) using Y2H and SPR assays. …”

Structural model for AChE_586-599 amyloid assembly based on conformation, fibrilization and surfactant properties of the wild type and mutant peptides. by Létitia Jean (32613)

“…On the right panel, the chains are colored by residue type with hydrophobic residues (A, F, W, M and V) in green, negatively charged (E) in red, positively charged (H, R and K) in blue, and polar (S and Y) in cyan. …”

Functional Polymorphisms in the <em>TERT</em> Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers by Jonathan Beesley (89897)

“…We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the <em>TERT</em> promoter. …”