Discovery of Oral AMP-Activated Protein Kinase Activators for Treating Hyperlipidemia by Mingchao Wang (450503)

“…A single dose of V1 (2000 mg) increased AMPK activation in human erythrocytes after 5 and 12 h of treatment. …”

PON2 gene expression exhibits similar trends to the PON2 protein concentration levels measured using Western blot, with a trend towards decreased PON expression in asthma-obese (n = 5, 11.6 ± 0.22; mean ± standard error in VST-normalized messenger RNA levels) compared to lean participants (n = 4, 11.9 ± 0.062). by Daniel Efrain Winnica (12239641)

Gu-4 improves survival in septic rats and this improvement is accompanied by marked decrease of HMGB1 and TNF-α level in serum. by HuiTing Zhou (333755)

<i>Aspergillus flavus</i> mRNA expression (a) <i>aflD</i> and (c) <i>aflR</i> and phylogenetic analysis of (b) <i>aflD</i> and (d) <i>aflR</i> after exposure to 50 mg/mL of <i>U. e... by Martha Cebile Jobe (21175426)

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response by N.N. Dang (6513023)

“…Filaggrin silencing also resulted in significant increases of IL-2, IL-4, IL-5, and IL-13 (P<0.05 or P<0.01), and significant decreases of IL-12p70 and IFN-γ (P<0.01) compared with cells in the Blank and NC groups. …”

DataSheet_5_Causality between sarcopenia and diabetic nephropathy: a bidirectional Mendelian randomization study.csv by Linan Ren (5561837)

“…</p>Results<p>According to a forward MR analysis, a genetically predicted decrease in appendicular lean mass is associated with an increased risk of developing DN risk (inverse variance weighting[IVW]: odd ratio [OR] = 0.863, 95% confidence interval [CI] 0.767-0.971; P = 0.014). …”

Results of a dog’s detections after exposure to sweat samples from positive and negative people to SARS-CoV-2, together with the Ct values of the RT-qPCR test of each person partic... by Víctor M. Vidal-Martínez (18707335)

miR-10b expression positively correlates with B-Raf^V600E mutation status in multiple cell lines. by Ila Datar (433874)

mRNA expression of 7 genes in normal and colorectal cancer biopsy (A) and in HT29 cells after 5-aza-2’-deoxycytidine treatment (B). by Árpád V. Patai (132272)

“…<p><b>A.</b> Compared to normal, CRC showed decreased mRNA expression. …”

Supplementary Material for: Adiponectin Signaling and Impaired GTPase Rab5 Expression in Adipocytes of Adolescents with Obesity by Karvela A. (9534653)

High glucose-containing media attenuates the degradation of internalized oAβ in mixed glia cultures. by Yung-Cheng Huang (3443450)

Subjects:

Lysosomal hydrolase activities of astrocytes and microglia in mixed glia are quantified in a cell type-specific manner. by Yung-Cheng Huang (3443450)

Subjects:

Effect of 4‑HNE Modification on ZU5-ANK Domain and the Formation of Their Complex with β‑Spectrin: A Molecular Dynamics Simulation Study by Antistio Alviz-Amador (8174016)

“…However, effects at the atomic level of this carbonylation on structure and function of modified protein are not yet fully understood. We present a study based on molecular dynamics simulations of nine 4-HNE modified residues of the ZU5-ANK ankyrin domain with β-spectrin and their binding energy profiles. …”

Effect of 4‑HNE Modification on ZU5-ANK Domain and the Formation of Their Complex with β‑Spectrin: A Molecular Dynamics Simulation Study by Antistio Alviz-Amador (8174016)

“…However, effects at the atomic level of this carbonylation on structure and function of modified protein are not yet fully understood. We present a study based on molecular dynamics simulations of nine 4-HNE modified residues of the ZU5-ANK ankyrin domain with β-spectrin and their binding energy profiles. …”

Effect of 4‑HNE Modification on ZU5-ANK Domain and the Formation of Their Complex with β‑Spectrin: A Molecular Dynamics Simulation Study by Antistio Alviz-Amador (8174016)

“…However, effects at the atomic level of this carbonylation on structure and function of modified protein are not yet fully understood. We present a study based on molecular dynamics simulations of nine 4-HNE modified residues of the ZU5-ANK ankyrin domain with β-spectrin and their binding energy profiles. …”

Downregulation of <i>wnt5b</i> during gastrulation by <i>lbx1b</i> overexpression. by Long Guo (548453)

“…<p>(A) <i>In situ</i> hybridization for non-canonical Wnt/PCP ligands (<i>wnt5b</i> and <i>wnt11</i>) in control and <i>lbx1b</i>-overexpressing embryos at 90% epiboly. …”

miR-10b confers anchorage-independence and increases invasive capacity of melanoma cell lines. by Ila Datar (433874)

Intensification of Antiretroviral Therapy with a CCR5 Antagonist in Patients with Chronic HIV-1 Infection: Effect on T Cells Latently Infected by Carolina Gutiérrez (192894)

B-Raf^V600E melanoma cells acquire cancer phenotypes partly by increasing the expression levels of miR-10b. by Ila Datar (433874)

“…<p>(a) Upper panel: B-Raf^V600E knockdown decreases number of colonies in soft agar in sk-mel-28 cell line. …”

Prediction errors of SVD entropy. by Francis Banville (13569659)

“…<p>Difference in SVD entropy between maximum entropy and empirical food webs as a function of (a) the number of interactions, (b) connectance, and (c) species richness. …”