Video_3_Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation.avi by Scott McComb (234597)

“…Attenuated signaling in hinge-truncated EGFR-sdCAR constructs increased selectivity for antigen-dense EGFR-overexpressing cells over an EGFR-low tumor cell line or healthy donor derived EGFR-positive fibroblasts. We also provide evidence that epitope location is critical for determining hinge-domain requirement for CARs, as hinge truncation similarly decreased antigenic sensitivity of a membrane-proximal epitope targeting HER2-CAR but not a membrane-distal EGFRvIII-specific CAR. …”

EphA3 Expressed in the Chicken Tectum Stimulates Nasal Retinal Ganglion Cell Axon Growth and Is Required for Retinotectal Topographic Map Formation by Ana Laura Ortalli (159899)

“…</p> <h3>Conclusions</h3><p>We demonstrated <em>in vitro</em> and <em>in vivo</em> that EphA3 ectodomain (which is expressed in a decreasing rostro-caudal gradient in the tectum) is necessary for topographic mapping by stimulating the nasal axon growth toward the caudal tectum and inhibiting their branching in the rostral tectum. …”

Presentation_1_Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation.pdf by Scott McComb (234597)

“…Attenuated signaling in hinge-truncated EGFR-sdCAR constructs increased selectivity for antigen-dense EGFR-overexpressing cells over an EGFR-low tumor cell line or healthy donor derived EGFR-positive fibroblasts. We also provide evidence that epitope location is critical for determining hinge-domain requirement for CARs, as hinge truncation similarly decreased antigenic sensitivity of a membrane-proximal epitope targeting HER2-CAR but not a membrane-distal EGFRvIII-specific CAR. …”

Video_7_Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation.avi by Scott McComb (234597)

“…Attenuated signaling in hinge-truncated EGFR-sdCAR constructs increased selectivity for antigen-dense EGFR-overexpressing cells over an EGFR-low tumor cell line or healthy donor derived EGFR-positive fibroblasts. We also provide evidence that epitope location is critical for determining hinge-domain requirement for CARs, as hinge truncation similarly decreased antigenic sensitivity of a membrane-proximal epitope targeting HER2-CAR but not a membrane-distal EGFRvIII-specific CAR. …”

Video_4_Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation.avi by Scott McComb (234597)

“…Attenuated signaling in hinge-truncated EGFR-sdCAR constructs increased selectivity for antigen-dense EGFR-overexpressing cells over an EGFR-low tumor cell line or healthy donor derived EGFR-positive fibroblasts. We also provide evidence that epitope location is critical for determining hinge-domain requirement for CARs, as hinge truncation similarly decreased antigenic sensitivity of a membrane-proximal epitope targeting HER2-CAR but not a membrane-distal EGFRvIII-specific CAR. …”

Video_6_Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation.avi by Scott McComb (234597)

“…Attenuated signaling in hinge-truncated EGFR-sdCAR constructs increased selectivity for antigen-dense EGFR-overexpressing cells over an EGFR-low tumor cell line or healthy donor derived EGFR-positive fibroblasts. We also provide evidence that epitope location is critical for determining hinge-domain requirement for CARs, as hinge truncation similarly decreased antigenic sensitivity of a membrane-proximal epitope targeting HER2-CAR but not a membrane-distal EGFRvIII-specific CAR. …”

Image_1_Improved Thyroid Hypoechogenicity Following Bariatric-Induced Weight Loss in Euthyroid Adults With Severe Obesity—a Pilot Study.tiff by Ioannis Kyrou (5682863)

“…</p><p>Results: Ten Caucasian, euthyroid patients (women/men: 8/2; age: 48.6 ± 3.1 years; BMI: 51.4 ± 1.8 kg/m²) successfully completed this study with significantly decreased body weight (>5% weight loss), waist circumference and serum leptin levels post-surgery (mean post-surgery follow-up duration: 16.5 ± 2.5 months). …”

Table_1_Acute Effects of Cinnamon Spice on Post-prandial Glucose and Insulin in Normal Weight and Overweight/Obese Subjects: A Pilot Study.DOCX by Jing Wang (6206297)

“…In normal weight participants, we observed a decrease of post-prandial glucagon response (niAUC_0−180min and glucagon levels at 60–120 min) and C-peptide response (30 min) comparing breakfast with to without cinnamon. …”

Data_Sheet_1_The impact of teacher feedback on students’ decisions to stay on or change course after math failure in a Confucian cultural context.docx by Bih-Jen Fwu (13884139)

“…Students receiving such feedback tended to quit and change course, creating a potential decrease in the pool of students pursuing math related fields. …”

DataSheet1_Communication Apprehension and Eye Contact Anxiety in Video Conferences Involving Teleoperated Robot Avatars: A Subjective Evaluation Study.docx by Faisal Mehmood (1863337)

“…We propose a robotic telecommunication system in which a user has two options to produce utterance for own responses in online interaction with interviewer i.e., either by a robot avatar that faces the interviewer, or by self. …”

Table1_Efficacy of Xinbao pill on chronic heart failure: Study protocol of a multicenter, randomized, double-blind, placebo-controlled trial.XLSX by Yuanping Wang (714749)

