Video1_Novel Biallelic Variant in the BRAT1 Gene Caused Nonprogressive Cerebellar Ataxia Syndrome.MP4 by Yiming Qi (780014)

“…Here, we reported a 10-year-old girl with severe intellectual disability, rigidity, ataxia or dyspraxia, and cerebellar atrophy on brain MRI; two BRAT1 variants in the trans configuration [c.1014A > C (p.Pro338 = ); c.706delC (p.Leu236Cysfs*5)] were detected using whole-exome sequencing. …”

Video2_Novel Biallelic Variant in the BRAT1 Gene Caused Nonprogressive Cerebellar Ataxia Syndrome.MP4 by Yiming Qi (780014)

“…Here, we reported a 10-year-old girl with severe intellectual disability, rigidity, ataxia or dyspraxia, and cerebellar atrophy on brain MRI; two BRAT1 variants in the trans configuration [c.1014A > C (p.Pro338 = ); c.706delC (p.Leu236Cysfs*5)] were detected using whole-exome sequencing. …”

Video3_Novel Biallelic Variant in the BRAT1 Gene Caused Nonprogressive Cerebellar Ataxia Syndrome.MP4 by Yiming Qi (780014)

“…Here, we reported a 10-year-old girl with severe intellectual disability, rigidity, ataxia or dyspraxia, and cerebellar atrophy on brain MRI; two BRAT1 variants in the trans configuration [c.1014A > C (p.Pro338 = ); c.706delC (p.Leu236Cysfs*5)] were detected using whole-exome sequencing. …”

Table1_Rethinking the prognosis model of differentiated thyroid carcinoma.docx by Liang He (305820)

“…More patients were classified as stage I, and the number of stage IV patients decreased significantly. The new system had a higher proportion of variance explained (PVE) (5.04%) and lower Akaike information criterion (AIC) (18,331.906) than the 8th TNM staging system (a PVE of 4.11% and AIC of 18,692.282). …”

Image_1_Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy.TIF by Karolina Garczyńska (9671570)

“…While biochemical changes related to liver function during normal pregnancy are well understood, pregnancy-associated alterations in biophysical properties of the liver remain elusive. In this study, we investigated 26 ex vivo fresh liver specimens harvested from pregnant and non-pregnant rats by diffusion-weighted imaging (DWI) and magnetic resonance elastography (MRE) in a 0.5-Tesla compact magnetic resonance imaging (MRI) scanner. …”

Data_Sheet_2_An Environmental Flow Framework for Riverine Macroinvertebrates During Dry and Wet Seasons Through Non-linear Ecological Modeling.XLSX by Qingyi Luo (9501648)

“…In this study, we aimed to develop a robust environmental flow framework that can provide scientific evidence for sustainable water resource management. …”

Effects of GaAs laser and stretching on muscle contusion in rats by Daniela Gallon Corrêa (12816187)

“…Thirty-six male rats (349±23g) were divided into six groups (n=6): control group (CG); lesion group (LG); lesion and laser group (LLG); lesion and stretching group (LSG); lesion, laser and stretching group (LLSG); and stretching group (SG). TA was wounded by a contusion apparatus. We used GaAs laser 4.5 J/cm2 dose for 32 s each, beginning 48 h after lesion, for 7 days, once a day. …”

Biocontrol of St John’s wort (<i>Hypericum perforatum</i>) provides huge ongoing benefits to New Zealand agriculture by Simon V. Fowler (3362648)

“…Biocontrol effectiveness increased linearly in our model from 1943 (when initial local defoliation occurred) to reach 99% control nationwide by 1993 (when SJW was no longer considered a significant agricultural weed). We estimate that SJW biocontrol in NZ provided a national benefit of NZ$15.5 million in 2022, with a historical benefit–cost ratio of 6254:1. …”

Data_Sheet_1_An Environmental Flow Framework for Riverine Macroinvertebrates During Dry and Wet Seasons Through Non-linear Ecological Modeling.XLSX by Qingyi Luo (9501648)

“…In this study, we aimed to develop a robust environmental flow framework that can provide scientific evidence for sustainable water resource management. …”

