Self-renewal and differentiation of neural stem/progenitor cells. by Qingfa Chen (739620)

“…<p><b>A–J,</b> Evaluation of the population of cells that re-enter and exit the cell cycle in <i>Nestin;Epha4</i>^<i>fx/fx</i> and <i>GFAP;Epha4</i>^<i>fx/fx</i> mice between E13.5 and E15.5. …”

Table_5_Living at the Edge: Increasing Stress for Plants 2–13 Years After the Retreat of a Tropical Glacier.DOCX by Fabien Anthelme (475650)

“…To this end, we examined plant succession along a very short post-glacial chronosequence in the tropical Andes of Ecuador (2–13 years after glacial retreat). …”

Voxel-wise VBM statistics of whole brain white matter structure revealed one significant cluster with decreased white matter density when comparing CRPS patients to matched control... by Burkhard Pleger (71692)

Image_5_Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease.TIF by Amy I. Smith-Dijak (6706505)

“…One type of HSP is synaptic scaling, in which the strength of all of the synapses onto a cell increases or decreases following changes in the cell’s level of activity. …”

Data_Sheet_1_Identification and Validation of an Antivirulence Agent Targeting HlyU-Regulated Virulence in Vibrio vulnificus.docx by Saba Imdad (5206139)

“…Here, we developed an inhibitor-screening reporter platform to target HlyU, a master transcriptional regulator of virulence factors in V. vulnificus by assessing rtxA1 transcription under its control. …”

Schematic draw of a metapopulation network with human mobility. by Jorge Velázquez-Castro (4846324)

A metalloproteinase of the disintegrin and metalloproteinases and the ThromboSpondin Motifs 6 as a novel marker for colon cancer: functional experiments by Yun-Peng Wang (291612)

Assessing emotions conveyed and elicited by patient narratives and their impact on intention to participate in colorectal cancer screening: A psychophysiological investigation by Teresa Gavaruzzi (5464847)

“…Study 2 used a mixed design, with the narrative content as a within-participants factor and whether emotions were expressed by the narrative character or not as between-participants factor. …”

Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

Subjects:

Table_5_Causal effects of nonalcoholic fatty liver disease on cerebral cortical structure: a Mendelian randomization analysis.docx by Zhiliang Mai (17312719)

“…</p>Methods<p>We conducted a Mendelian randomization (MR) study using genetic predictors of alanine aminotransferase (ALT), NAFLD, and percent liver fat (PLF) and combined them with genome-wide association study (GWAS) summary statistics from the ENIGMA Consortium. …”

Loss of neuronal Pol III transcription does not affect lifespan, and gut 5S rRNA or brain <i>dMaf1</i> levels do not change during aging, with decreased Pol III subunits levels wit... by Bowen Xu (5903801)

Image5_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

“…Our search identified that miR-204-5p and miR-211-5p (miR-204/211), two broadly conserved miRNAs, share PDIA1 as a potential target. …”

Table 1_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.xlsx by Didar Murad (12220805)

“…Simulation results highlight key components affected, including thrombin, tissue plasminogen activator, plasmin, fibrin degradation products, interleukin 6 (IL-6), the IL-6 and IL-6R complex, and the terminal complement complex (C5b-9). We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”

Table 1_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.xlsx by Didar Murad (12220805)

“…Simulation results highlight key components affected, including thrombin, tissue plasminogen activator, plasmin, fibrin degradation products, interleukin 6 (IL-6), the IL-6 and IL-6R complex, and the terminal complement complex (C5b-9). We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”

Table_5_Proteomic analysis of the regulatory networks of ClpX in a model cyanobacterium Synechocystis sp. PCC 6803.xlsx by Yumeng Zhang (3115050)

“…PCC 6803 (hereafter Synechocystis). We showed that the interruption of clpX led to slower growth, decreased high light tolerance, and impaired photosynthetic cyclic electron transfer. …”

Table_5_Inflammatory cytokines and stroke and its subtypes: a genetic correlation and two-sample Mendelian randomization study.XLSX by Yu Guo (102701)

“…The inverse-variance weighted (IVW) method was adopted as the main MR method, and we performed a series of two-sample Mendelian randomizations and related sensitivity analyses.…”

Co-ordinated spatial propagation of blood plasma clotting and fibrinolytic fronts - Fig 1 by Ansar S. Zhalyalov (4233721)

“…Time course of clot growth front (A5) or clot growth and lysis fronts (B5) allows to calculate the velocities of clot growth or lysis as the average velocity of growth or lysis front propagation within the first 5 minutes after the onset of the process. …”

KO of <i>grp-1</i>, a GEF that stimulates Arf and PIP5K/PPK-1 to increase production of PIP2 substrate for the IIS cascade, provides neuroprotection. by Nazila Tehrani (665802)

“…<p>Left: a histogram showing a decrease in neurodegeneration upon KO of <i>grp-1</i> (a second independent cross gave very similar distribution, not shown) **: p<0.05; ***: p<0.01. …”

Effects of a clinical medication review focused on personal goals, quality of life, and health problems in older persons with polypharmacy: A randomised controlled trial (DREAMeR-s... by Sanne Verdoorn (6680822)

“…The main study limitations include the risk of bias due to the lack of blinding and difficulties in demonstrating which part of this complex intervention (for example, goal setting, extra attention to patients, reducing health problems, drug changes) contributed to the effects that we observed.</p><p>Conclusions</p><p>In this study, we observed that a CMR focused on personal goals improved older patients’ lives and wellbeing by increasing quality of life measured with EQ-VAS and decreasing the number of health problems with impact on daily life, although it did not significantly affect quality of life measured with the EQ-5D. …”

Inhibitory effects of FIPI or VU0155072-2 “NOPT” in mouse mammary tumors following xenotransplantation of human breast cancer cells. by Karen M. Henkels (3350273)

“…<p>(<b>A-C</b>) SCID mice were xenotransplanted with human MDA-MB-231 breast cancer cells following implantation of Alzet pumps containing 2 different PLD-small molecule inhibitors of activity: 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) or N- [2- (4- oxo- 1- phenyl- 1, 3, 8- triazaspiro[4, 5]dec- 8- yl)ethyl]- 2- naphthalenecarboxamide (VU0155072-2) [also referred to as “NOPT” [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0166553#pone.0166553.ref031" target="_blank">31</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0166553#pone.0166553.ref040" target="_blank">40</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0166553#pone.0166553.ref042" target="_blank">42</a>]]. …”