Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa by Yogesh Bhootada (408443)

“…We demonstrated a pro-death role for ATF4 overexpression during autosomal dominant retinitis pigmentosa (ADRP). …”

Seed Pre-Treatment and Planting Geometry Positively Influence Herbicide Efficacy in Wheat (Triticum aestivum) by A. ULLAH (5054414)

“…In conclusion, osmoprimed seeds (1% KCl) sown in lines 22.5 cm apart gave higher wheat yields where weeds were properly controlled through application of pyroxulam applied at its recommended dose (14.08 g a.i. ha-1) and also 75% of recommended dose under Faisalabad conditions.…”

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model by Shi-Dong Ma (2746609)

“…We previously showed that EBV induces B cell lymphomas with high frequency in a cord blood-humanized mouse model in which EBV-infected human cord blood is injected intraperitoneally into NOD/LtSz-<i>scid/IL2R</i>γ^null (NSG) mice. …”

DataSheet_1_Genetically predicted levels of folate, vitamin B12, and risk of autoimmune diseases: A Mendelian randomization study.docx by Hong Yang (37298)

“…MR analyses were conducted using the inverse variance weighted (IVW) approach, and sensitivity analyses were further performed to test the robustness.</p>Results<p>We found that a higher genetically determined serum folate level per one standard deviation (SD) was associated with a decreased risk of vitiligo by the IVW method [odds ratios (OR) = 0.47; 95% confidence interval (CI): 0.32–0.69; P = 1.33 × 10^-4]. …”

DataSheet_1_UBE2S and UBE2C confer a poor prognosis to breast cancer via downregulation of Numb.docx by Yanjing Guo (720645)

Presentation_2_A new FRDA mouse model [Fxnnull:YG8s(GAA) > 800] with more than 800 GAA repeats.PPTX by Ester Kalef-Ezra (8937515)

“…In addition, increased DNA methylation of CpG U13 was identified in FXN GAA repeat region in the brain, cerebellum, and heart tissues. Furthermore, we show decreased histone H3K9 acetylation and increased H3K9 methylation of YG8JR cerebellum tissues within the FXN gene, upstream and downstream of the GAA repeat region compared to Y47JR controls.…”

Presentation_1_A new FRDA mouse model [Fxnnull:YG8s(GAA) > 800] with more than 800 GAA repeats.PPTX by Ester Kalef-Ezra (8937515)

“…In addition, increased DNA methylation of CpG U13 was identified in FXN GAA repeat region in the brain, cerebellum, and heart tissues. Furthermore, we show decreased histone H3K9 acetylation and increased H3K9 methylation of YG8JR cerebellum tissues within the FXN gene, upstream and downstream of the GAA repeat region compared to Y47JR controls.…”

DataSheet_1_Variation in intraocular pressure by sex, age, and geographic location in China: A nationwide study of 284,937 adults.docx by Xuan Liu (49954)

“…For women, it decreased from 10.5-22.0 to mmHg at age 18-24 years to 10.0-21.0 mm Hg at age ≥70 years.…”

Table 2_Revealing fitness and virulence determinants of hypervirulent Klebsiella pneumoniae during infection in Galleria mellonella using a transposon library.xlsx by Lisheng Xiao (15919517)

“…In this study, we systematically identified genes involved in host adaptation by generating a transposon mutant library and integrating a Galleria mellonella infection model with transposon sequencing (Tn-seq) technology. …”

Image_2_Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of ODZ1 Gene Expression.TIF by Carlos Velásquez (7482224)

“…In vitro methylation of the promoter decreases its transactivation activity and we found a functionally active CpG site at the 3'end of the promoter. …”

Anti-Leukemia Activity of <em>In Vitro</em>-Expanded Human Gamma Delta T Cells in a Xenogeneic Ph⁺ Leukemia Model by Gabrielle M. Siegers (123297)

“…We have developed a protocol to expand human GDTc <em>in vitro</em>, yielding highly cytotoxic Vgamma9/Vdelta2 CD27/CD45RA double negative effector memory cells. …”

Table 1_Revealing fitness and virulence determinants of hypervirulent Klebsiella pneumoniae during infection in Galleria mellonella using a transposon library.xlsx by Lisheng Xiao (15919517)

“…In this study, we systematically identified genes involved in host adaptation by generating a transposon mutant library and integrating a Galleria mellonella infection model with transposon sequencing (Tn-seq) technology. …”

Image_1_Abnormal Stability of Dynamic Functional Architecture in Amyotrophic Lateral Sclerosis: A Preliminary Resting-State fMRI Study.TIF by Jin Wei (424761)

“…The disease severity was assessed with the Revised ALS Functional Rating Scale (ALSFRS-R). We used a sliding window correlation approach to identify dynamic FC and measured the concordance of dynamic FC over time to obtain the functional stability of each voxel. …”

Image_1_Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of ODZ1 Gene Expression.TIF by Carlos Velásquez (7482224)

“…In vitro methylation of the promoter decreases its transactivation activity and we found a functionally active CpG site at the 3'end of the promoter. …”

Table_1_A health-promoting role of exclusive breastfeeding on infants through restoring delivery mode-induced gut microbiota perturbations.xlsx by Yu Liu (6938)

“…We also assessed the relationship between infant respiratory infection susceptibility and gut microbial changes associated with delivery mode and feeding pattern. …”

The Impact of Case Diagnosis Coverage and Diagnosis Delays on the Effectiveness of Antiviral Strategies in Mitigating Pandemic Influenza A/H1N1 2009 by Joel K. Kelso (238234)

“…If diagnosis occurred without delay, ARs decreased to 17%, 12.2% or 8.8% respectively. If 90% of symptomatic cases were diagnosed (with a 24 hour delay), ARs decreased to 17.8%, 11.1% and 7.6%, respectively.…”

Data Sheet 1_Campylobacter colonization and undernutrition in infants in rural eastern Ethiopia — a longitudinal community-based birth cohort study.docx by Dehao Chen (4966207)

“…</p>Methods<p>We followed a birth cohort of 106 infants in rural smallholder households in eastern Ethiopia up to 13 months of age. …”

Hepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine <i>M</i>.<i>tb</i> infection model by Rachel Harrington-Kandt (4760325)

“…Hepatic expression of iron-responsive genes was measured by qRT-PCR and bacterial burden determined in organ homogenates. We found that hepatic <i>Hamp1</i> mRNA levels decreased post-infection, and correlated with a marker of BMP/SMAD signalling pathways. …”

DataSheet_1_Understanding the taxonomic homogenization of road-influenced plant assemblages in the Qionglai mountain range: A functional and phylogenetic perspective.docx by Honglin Li (19441)

“…We used a structural equation modeling approach (SEM) to consider several surrogates of road disturbance (changes in soil physicochemical properties and the presence or absence of roads) and the causal relationship between three facets of beta diversity (taxonomic beta diversity, TBD; functional beta diversity, FBD and phylogenetic beta diversity, PBD). …”

Impact of probiotic <i>Saccharomyces boulardii</i> on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled trial by Judit Villar-García (3912757)

“…Thus, in this work, we propose a new therapeutic strategy using the probiotic yeast <i>S</i>. …”