The Full Capacity of AICAR to Reduce Obesity-Induced Inflammation and Insulin Resistance Requires Myeloid SIRT1 by Zhenggang Yang (120148)

“…AMPK is also a molecular target of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), which has been shown to reduce insulin resistance in various animal models. …”

Table_1_Downed woody debris varies with climate and harvesting treatment in Douglas-fir forests of British Columbia, Canada.docx by Winnifred Jean Roach (11011191)

“…Across a 900-km long latitudinal gradient in British Columbia, we found that coarse woody debris (CWD, >7.5 cm diameter) in humid climates contained 700% greater carbon stocks, had 500% greater volume, and was more diverse than in arid climates. …”

Sulindac Compounds Facilitate the Cytotoxicity of β-Lapachone by Up-Regulation of NAD(P)H Quinone Oxidoreductase in Human Lung Cancer Cells by Hsiu-Ni Kung (138467)

“…In addition, β-lapachone toxicity was positively correlated with the expression and activity of NAD(P)H quinone oxidoreductase 1 (NQO1) in the tumor cells. In the second part, we found that the FDA-approved non-steroidal anti-inflammatory drug sulindac and its metabolites, sulindac sulfide and sulindac sulfone, increased NQO1 expression and activity in the lung adenocarcinoma cell lines CL1-1 and CL1-5, which have lower NQO1 levels and lower sensitivity to β-lapachone treatment than the A549 cell lines, and that inhibition of NQO1 by either dicoumarol treatment or NQO1 siRNA knockdown inhibited this sulindac-induced increase in β-lapachone cytotoxicity. …”

The Hippo pathway regulates coordinated growth of the soma and germ line. by Didem P. Sarikaya (688428)

“…<p>(A) Summary of changes in TFC, IC and GC numbers when expression of genes from various growth pathways were altered in our study and two other studies [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004962#pgen.1004962.ref006" target="_blank">6</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004962#pgen.1004962.ref049" target="_blank">49</a>]. …”

Comparison of qualitative experimental input–output relations and model predictions. by Linda Irons (9292686)

“…Model predicted absolute differences in steady state species activity when the inputs (intramural stress, wall shear stress (Wss), and AngII) are perturbed relative to baseline: orange denotes an increase and blue a decrease relative to the original steady state (white). …”

Table_1_Ebola vaccine uptake and attitudes among healthcare workers in North Kivu, Democratic Republic of the Congo, 2021.docx by Reena H. Doshi (5770502)

“…</p>Methods<p>In March 2021, we conducted a cross-sectional survey among 438 HCWs from 100 randomly selected health facilities in three health zones (Butembo, Beni, Mabalako) affected by the 10th EVD outbreak in North Kivu, DRC. …”

Effects of turbinoplasty versus outfracture and bipolar cautery on the compensatory inferior turbinate hypertrophy in septoplasty patients by Aykut Bozan (7855700)

“…Several techniques have been described to date: total or partial turbinectomy, submucosal resection (surgical or with a microdebrider), with turbinate outfracture being some of those. …”

Table_1_Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility.DOCX by Sandra Jesus (1586431)

“…Although Chit NPs and Chit polymers did not stimulate the nitric oxide (NO) production in RAW 264.7 cells, they induced a decrease in lipopolysaccharide (LPS)-induced NO production at all tested concentrations. …”

Fig 3 - by Christophe Verbist (6104075)

“…<p><b>Performance of a rat cortical pyramidal neuron model.</b> We repeated the analysis of <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1008087#pcbi.1008087.g002" target="_blank">Fig 2</a> for a model of rat neocortical layer 5 pyramidal cells. …”

Case fatality of acute coronary events is improving even among elderly patients; the FINAMI study 1995–2012 by Heli Koukkunen (4486945)

“…The incidence of MI decreased by −3.3%/year (95% CI −4.2; −2.4) in women aged 75–84 years, and by −1.2%/year (−1.9; −0.5) in women aged 85-99 years, but among men in these age-groups, only a non-significant reduction occurred. …”

Optimization produces changes in the biophysical properties of voltage-gated ion channels reducing action potential overlap load. by Biswa Sengupta (246370)

“…<p>(A) Proportional changes in the biophysical parameters of voltage-gated ion channels in five of the models after optimization. …”