“…</p><p>Methods and analysis: We will recruit 284 patients with a clinical diagnosis of “heart-kidney yang deficiency syndrome” CHF receiving treatment in six hospitals in China. …”

Table_1_Effectiveness of sigmoidoscopy or colonoscopy screening on colorectal cancer incidence and mortality: a systematic review and meta-analysis of randomized controlled trial.d... by Chunyang Han (3958958)

“…Objectives<p>We conducted a comprehensive analysis to compare colonoscopy and sigmoidoscopy with standard care or fecal immunochemistry regarding colorectal cancer incidence and mortality risk.…”

Off-hours presentation is associated with short-term mortality but not with long-term mortality in patients with ST-segment elevation myocardial infarction: A meta-analysis by Bingjian Wang (452924)

“…<div><p>Background</p><p>The association between off-hours presentation and mortality in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We performed a meta-analysis to assess the impact of off-hours presentation on short- and long-term mortality among STEMI patients.…”

Overexpression of c-Myc in ΔS6 livers does not prevent overgrowth or tumor development. by Sarah A. Comerford (3854917)

“…<p>(A) Graph of %L/BWs of WT, ΔS6, Alb-c-Myc and ΔS6:c-Myc mice at ≥ 6 months of age showing that livers of ΔS6, Alb-c-Myc and ΔS6:c-Myc mice are all predisposed to overgrow as they age. …”

File S1 - Endothelin-1 Promotes Survival and Chemoresistance in Chronic Lymphocytic Leukemia B Cells through ET_A Receptor by Rossana Maffei (501733)

“…The blockade of ET_AR by BQ-123 affects EC-mediated survival advantage at 72 h and 96 h. …”

DataSheet_1_Therapeutic Response and Possible Biomarkers in Acute Attacks of Neuromyelitis Optica Spectrum Disorders: A Prospective Observational Study.doc by Jingqi Wang (748537)

“…The treatment comprised intravenous methylprednisolone pulse therapy alone (IVMP, 71%), IVMP combined with apheresis (8%), IVMP combined with intravenous immunoglobulin (18%) and other therapies (3%). EDSS scores decreased significantly from a medium of 4 (interquartile range 3.0–5.5) at attack to 3.5 (3.0–4.5) at discharge, 3.5 (2.0–4.0) at the 1-month visit and 3.0 (2.0–4.0) at the 3-month visit (p<0.01 in all comparisons). …”

DataSheet1_Efficacy of moxibustion in diarrhea-predominant irritable bowel syndrome model rats: a systematic review and meta-analysis.PDF by Xiang Rao (17640756)

“…The meta-analysis results demonstrated that moxibustion enhanced the threshold capacity of the abdominal withdrawal reflex (AWR) [standardized mean difference (SMD) = 1.84; 95% confidence interval (CI): 1.09, 2.60; p < 0.00001], ameliorated the rate of loose stool (SMD = −4.03; 95% CI: –5.76, −2.30; p < 0.00001), and decreased the colon 5-hydroxytryptamine (SMD = −3.67; 95% CI: –5.33, −2.01; p < 0.00001), serum interleukin-1β (SMD = −3.24, 95% CI: –4.06, −2.41; p < 0.00001), serum tumor necrosis factor-α (SMD = −2.35, 95% CI: –4.12, −0.58; p < 0.00001), and serum substance P (SMD = −5.14, 95% CI: –8.45, −1.83; p = 0.002) concentrations. …”

Data_Sheet_1_A Self-Supervised Deep Learning Reconstruction for Shortening the Breathhold and Acquisition Window in Cardiac Magnetic Resonance Fingerprinting.DOCX by Jesse I. Hamilton (12910793)

“…DIP-MRF was evaluated in simulations and at 1.5 T in a standardized phantom, 18 healthy subjects, and 10 patients with suspected cardiomyopathy. …”

Impact of selective immune-cell depletion on growth of <i>Mycobacterium tuberculosis</i> (Mtb) in a whole-blood bactericidal activity (WBA) assay by Gail B. Cross (683961)

“…<div><p>We investigated the contribution of host immune cells to bacterial killing in a whole-blood bactericidal activity (WBA) assay, an ex vivo model used to test efficacy of drugs against <i>mycobacterium tuberculosis</i> (Mtb). …”

Data_Sheet_1_Transhumant Sheep Grazing Enhances Ecosystem Multifunctionality in Productive Mountain Grasslands: A Case Study in the Cantabrian Mountains.PDF by José Manuel Fernández-Guisuraga (12403243)

“…<p>Understanding the effects of traditional livestock grazing abandonment on the ability of mountain grasslands to sustain multiple ecosystem functions (ecosystem multifunctionality; EMF) is crucial for implementing policies that promote grasslands conservation and the delivery of multiple ecosystem services. In this study, we evaluated the effect of short- and long-term transhumant sheep abandonment on EMF through a grazing exclusion experiment in a grassland of the Cantabrian Mountains range (NW Spain), where transhumant sheep flocks graze in summer. …”