Video1_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.MP4 by Kai Wang (21246)

“…We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD₉₀ prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.…”

Table1_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.DOCX by Kai Wang (21246)

“…We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD₉₀ prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.…”

Video3_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.MP4 by Kai Wang (21246)

“…We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD₉₀ prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.…”

Image3_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.TIF by Kai Wang (21246)

“…We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD₉₀ prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.…”

Image4_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.TIF by Kai Wang (21246)

“…We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD₉₀ prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.…”

Image2_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.TIF by Kai Wang (21246)

“…We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD₉₀ prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.…”

Table1_Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment.DOCX by Kai Wang (21246)

“…We found that chronic mavacamten treatment of R403Q ECTs: (i) shortened relaxation time, (ii) reduced APD₉₀ prolongation, (iii) upregulated ADRB2, ATP2A2, RYR2, and CACNA1C, (iv) decreased B-type natriuretic peptide (BNP) mRNA and protein expression levels, and (v) increased sarcomere length and reduced sarcomere disarray.…”

Comprehensive gene expression analyses of differentiating ES cells. by Hitomi Miyazaki (481306)

“…(<b>B</b>) Gene ontology analysis of ΔSET-impaired 152 genes. A subset of RA-responsive genes demonstrating a greater-than-2-fold decrease in the modified FPKM values in differentiating ΔSET ES cells was analyzed. …”

Differential histone diffusivity between chromatin compartments explains histone dilution kinetics during replication. by Archit Singh (17667072)

“…Empty spots arising out of histone dilution are filled with untagged histones, thereby leading to a decrease in number of tagged histones at the locus <i>R</i>*. …”

wek knock-down caused DAN loss in the absence of infection. by Deepanshu N. D. Singh (20721878)

“…<p><i>wek-RNAi</i> knock-down caused a decrease in TH + DANs PPL1 <b>(A)</b> and PPL2 <b>(B),</b> that was not rescued with the over-expression of <i>wek</i> caused by <i>B. bassiana</i> infection, suggesting that <i>wek</i> is required for DAN differentiation. …”

Burden and trend of diet-related non-communicable diseases in Australia and comparison with 34 OECD countries, 1990-2015: findings from the Global Burden of Disease Study 2015. by Melaku, Yohannes Adama

“…In 2015, the estimated number of deaths attributable to dietary risks was 29,414 deaths [95% uncertainty interval (UI) 24,697 - 34,058 or 19.7% of NCD deaths] and 443,385 DALYs (95% UI 377,680-511,388 or 9.5% of NCD DALYs) in Australia. Young (25-49 years) and middle-age (50-69 years) male adults had a higher PAF of diet-related NCD deaths and DALYs than their female counterparts. …”
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Presentation_1_CD56-negative NK cells: Frequency in peripheral blood, expansion during HIV-1 infection, functional capacity, and KIR expression.pptx by Alexander T. H. Cocker (8436300)

“…We found in 757 individuals, from a combined 28 studies and 6 datasets, that the CD56neg subset constitutes 5.67% of NK cells in healthy peripheral blood, while HIV-1 infection increases this population by a mean difference of 10.69%. …”

DataSheet_1_CD56-negative NK cells: Frequency in peripheral blood, expansion during HIV-1 infection, functional capacity, and KIR expression.pdf by Alexander T. H. Cocker (8436300)

“…We found in 757 individuals, from a combined 28 studies and 6 datasets, that the CD56neg subset constitutes 5.67% of NK cells in healthy peripheral blood, while HIV-1 infection increases this population by a mean difference of 10.69%. …”

Differences in Meiotic Recombination Rates in Childhood Acute Lymphoblastic Leukemia at an MHC Class II Hotspot Close to Disease Associated Haplotypes by Pamela Thompson (449563)

“…To determine the relationship between this observation and <i>HLA-DPB1</i> associations, we constructed high density SNP haplotypes of the 316 kb region from <i>HLA-DMB</i> to <i>COL11A2</i> in childhood ALL and controls using a UK GWAS data subset and the software PHASE. …”

Data_Sheet_1_Association of dietary total antioxidant capacity and its distribution across three meals with all-cause, cancer, and non-cancer mortality among cancer survivors: the... by Peng Wang (34436)

“…We included 5,009 patients with cancer from the National Health and Nutrition Examination Survey conducted between 1999 and 2018. …”

Airborne health-related substances and their association with the SRB. by Yanan Long (11784717)

“…Each plot shows bar plots of regression coefficients and 95% confidence intervals (error bar) of the second to the seventh septiles, with the first septile chosen as the reference level. We rank the 12 models by the statistically significant factor’s association strength with at least one statistically significant coefficient by decreasing ΔIC; septiles whose coefficients are not significantly different from 0 at the 95% confidence level have been plotted with a reduced alpha level. …”

Eyes shut homolog is important for the maintenance of photoreceptor morphology and visual function in zebrafish by Muriël Messchaert (5565926)

“…To study the function of EYS, we generated a stable <i>eys</i>^{<i>rmc101/rmc101</i>} mutant zebrafish model using CRISPR/Cas9 technology. …”

Differences in Meiotic Recombination Rates in Childhood Acute Lymphoblastic Leukemia at an MHC Class II Hotspot Close to Disease Associated Haplotypes by Pamela Thompson (449563)

“…To determine the relationship between this observation and <i>HLA-DPB1</i> associations, we constructed high density SNP haplotypes of the 316 kb region from <i>HLA-DMB</i> to <i>COL11A2</i> in childhood ALL and controls using a UK GWAS data subset and the software PHASE. …”

Quantification of c-Fos IR-neurons in two groups of zebra finches. by Nina Keary (320316)

“…Equal numbers of activated neurons are found in the lateral TO and the nBOR, whereas a decreased density can be seen in the ventral TO and PrV.…”

CGSs and investigation of PC1. by Ian Smith (20961)

“…Level 5 data were used. The shRNA CGS has a notably larger PC1. …”