Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality by Johannes Raffler (793347)

“…In contrast, for the <i>SLC5A11</i> locus, we found increased levels of <i>myo</i>-inositol in urine whereas mGWAS in blood reported decreased levels for the same genetic variant. …”

Twenty-two identified and replicated loci and their overlap with associations to metabolic traits and clinical phenotypes. by Johannes Raffler (793347)

“…<p>^a SNP with the strongest association to targeted metabolic traits (“lead SNP”)</p><p>^b SNP with the strongest association to non-targeted metabolic traits</p><p>^c manually added to the list of most plausible candidate genes derived by evidence-based selection</p><p>^d additional candidates match to other non-targeted traits that also associate with the lead SNP</p><p>^e results from GWAS (<i>P</i> < 5.0×10⁻⁸)</p><p>^f mutations determined in clinical studies</p><p>For each locus, we selected all variants that displayed genome-wide significant association signals to metabolic traits in the SHIP-0 cohort. …”

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity - Fig 3 by Qin Huang (49441)

Subjects:

SDG decreases iron-induced MMP gene expression in H9c2 cells. by Stephanie Puukila (568109)

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity - Fig 2 by Qin Huang (49441)

Subjects:

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity - Fig 1 by Qin Huang (49441)

Subjects:

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity - Fig 4 by Qin Huang (49441)

Subjects:

Comparison of the Th2 cytokine expression level after treatment with KA/E2 in WT and TLR2 KO mice. by Mi-Kyung Park (56053)

<i>Med23</i> deletion causes decreased H3K9me2 occupancy among the promoter of <i>Ccl5</i> and <i>Cxcl10</i>. by Zhichao Wang (3570413)

The expression of proteins involved in iron transport in SK-Mel-5 cells indicates a decrease in iron stores. by Sarah Straud (245572)

“…Relative to HeLa cells, SK-Mel-5 have decreased expression of transferrin receptor and ferritin and a large increase in expression of the iron efflux protein ferroportin. …”

Reproductive transition paralleled a significant decrease in LDH5 and LDH1 expressions in nonTg hippocampus. by Fan Ding (302565)

“…<p>A. NonTg hippocampus demonstrated a an age-related decrease in LDH5 expression from 6 to 15 months of age, which was significant between 6 and 9, 9 and 12 months of age. …”

Table_5_Decreased Functional Connectivities of Low-Degree Level Rich Club Organization and Caudate in Post-stroke Cognitive Impairment Based on Resting-State fMRI and Radiomics Fea... by Guofu Miao (11271528)

“…Rich club organization, a highly interconnected network brain core region, is closely related to cognition. …”

In we present the number of modules determined by DMSP on various values of connectivity density by Ioannis A Maraziotis (86282)

“…When we apply stricter criteria (as in red dotted line) there is a slight decrease in the number of the modules but at the same time the connectivity density values are better. …”

RNAseq analysis and MSD ELISA of proinflammatory cytokines in WT and AD mice. by David J. Braun (7107692)

Chemokines, with the exception of CXCL1 and MCP-1, decrease acutely following 5 Gy IR. by Jordan A. Gunning (18143970)

CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival by Carlos A. Mier-Aguilar (3605360)

“…Using a gene-targeted mouse in which the CD5-CK2BD is selectively ablated (CD5-ΔCK2BD), we determined that loss of function of CD5-CK2 signaling in a MHC-II selecting TCR transgenic (OT-II) mouse resulted in decrease in double positive (DP) thymocytes, which correlated with enhanced apoptosis. …”

Defects in the conduction of somatosensory evoked potentials of median and tibial nerves in a healthy child and in H-ABC patient. by Jose R. Eguibar (8563227)

Genes encoding proteins involved in other metabolic processes differentially expressed in liver of <i>Fmo5</i>^<i>-/-</i> mice compared with WT mice. by Ian R. Phillips (5074121)

Genes encoding proteins involved in amino acid metabolism differentially expressed in liver of <i>Fmo5</i>^<i>-/-</i> mice compared with WT mice. by Ian R. Phillips (5074121)

Knockdown of AR expression decreases the efficiency of KSHV infection in endothelial cells. by Xing Wang (154377)

“…(g, h) Knockdown of AR and EphA2 expression decreases nuclear LANA expression in SLK cells, as determined by an immunofluorescence assay and quantitative analysis by Image J software. …”