Exploration of 2‑((Pyridin-4-ylmethyl)­amino)­nicotinamide Derivatives as Potent Reversal Agents against P‑Glycoprotein-Mediated Multidrug Resistance by Qianqian Qiu (3859564)

“…In-depth studies demonstrated <b>9n</b> has high potency (EC₅₀ = 119.6 ± 6.9 nM), low cytotoxicity, and long duration (>24 h) in reversing adriamycin (ADM) resistance in K562/A02 cells. …”

Motion of a Droplet on an Anisotropic Microgrooved Surface by Manish Kumar (50435)

“…The rectangular microgrooves are manufactured on silicon wafers using standard photolithography techniques. We tilt the surface gradually using a rotating stage mechanism until the incipience of the sliding. …”

Motion of a Droplet on an Anisotropic Microgrooved Surface by Manish Kumar (50435)

“…The rectangular microgrooves are manufactured on silicon wafers using standard photolithography techniques. We tilt the surface gradually using a rotating stage mechanism until the incipience of the sliding. …”

Motion of a Droplet on an Anisotropic Microgrooved Surface by Manish Kumar (50435)

“…The rectangular microgrooves are manufactured on silicon wafers using standard photolithography techniques. We tilt the surface gradually using a rotating stage mechanism until the incipience of the sliding. …”

Transcript-Level In Silico Analysis of Alzheimer’s Disease-Related Gene Biomarkers and Their Evaluation with Bioactive Flavonoids to Explore Therapeutic Interactions by Muhammad Bilal Azmi (14519913)

“…We systematically screened transcript-level exonic rare SNPs from these genes with a minor allele frequency of 1% in 1KGD (1000 Genomes Project Database) and gnomAD (Genome Aggregation Database). …”

Photomicrographs of DG from control gerbils and during and after infection with <i>Giardia</i>. by Angélica González Maciel (18946369)

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells by V Bhattacharjee (681247)

“…A sublethal dose (50 nM) of the drug was used to model situations of limiting drug availability to PCa tumors in vivo. …”

Data_Sheet_1_The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model.PDF by Kelsey Hanson (5147819)

“…While there were no changes to tyrosinated tubulin or MAP1B, acetylated tubulin was significantly (p < 0.05) decreased by 40% at 6 h post-treatment. To determine whether increasing microtubule acetylation prior to kainic acid exposure could prevent axon fragmentation, we investigated the effect of reducing microtubule deacetylation with the HDAC6 inhibitor, trichostatin A. …”

Rb and p53 Liver Functions Are Essential for Xenobiotic Metabolism and Tumor Suppression by Sathidpak Nantasanti (3181224)

“…Protoporphyrin accumulation causes bile injury and ductular reaction. We show that loss of Rb and p53 resulted in reduced Cyp3a expression decreased accumulation of protoporphyrin and consequently less ductular reaction in livers of mice fed with DDC for 3 weeks. …”

image_1_Impaired Cerebral Autoregulation After Subarachnoid Hemorrhage: A Quantitative Assessment Using a Mouse Model.pdf by Masayo Koide (10941294)

“…Importantly, SAH animals also exhibited a marked decrease in CBF throughout the entire range of BP. …”

Effects of fin fold mesenchyme ablation on fin development in zebrafish by Robert L. Lalonde (4840260)

“…Actinodin proteins are crucial structural component of the actinotrichia. Additionally, we show a decrease in <i>hoxa13a</i>, <i>hoxd13a</i>, <i>fgf10a</i> and altered <i>shha</i>, and <i>ptch2</i> expression during larval fin development. …”

A Human Multi-Epitope Recombinant Vaccinia Virus as a Universal T Cell Vaccine Candidate against Influenza Virus by Alan G. Goodman (202321)

“…Upon challenge with influenza virus, the vaccinated mice exhibited decreased viral load in the lungs and a delay in mortality. …”

Supplementary Material for: Neovascular Maculopathy after laser 2RT in a Young Myopic Patient: A Case Report by figshare admin karger (2628495)

“…In this case, we have described a case of neovascular maculopathy occurring shortly after 2RT in a young myopic patient. …”

A single-cell survey of Drosophila blood by Sudhir Tattikota (3576881)

“…Using Monocle-3 based pseudotemporal ordering of cells, we propose that a decrease in the expression of cell cycle genes such as <i>Polo</i> as a potential mechanism of transdifferentiation <b>[BOX 2]</b>. …”

Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model by Lucie Šedová (641578)

“…Previous studies indicate the presence of significant genetic determinants of several features of metabolic syndrome on rat chromosome 16 (RNO16) and the syntenic regions of human genome. We derived the SHR.BN16 congenic strain by introgression of a limited RNO16 region from the Brown Norway congenic strain (BN-<i>Lx</i>) into the genomic background of the spontaneously hypertensive rat (SHR) strain. …”

High-performance thin-layer chromatogram of mouse brain ganglioside distribution in control (Ctl 1, Ctl 2) and experimental (VCS, #8566, #8568) brain tissue. by Jay S. Schneider (671374)

“…Note the increase in GM1 in VCS animals and decreased GD1a, GT1a, GT1b, and GQ1b, in striatal (CD) and hippocampus (HP) samples.…”

Identification of raw as a regulator of glial development by Diana Luong (5309618)

“…The reduced number of glia along peripheral nerves occurs as a result of decreased glial proliferation. As Raw has been shown to negatively regulate Jun N-terminal kinase (JNK) signaling in other developmental contexts, we examined the expression of a JNK reporter and the downstream JNK target, <i>matrix metalloproteinase 1</i> (<i>mmp1</i>), and found that <i>raw</i> knockdown results in increased reporter activity and Mmp1 levels. …”

Polysome-associated cellular mRNAs are longer and more AU-rich. by William J. Neidermyer Jr. (6866672)

“…<p>(A) Analysis of cellular mRNAs with high cytoplasmic abundance (purple) or low cytoplasmic abundance (orange) as compared to mRNAs with cytoplasmic abundance within 2 standard deviations of the mean abundance (gray) in uninfected cells. …”

A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rhabdovirus in <i>Drosophila</i> by Chuan Cao (120553)

“…Using high-resolution genetic mapping we have identified a naturally occurring polymorphism in a gene called <i>Ge-1</i> that makes <i>Drosophila melanogaster</i> highly resistant to its natural pathogen <i>Drosophila melanogaster</i> sigma virus (DMelSV). …”

The Expression of Tubulin Cofactor A (TBCA) Is Regulated by a Noncoding Antisense <em>Tbca</em> RNA during Testis Maturation by Sofia Nolasco (144740)

“…We propose that this regulatory mechanism operates during spermatogenesis, a process that involves microtubule rearrangements, the assembly of specific microtubule structures and requires critical TBCA levels.…”