Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Overexpression of ATX delays retinal vascularization and decreases vessel branching. by Hiroshi Yukiura (741223)

Decreased odor-evoked OSNs activity leads to an elevated level of TRPM5 mRNA. by Arisa Oshimoto (403221)

Decreased by Violet R. Mukaro (282939)

Decrease of NF-κB activity in tumor tissue of CCR5^−/− mice. by Ju Kyoung Song (324058)

“…<p><b>A</b>, The DNA binding activity of NF-κB was determined in the nuclear extracts of the CCR5^−/− mice and CCR5^+/+ mice tumor tissues by EMSA described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033747#s4" target="_blank">material and methods</a>. …”

Correlates of average daily step counts and average daily MVPA stratified by country in multi-variable models. by Lucy-Joy Wachira (11985899)

Subjects:

The decrease of ULK1 expression by miR-17-5p from BCG infection. by Xiangguo Duan (423329)

Cytokine dependent decrease in vSMC viability after type I NKT cell activation. by Gijs H. M. van Puijvelde (500345)

Table_5_Elevated Seawater Temperatures Decrease Microbial Diversity in the Gut of Mytilus coruscus.XLSX by Yi-Feng Li (433967)

Table 1_Effect of decreased suspended sediment content on chlorophyll-a in Dongting Lake, China.docx by Le Zhang (88249)

“…However, the effect of reduced SSC on Chl-a is poorly studied. Here, we compared and analyzed the distribution conditions of Chl-a in 6 representative years for both before the implementation of Three Gorges Dam (TGD) (BIT) and after the implementation of TGD (AIT), using the TM/OLI data and NIR-red inversion model. …”

HFA decreased expression of osteoclastic markers in alveolar bone. by Mani Alikhani (5180768)

Increasing temperature decreases oxygen concentration and decreasing oxygen content decreases neuronal excitability. by Yuguo Yu (172221)

“…Increasing temperature can dramatically decrease oxygen levels. B. Response of layer 2/3 pyramidal cells (n = 5) to the intracellular injection of a depolarizing current pulse (200 pA, 500 ms) at different temperatures (same experiments as in A). …”

Dispersion-temperature of microgels decreases at lower pHs. by Chi-Shuo Chen (234719)

“…<p>As pH is reduced from 8.0 (black) to 7.7 (blue) to 7.5 (red) to 7.3 (green), non-linear microgel dispersion-temperature changes were observed while pH decreases. …”

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta–analysis by Thomas Benichou (5047928)

“…Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta–analysis to evaluate the impact of T2DM on HRV parameters.…”

Loss of RBM-26 causes mitochondria dysfunction in PLM. by Tamjid A. Chowdhury (14149846)

Vacuolar dynamics after a rapid temperature decrease. by Noriaki Kadohama (382080)

“…<p>Vacuolar membrane labeled with FM1-43 (green) and chlorophyll fluorescence (magenta) in palisade mesophyll cells of saintpaulia leaf were observed before (A) and 10 min after (B) a rapid temperature decrease from 25°C to 5°C and kept at 5°C for 1 min. …”

12-Step Robotic Nissen Fundoplication by Benjamin A. Palleiko (10536472)

“…This video shares the authors’ twelve-step operative technique for a robotic Nissen fundoplication. …”

KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity by Mengyu Liu (2890397)

“…TMT decreased KIF5A protein expression, disrupted the interaction between KIF5A and lysosome, and impaired lysosomal axonal transport. …”

Multifunctional Resistive-Heating and Color-Changing Monofilaments Produced by a Single-Step Coaxial Melt-Spinning Process by Alexis Laforgue (2069986)

“…The mechanical properties of the monofilaments were improved by a solid-state stretching step while also decreasing their diameter. …”