Image5_Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways.TIF by Xiu-lian Lin (13935582)

“…<p>In recent years, small intestine as a key target in the treatment of Inflammatory bowel disease caused by NSAIDs has become a hot topic. …”

Visualization of profiling output using the <i>aprof</i> package for R code, where the amount of time spent in each line of code is indicated by the blue bars. by Marco D. Visser (713100)

Safety and tolerability of high-dose ulinastatin after 2-hour intravenous infusion in adult healthy Chinese volunteers: A randomized, double-blind, placebo-controlled, ascending-do... by Qian Chen (1235499)

“…The most common drug-related adverse events included dizziness, pain at injection site, and a decrease in white blood cell count. All adverse events were of mild severity; none were serious. …”

Table_1_Impact of mandatory masking amid the COVID-19 pandemic on outdoor smoking: an interrupted time-series analysis of a 33-month unobtrusive observational study.DOCX by Yuying Sun (3820768)

State Anxiety and Nonlinear Dynamics of Heart Rate Variability in Students by Dimitriy A. Dimitriev (848310)

“…For each student, two 5-minute recordings of beat intervals (RR) were performed: one during a rest period and one just before a university examination, which was assumed to be a real-life stressor. …”

Efficient differentiation of myeloid cells in <i>Nfix</i> expressing cells. by Caitríona O’Connor (703549)

“…The mean percentage of erythroid (E), granulocyte/erythrocyte/monocyte/megakaryocyte (GEMM), granulocyte/monocyte (GM) macrophage (M) and granulocyte (G) colonies are shown from 3 independent experiments +/- SEM. A statistically significant decrease in CFU-EE colonies indicated. …”

Image_5_Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections.TIF by Huan Yang (36076)

“…CD36 expression in macrophages was found to be decreased by CNF1 in vitro and in vivo. We demonstrated that CNF1 attenuated CD36 transcription by decreasing expressions of its upstream transcription factors LXRβ and C/EBPα and their recruitment to the CD36 promotor. …”

Image 5_Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity.tif by Michael J. Clowers (15165896)

“…One of the lynchpins of chronic inflammation in KM-LUAD is signal transducer and activator of transcription 3 (STAT3).</p>Methods<p>Here, we tested the anti-tumor and early immunotherapeutic efficacy of TTI-101, a selective small-molecule inhibitor of canonical STAT3 signaling, in a K-ras^G12D mutant lung cancer mouse model (CC-LR).…”

Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma by Julia Liep (849025)

“…</p><p>Results</p><p>In functional analysis, a tumor suppressive effect of miR-141-3p and miR-145-5p by decreasing migration and invasion of RCC cells could be shown. …”

Correlation between total memory or naïve Tregs with PD1⁺ CD95⁺ cells. by Vedran Brezar (337452)

TDAG-8 and OGR-1 expression in patients with TB Lymphadenitis. by Ashley M. Whittington (16510641)

Size distribution of α-syn aggregates in endosomal vesicles in time. by Mihaela M. Apetri (2623366)

“…(ANOVA significance levels: (a)-(b): 10⁻⁴; (b)-(c):5×10⁻³; ((a)-(c):10⁻⁷). …”

HIV-specific CD4⁺ T-cell responses were amplified by IL-2 treatment and inversely correlate with VL after treatment interruption. by Vedran Brezar (337452)

Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma by Julia Liep (849025)

“…</p> <p><b>Results</b></p> <p>In functional analysis, a tumor suppressive effect of miR-141-3p and miR-145-5p by decreasing migration and invasion of RCC cells could be shown. …”

Deletion of Fibroblast Growth Factor Receptor 2 from the Peri-Wolffian Duct Stroma Leads to Ureteric Induction Abnormalities and Vesicoureteral Reflux by Kenneth A. Walker (280683)

“…P1 mutant mice also had improper ureteral bladder insertion sites and shortened intravesicular tunnel lengths that correlated with VUR. E10.5 <em>Fgfr2^ST−/−</em> mice had decreases in <em>Bmp4</em> mRNA in stromal tissues, suggesting a mechanism underlying the ureteric induction and VUR phenotypes.…”

Image5_The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning.tif by Le-le Zhang (477674)

“…</p>Methods<p>We successfully constructed a fear- formation model by foot-shock. …”

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals by Sayaka Akieda-Asai (245128)

“…Using LC/MS-based interactomics, phosphatidylinositol-4-phosphate 5-kinase (PIP5K)γ was identified as a SIRT1 binding partner and deacetylation substrate. …”

Magnetoresistance Effects Evidencing the π−d Interaction in Metallic Organic Conductors, (EDT-DSDTFVO)₂•MX₄ (M = Fe, Ga; X = Cl, Br) by Hideki Fujiwara (1512082)

“…A large negative magnetoresistance (MR) effect [−14.7% (ρ_⊥) at 4.0 K and 5 T] was observed in the FeCl₄^- salt, while a positive MR effect [+4.0% (ρ_⊥) at 4.0 K and 5 T] was observed in the GaCl₄^- salt, suggesting that there is a π−d interaction in the FeCl₄^- salt. …”

Image5_Anti-inflammatory and immunomodulatory effects of polysaccharide extracted from Wuguchong (maggot) on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice.TIF by Fangli Peng (12566343)

“…In addition, PEW treatment decreased the levels of serum IgE and histamine, the frequencies of Th1 and Th17 cells, as well as the mRNA expression levels of Th1 and Th17 cytokines and nuclear transcript factors (IFN-γ, T-bet, IL-17A, and ROR-rt). …”

DataSheet_5_Tumor-Infiltrated CD8+ T Cell 10-Gene Signature Related to Clear Cell Renal Cell Carcinoma Prognosis.csv by Jie Wang (16762)

“…It is noteworthy that SAP18 derived from CD8+ T cells negatively correlates to Atg7+ neutrophils in ccRCC, compared with papRCC, indicating a potential decreased neutrophil metabolic function in autophagy and fatty acids. …”