Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Chloro Half-Sandwich Osmium(II) Complexes:  Influence of Chelated N,N-Ligands on Hydrolysis, Guanine Binding, and Cytotoxicity by Anna F. A. Peacock (1297842)

“…Relatively little is known about the kinetics or the pharmacological potential of organometallic complexes of osmium compared to its lighter congeners, iron and ruthenium. We report the synthesis of seven new complexes, [(η⁶-arene)Os(NN)Cl]⁺, containing different bidentate nitrogen (N,N) chelators, and a dichlorido complex, [(η⁶-arene)Os(N)Cl₂]. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. …”

Additional file 5 of Decreased complement 4 and interleukin-10 as biomarkers in aqueous humour for non-exudative age-related macular degeneration: a case control study by Juliane Schikora (20871169)

LPS dose-dependently decreases T cell proliferative response to OKT3. by Fanny Poujol (834338)

GluN2A(D731N) decreases channel open probability. by Kai Gao (120150)

“…The di-heteromeric mutant (2A-D731N) and tri-heteromeric receptors with two-copies of the mutant subunit (D731N/D731N) showed a prolonged inhibition rate, reflecting a decreased channel open probability. …”

Decreased IFNγ production by NK cells in A-<i>Ly49h</i> mice occurs independently of the NKC and H2 and is linked to MCMV susceptibility. by Nassima Fodil (669326)

Boxplots comparing KGE_mean values of every scenario group (a-e) for calibration, where the black star is showing the mean. by Fabian Mitze (21084251)

Porcupine plots of the PCA analysis depicting the movement and altitude of the C-alpha atoms throughout the 50 ns simulation in the native and mutant complexes. by Sneha P. (3926957)

Decreased phagocytosis of <i>Y. pestis</i> in bone marrow derived macrophages (BMMs) and neutrophils (BMNs) from <i>Irf3^−/−</i> mice. by Ami A. Patel (149580)