AST1306, A Novel Irreversible Inhibitor of the Epidermal Growth Factor Receptor 1 and 2, Exhibits Antitumor Activity Both In Vitro and In Vivo by Hua Xie (49932)

“…Recent studies have provided compelling evidence that irreversible ErbB inhibitors have the potential to override this resistance. Here, we found that AST1306, a novel anilino-quinazoline compound, inhibited the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. …”

Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein’s Beneficial Roles on Lipid Metabolism by Shibin Ding (288560)

“…<div><p>Both bisphenol A (BPA, an endocrine disrupting chemicals) and genistein (a phytoestrogen mainly derived from leguminosae) are able to bind to estrogen receptors, but they are considered to have different effects on metabolic syndrome, surprisingly. …”

DataSheet_1_Effects on the food-web structure and bioaccumulation patterns of organic contaminants in a climate-altered Bothnian Sea mesocosms.docx by Åsa M. M. Berglund (7516433)

“…We performed a mesocosms-study, focusing on aquatic food webs with fish as top predator. …”

Image6_c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease.TIF by Tamara Marín (12259079)

“…<p>Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. …”

A 3D Analysis of Flight Behavior of <i>Anopheles gambiae sensu stricto</i> Malaria Mosquitoes in Response to Human Odor and Heat by Jeroen Spitzen (127683)

“…Odor alone resulted in decreased flight speed when mosquitoes arrived within 30 cm of the source whereas mosquitoes exposed to odor+heat maintained a high flight speed while flying in the odor plume, until they arrived within 15 cm of the source. …”

Table_2_Case Report: Response to ALK-TKIs in a metastatic lung cancer patient with morphological heterogeneity and consistent molecular features.xlsx by Yu Yang (83671)

“…Additionally, somatic mutations can potentially serve as a marker of clonal relationships. We report a rare case of ASC lung cancer, in which metastases were identified as ADC, while the primary was initially diagnosed as SQCC based on a fibrobronchoscope brush biopsy. …”

Supplementary file 1_Clinical characteristics and mortality risk factors among hospitalized infants and children with pertussis in China: a retrospective study.docx by Shuhan Zheng (18614305)

“…Background<p>The resurgence of pertussis has emerged as a significant global public health threat. Severe pertussis primarily affects infants and children and is often associated with serious complications or death.…”

Image4_c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease.TIF by Tamara Marín (12259079)

“…<p>Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. …”

Differential Responses of Emergent Intertidal Coral Reef Fauna to a Large-Scale El-Niño Southern Oscillation Event: Sponge and Coral Resilience by Francisco Kelmo (417264)

“…Given the environmental variability intertidal reefs experience, such reefs may potentially be more resilient to climatic events and provide important insights into the adaptation of reef fauna to future ocean warming. Here we report the results of a 17-year (1995–2011) biodiversity survey of four emergent coral reef ecosystems in Bahia, Brazil, to assess the impact of a major El Niño event on the reef fauna, and determine any subsequent recovery. …”

DataSheet_1_Prognostic value of pan-immune-inflammation value in colorectal cancer patients: A systematic review and meta-analysis.docx by Xiao-Chuan Yang (14292227)

“…In addition, early PIV increase after treatment initiation was significantly associated with decreased overall survival (HR=1.79; 95%CI: 1.13-2.93; P=0.01; I^{2 =} 26%), and a trend toward poor progression-free survival (HR=2.00; 95%CI: 0.90-4.41; P=0.09; I^{2 =} 70%).…”

Image_1_Association Between Hormone Replacement Therapy and Development of Endometrial Cancer: Results From a Prospective US Cohort Study.TIF by Ying Liang (13730)

“…<p>Although hormone replacement therapy (HRT) use is associated with elevated endometrial cancer(EC) risk, little evidence assesses potential effect-modifiers on HRT-related EC in a long-term follow-up. In this large-scale longitudinal cohort study, we tried to evaluate the association between different HRT types/methods use and risk of EC, and reveal this risk within different body mass index (BMI) groups. …”

Versican G3 Domain Modulates Breast Cancer Cell Apoptosis: A Mechanism for Breast Cancer Cell Response to Chemotherapy and EGFR Therapy by William Weidong Du (198614)

“…Possessing anti-apoptotic and drug resistant properties, overexpression of these molecules is accompanied by selective sensitization to the process of apoptosis. In this study, we exogenously expressed a versican G3 construct in breast cancer cell lines and analyzed the effects of G3 on cell viability in fetal bovine serum free conditioned media and evaluated the effects of apoptotic agent C2-ceramide, and chemotherapeutic agents including Docetaxel, Doxorubicin, and Epirubicin. …”

Image2_c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease.TIF by Tamara Marín (12259079)

“…<p>Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder caused by the deficiency in acid sphingomyelinase (ASM) activity. …”

A Large-Scale Complex Haploinsufficiency-Based Genetic Interaction Screen in <em>Candida albicans</em>: Analysis of the RAM Network during Morphogenesis by Nike Bharucha (222826)

“…Taken together, our observations indicate that CHI–based screening is a useful approach to genetic interaction analysis in <em>C. albicans</em> and support a model in which these two pathways regulate a common set of genes at different stages of filamentation.…”

Facile Room-Temperature Synthesis of Cerium Carbonate and Cerium Oxide Nano- and Microparticles Using 1,1′-Carbonyldiimidazole and Imidazole in a Nonaqueous Solvent by Seung Woo Choi (6906134)

“…However, the precise control of the temperature is often difficult, especially in large-scale reactions. Herein, we propose a homogeneous precipitation method that uses 1,1′-carbonyldiimidazole (CDI) and imidazole in acetone without heating. …”

Table_1_Cerebral Microbleeds and Structural White Matter Integrity in Patients With Traumatic Brain Injury—A Diffusion Tensor Imaging Study.DOCX by Juho Dahl (12693071)

“…Cerebral microbleeds (CMBs) are a common finding on head imaging in TBI and are often considered a visible sign of DAI, although they represent diffuse vascular injury. …”

DataSheet_1_The postoperative analgesic efficacy of different regional anesthesia techniques in breast cancer surgery: A network meta-analysis.docx by Ran An (456243)

Image 1_Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.jpeg by Xingyao Chen (6750872)

“…In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.…”

Image_2_Total muscle-to-fat ratio influences urinary incontinence in United States adult women: a population-based study.tif by Dongmei Hong (18112637)

“…The results from the restricted cubic spline chart indicated a decreasing risk of UI in women as tMFR increased. …”

Table 1_Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.docx by Xingyao Chen (6750872)

“…In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.…”