Monodispersed Sirolimus-Loaded PLGA Microspheres with a Controlled Degree of Drug–Polymer Phase Separation for Drug-Coated Implantable Medical Devices and Subcutaneous Injection by Zilin Zhang (4370773)

“…By increasing the drug loading from 33 to 50 wt %, the particle morphology evolved from homogeneous microspheres, in which the drug and polymer were perfectly mixed, to patchy particles, with amorphous drug patches embedded within a polymer matrix to anisotropic patchy Janus particles. …”

Monodispersed Sirolimus-Loaded PLGA Microspheres with a Controlled Degree of Drug–Polymer Phase Separation for Drug-Coated Implantable Medical Devices and Subcutaneous Injection by Zilin Zhang (4370773)

“…By increasing the drug loading from 33 to 50 wt %, the particle morphology evolved from homogeneous microspheres, in which the drug and polymer were perfectly mixed, to patchy particles, with amorphous drug patches embedded within a polymer matrix to anisotropic patchy Janus particles. …”

Rescue the Failed Half-ZFN by a Sensitive Mammalian Cell-Based Luciferase Reporter System by Weifeng Zhang (134361)

“…Lastly, site-specific genome editing by hPGRN ZFNs generated by this system was confirmed by sequencing, and the PGRN knock-out cell line showed significantly decreased cell growth compared with the control. Our system will provide a valuable tool for further optimizing the nucleases with regard to specificity and cytotoxicity.…”

Table_2_Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.XLSX by Jan Vollert (5099921)

“…Background<p>Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. …”

Table_1_Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.xlsx by Jan Vollert (5099921)

“…Background<p>Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. …”

CsrA modulates the expression of a thiamine pyrophosphate (TPP) riboswitch element. by Tobias Sahr (3756775)

“…Each value represents the mean +/- SD of three independent experiments. BlaM activity is significantly decreased in the mutant at the different conditions indicating a positive effect of CsrA on the <i>thi</i>-operon expression in <i>L</i>. …”

Data_Sheet_1_Research protocol for bridging research, accurate information and dialogue (BRAID)—clinical trials: a mixed-methods study of a community-based intervention to improve... by Damara N. Gutnick (19676227)

“…This lack of trust, particularly within underserved communities, contributes to decreased participation in clinical trials and a lack of representation in the data. …”

Electrostatic Effect of Functional Surfaces on the Activity of Adsorbed Enzymes: Simulations and Experiments by He Zheng (1439401)

Cell Type Specific Alterations in Interchromosomal Networks across the Cell Cycle by Andrew J. Fritz (638393)

“…It was also strikingly altered across the cell cycle in MCF10A, but only slightly in WI38. We conclude that CT undergo multiple and preferred interactions with other CT in the nucleus and form preferred -albeit probabilistic- interchromosomal networks. …”

Spinocerebellar ataxia type 11-associated alleles of <i>Ttbk2</i> dominantly interfere with ciliogenesis and cilium stability by Emily Bowie (543704)

“…SCA11 is caused by mutations in the gene encoding the Serine/Threonine kinase Tau tubulin kinase 2 (TTBK2) that result in premature truncations of the protein. We previously showed that TTBK2 is a key regulator of the assembly of primary cilia <i>in vivo</i>. …”

Proportion of parental line (A receptor and R pollinator) seeds improving rice hybrid production by Adriano Stephan Nascente (4647931)

“…Treatments included six proportions of seeds of the INTA Puita (0.75, 1.5, 3.0, 6.0, 12.0, and 24.00%) mixture with seeds of line 464 A (99.25, 98.50, 97.00, 94.00, 88.00, and 76%, respectively). …”

Data_Sheet_1_Elimination of hepatitis C in a hospital characterized by infectious diseases.PDF by Ying Han (137520)

“…The HCV antibody positivity rate and the proportion of positive patients showed an upward trend along with age in the five groups between 10–59 years. In the contrary, a decreasing trend was observed in the three groups above 60 years. …”

Frequency compensation in the feedback scheme of Fig 4a for a stepwise <i>k</i>₂ change (1.0 → 10.0) at background <i>k</i>₁₀ = 0.0. by Melissa Nygård (15374507)

Efficacy of Rifampin Plus Clofazimine in a Murine Model of <i>Mycobacterium ulcerans</i> Disease by Paul J. Converse (227430)

“…Footpad swelling declined comparably with all of the combination regimens, as did the levels of detectable mycolactone A/B. In mice treated for only 6 weeks and followed up for 24 weeks, there were no relapses in RIF+STR treated mice, one (5%) relapse in RIF+CFZ-treated mice, but >50% in RIF+CLR treated mice. …”

Macrophage movement with and without apoptosis. by Safia A. Essien (20108379)

The expression of nAChR subunits in breast cancer cells. by Masanori A. Murayama (5774585)

Evaluation of the Association between the AC3 Genetic Polymorphisms and Obesity in a Chinese Han Population by Hairu Wang (238131)

“…</p><h3>Methodology/Principal Findings</h3><p>In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. …”

Table 1_Survival assessment in extremely preterm neonates in a middle-income setting.docx by Maria J. Rodriguez-Sibaja (17456689)

“…This study aimed to describe the hospital discharge survival of extremely preterm infants born in a middle-income setting. As a secondary objective, we assessed the neonatal morbidity associated with this group.…”

Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens by Zahra Akbarian-Rad (8356659)

“…We performed a systematic review and meta-analysis study to evaluate the national prevalence and identification of the etiological pathogens of neonatal sepsis in Iran.…”

Magnesium oxide use and reduced risk of dementia: a retrospective, nationwide cohort study in Taiwan by Nian-Sheng Tzeng (427571)

“…</p> <p><b>Methods:</b> We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged ≥50 years with no history of MgO usage. …”