Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Table 2_A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical stud... by Xiao-Min Lv (21575681)

“…Moreover, a decrease in malondialdehyde (SMD = −9.29,95% Cl = [−12.84, −5.74], p < 0.00001), reactive oxygen species level (SMD = −4.29,95% Cl = [-6.25, −2.32], p < 0.0001), cyclooxygenase-2 (SMD = −2.66, 95% Cl = [−4.01, −1.30], p =0.0001), tumour necrosis factor-α(SMD = −3.96,95% Cl = [−6.27, −1.65], p = 0.0008) and interleukin-6 (SMD = −3.32,95% Cl = [−4.20, −2.44], p < 0.00001) was observed. …”

Table 1_A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical stud... by Xiao-Min Lv (21575681)

“…Moreover, a decrease in malondialdehyde (SMD = −9.29,95% Cl = [−12.84, −5.74], p < 0.00001), reactive oxygen species level (SMD = −4.29,95% Cl = [-6.25, −2.32], p < 0.0001), cyclooxygenase-2 (SMD = −2.66, 95% Cl = [−4.01, −1.30], p =0.0001), tumour necrosis factor-α(SMD = −3.96,95% Cl = [−6.27, −1.65], p = 0.0008) and interleukin-6 (SMD = −3.32,95% Cl = [−4.20, −2.44], p < 0.00001) was observed. …”

Effects of drug treatments on culture cells and embryos. by Xiaowen Jiang (8291814)

Number of Nepalese Gurkha recruits arriving in the UK and undergoing screening for GIP, each year from 2012–2020. by William D. Nevin (17854751)

Combustion Characteristics of C₅ Alcohols and a Skeletal Mechanism for Homogeneous Charge Compression Ignition Combustion Simulation by Sungwoo Park (1234614)

“…C₅ alcohol blending in PRF75 in HCCI combustion leads to a significant decrease of low-temperature heat release (LTHR) and a delay of the main combustion. …”

Combustion Characteristics of C₅ Alcohols and a Skeletal Mechanism for Homogeneous Charge Compression Ignition Combustion Simulation by Sungwoo Park (1234614)

“…C₅ alcohol blending in PRF75 in HCCI combustion leads to a significant decrease of low-temperature heat release (LTHR) and a delay of the main combustion. …”

Combustion Characteristics of C₅ Alcohols and a Skeletal Mechanism for Homogeneous Charge Compression Ignition Combustion Simulation by Sungwoo Park (1234614)

“…C₅ alcohol blending in PRF75 in HCCI combustion leads to a significant decrease of low-temperature heat release (LTHR) and a delay of the main combustion. …”

Confocal images of oAβ internalization by astrocytes in NG and HG mixed glia cultures. by Yung-Cheng Huang (3443450)

Subjects:

Internalized oAβ puncta colocalize with lysosomes in NG and HG mixed glia cultures. by Yung-Cheng Huang (3443450)

Subjects:

Adsorption of Fumaramide [2]Rotaxane and Its Components on a Solid Substrate:  A Coverage-Dependent Study by Caroline M. Whelan (2529898)

“…A decrease in film order and the absence of a preferred molecular orientation is observed for all three molecules at multilayer coverages. …”

Adsorption of Fumaramide [2]Rotaxane and Its Components on a Solid Substrate:  A Coverage-Dependent Study by Caroline M. Whelan (2529898)

“…A decrease in film order and the absence of a preferred molecular orientation is observed for all three molecules at multilayer coverages. …”

Adsorption of Fumaramide [2]Rotaxane and Its Components on a Solid Substrate:  A Coverage-Dependent Study by Caroline M. Whelan (2529898)

“…A decrease in film order and the absence of a preferred molecular orientation is observed for all three molecules at multilayer coverages. …”

Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis by Joel Eriksson (149940)

“…</p><p>Results</p><p>1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone (IV ratio: -0.25, 95% CI: -0.42–-0.09, p = 2.8*10⁻³). …”

Acoustic or tactile startle responses [V_max (mean ± SEM)] with or without acoustic or light prepulses. by Michael T. Williams (357796)

Gastrointestinal parasite (GIP) infections identified in 2,263 Nepalese Gurkha recruits who had recently migrated to the UK between 2012 and 2020, showing number of infections, per... by William D. Nevin (17854751)

Bar chart and logistic regression curve of yearly prevalence of <i>G</i>. <i>duodenalis</i> infection prevalence in Nepalese Gurkha recruits who migrated to the UK 2012–2020. Logis... by William D. Nevin (17854751)

Thermotactic behavior is reproduced by a variety of neuroanatomical models. by Muneki Ikeda (5166362)

Cumulative percentage of positive diagnoses of hookworm species, using either FEA concentration and light microscopy alone, charcoal culture alone, or both methodologies, depending... by William D. Nevin (17854751)