Image 1_Comparative analysis of gut microbiota in metabolic syndrome and obese children from Southeastern China.jpeg by Jingjing Wang (140791)

“…To investigate the differences in gut microbiota, we conducted physiological and biochemical assessments, alongside 16S rRNA sequencing, in a cohort of 32 children from Southeastern China, which included 4 normal-weight children, 5 with mild obesity, 9 with moderate obesity, 9 with severe obesity, and 5 with metabolic syndrome. …”

Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarizationactivated channel by Yu-Long Li (311230)

“…<strong>Methods and results:</strong> Using the whole-cell patch clamp technique, we found that AB neuron excitability (action potential frequency at 50 pA current stimulation) in the T1D rats was lower than that in the sham rats (0.4 ± 0.5 vs. 4.8 ± 0.6 spikes/sec, p<0.05; AB neurons were identified by DiI staining). …”

Urbanization and translocation disrupt the relationship between host density and parasite abundance by Jayna L. DeVore (2927751)

“…We studied the interaction between the cane toad (Rhinella marina), a globally invasive species native to South America, and its Amblyomma ticks. …”

TNFα promotes proliferation of human synovial MSCs while maintaining chondrogenic potential by Mikio Shioda (4033967)

“…<div><p>Synovial mesenchymal stem cells (MSCs) are a candidate cell source for cartilage and meniscus regeneration. …”

Data_Sheet_1_Characterization of regulatory genes Plhffp and Plpif1 involved in conidiation regulation in Purpureocillium lavendulum.pdf by Yu Wei (365236)

“…Among these mutants, 131 strains exhibited abnormal conidiation, and further in-depth investigations were conducted on two strains (designated as #5-197 and #5-119) that showed significantly reduced conidiation. …”

Table_1_Continuous low-dose cyclophosphamide plus prednisone in the treatment of relapsed and refractory multiple myeloma with severe complications.xlsx by Haotian Shi (1467646)

“…In addition, we found the pro-BNP/BNP level was obviously decreased while the LVEF (left ventricular ejection fraction) was increased in RRMM patients following CP treatment as compared with those before treatment. …”

Trend analysis of major cancer statistics according to sex and severity levels in Korea by Minsu Ock (3109788)

“…Among the five cancers affecting both sexes, sex-related differences in 5-year observed survival rates for lung cancer were greatest in the localized stage (men, 31.9%; women, 48.1%), regional stage (men, 20.0%; women, 31.3%), and unknown stage (men, 24.3%; women, 37.5%). …”

Supplementary Material for: Oral Immunotherapy in Japanese Children with Anaphylactic Peanut Allergy by Nagakura K. (3610526)

“…<b><i>Methods:</i></b> We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline double-blind, placebo-controlled food challenge. …”

Rapamycin-independent <i>IGF2</i> expression in <i>Tsc2</i>-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells by Blanca E. Himes (153105)

“…Using RNA-Seq, we identified (1) <i>Insulin-like Growth Factor</i> (<i>IGF2</i>) as one of the genes with the highest fold-change difference between human <i>TSC</i>2-null and <i>TSC</i>2-expressing angiomyolipoma cells from a patient with LAM, and (2) the mouse <i>IGF2</i> homolog <i>Igf2</i>, as a top-ranking gene according to fold change between <i>Tsc</i>2^-/- and <i>Tsc</i>2^+/+ mouse embryo fibroblasts (MEFs). …”

Data_Sheet_1_Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro.PDF by Dylan Nichols (6880322)

“…To address these barriers, we present a drug delivery approach for sustained release of phosphates from poly(ethylene) glycol (PEG) hydrogel nanoparticles. …”

DataSheet1_FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway.docx by Shike Yan (777488)

“…Scavenging ROS not only alleviated FGFC1-induced apoptosis but also relieved the decrease of phospho-Akt. We further confirmed that FGFC1 significantly decreased the phosphorylation of protein EGFR, phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) in H1975 cells. …”

Data_Sheet_1_Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia.docx by Santo Previti (4350607)

“…In light of this, we report here a structure-activity relationship study in which pairs of NT(8-13) analogs have been developed, based on the incorporation of a reduced Lys⁸-Lys⁹ bond. …”

The Biodiversity of the Mediterranean Sea: Estimates, Patterns, and Threats by Marta Coll (213022)

“…<div><p>The Mediterranean Sea is a marine biodiversity hot spot. Here we combined an extensive literature analysis with expert opinions to update publicly available estimates of major taxa in this marine ecosystem and to revise and update several species lists. …”

Image_1_Metabolic reprogramming through mitochondrial biogenesis drives adenosine anti-inflammatory effects: new mechanism controlling gingival fibroblast hyper-inflammatory state.... by Nathalie Paladines (16035533)

“…This is exemplified by their hypersecretion of CXCL8, enhancing leukocyte infiltration in chronic and sustained inflammatory conditions. We have previously shown adenosine to be a key metabolic nucleoside that regulates stromal inflammation, but the underlying mechanisms linking adenosine to the metabolic status of fibroblasts and to the resultant inflammatory response are unclear. …”

Image_2_Metabolic reprogramming through mitochondrial biogenesis drives adenosine anti-inflammatory effects: new mechanism controlling gingival fibroblast hyper-inflammatory state.... by Nathalie Paladines (16035533)

“…This is exemplified by their hypersecretion of CXCL8, enhancing leukocyte infiltration in chronic and sustained inflammatory conditions. We have previously shown adenosine to be a key metabolic nucleoside that regulates stromal inflammation, but the underlying mechanisms linking adenosine to the metabolic status of fibroblasts and to the resultant inflammatory response are unclear. …”

DataSheet1_Exploring the naturally acquired response to Pvs47 gametocyte antigen.docx by Gisele Tatiane Soares da Veiga (19828473)

“…Anti-Pvs47 IgM and IgG responses in symptomatic individuals decrease over time. Furthermore, we observed a negative correlation between anti-Pvs47 IgM response and gametocytemia in samples of symptomatic patients, indicating a gametocyte-specific response. …”

Effect of concurrent training on gender-specific biochemical variables and adiposity in obese adolescents by Barbara de Moura Mello Antunes (6146822)

“…<div><p>Objective The purpose of the present study was to analyze the effects of a 20-week concurrent training (20 WCT) intervention program on gender-specific body composition and metabolic variables in obese adolescents.Subjects and methods Sample was composed of twenty-five obese adolescents, aged between 12 and 15 (13.4 ± 0.96) years. …”

Role of Transition Plans on Emotional Well-Being in Young Adults with High-Functioning Autism by Imari Nicoloff (792650)

“…T-scores from the Beck Anxiety Inventory and Beck Depression Inventory, Second Edition were analyzed. The mean t-scores on the Beck Anxiety Inventory were 58.9 for participants who indicated they had left high school with a transition plan and 74.5 for those individuals who did not have a transition plan prior to leaving high school. …”

Supplementary Material for: MDM2 is essential to maintain the homeostasis of epithelial cells by targeting p53 by Wang S. (3116754)

“…A mechanistic study showed that following the decreased expression of Mdm2 in lung epithelial cells and A549 cell line, p53 was overactivated, and the expression of its downstream genes p21, Puma, and Noxa was elevated, which resulted in apoptosis. …”

Application of Multichannel Collagen Gels in Construction of Epithelial Lumen-like Engineered Tissues by Kazuya Furusawa (1569568)

“…Here, we demonstrate a methodology for construction of various epithelial lumen-like structures by using multichannel collagen gels (MCCGs). …”