Data Sheet 1_Bioinformatics combined with machine learning unravels differences among environmental, seafood, and clinical isolates of Vibrio parahaemolyticus.pdf حسب Shuyi Feng (6315239)

"…Comparison of genomes of all seafood-clinical isolates showed high balanced accuracy (≥0.80) and Area Under the Receiver Operating Characteristics curve (≥0.87) for all of these functional features. Major virulence factors including tdh, trh, type III secretion system-related genes, and four alpha-hemolysin genes (hlyA, hlyB, hlyC, and hlyD) were identified as important differentiating factors in our seafood-clinical virulence model, underscoring the need for further investigation. …"

Data Sheet 1_TGM2 regulated by transcription factor NR3C1 drives p38 MAPK-mediated tumor progression and immune evasion in lung squamous cell carcinoma.zip حسب Chunlong Lin (18931437)

"…Key genes were screened via random forest algorithm. Functional validation was performed in NCI-H520 and SK-MES-1 cell lines. …"

Supporting data for "Machine learning based prognosis prediction of intracerebral hemorrhage outcome". حسب Eunhye Yang (17853260)

"…The resulting prognosis prediction ML model, based on Random Forest algorithm, achieved an overall accuracy of 0.81, with AUROCs of 0.93, 0.84 and 0.95 for good, poor, and death outcomes, respectively. …"

Data Sheet 1_Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma.do... حسب Xuan Xu (781842)

"…Key hub genes, such as HS6ST3 and TUBB2B, were identified across different cellular subpopulations, highlighting a cell-specific co-expression network linked to mitochondrial function.…"

Table 1_Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma.xlsx حسب Xuan Xu (781842)

"…Key hub genes, such as HS6ST3 and TUBB2B, were identified across different cellular subpopulations, highlighting a cell-specific co-expression network linked to mitochondrial function.…"

Image 3_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif حسب Yunpeng Zou (3723007)

"…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …"

Image 2_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif حسب Yunpeng Zou (3723007)

"…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …"

Image 4_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif حسب Yunpeng Zou (3723007)

"…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …"

Image 5_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif حسب Yunpeng Zou (3723007)

"…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …"

Image 1_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif حسب Yunpeng Zou (3723007)

"…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …"

Data Sheet 1_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.zip حسب Yunpeng Zou (3723007)

"…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …"

Data Sheet 2_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.pdf حسب Yunpeng Zou (3723007)

"…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …"

Transcription factor of Key regulator genes. حسب Kankana Bhattacharjee (20623639)

"…Our analysis revealed 33 key regulators were predominantly enriched in neuroactive ligand-receptor interaction, Cell adhesion molecules, Leukocyte transendothelial migration pathways; positive regulation of cell proliferation, positive regulation of protein kinase B signaling biological functions; G-protein beta-subunit binding, receptor binding molecular functions etc. …"

Gene-drug interaction of the key regulators. حسب Kankana Bhattacharjee (20623639)

"…Our analysis revealed 33 key regulators were predominantly enriched in neuroactive ligand-receptor interaction, Cell adhesion molecules, Leukocyte transendothelial migration pathways; positive regulation of cell proliferation, positive regulation of protein kinase B signaling biological functions; G-protein beta-subunit binding, receptor binding molecular functions etc. …"

Table 1_Developing models for the diagnosing of ulcerative colitis and prognosis of anti-TNF-α non-response based on neutrophil extracellular trap-associated genes.docx حسب Jinyuan Ou (22163431)

"…A diagnostic model for UC was constructed using five hub genes (FCGR3B, IL1RN, CXCL8, S100A8, and S100A9) derived from C1. …"

Risk of Bias 2 Assessment: BoNT-A versus Placebo حسب Anita R Gross (9363502)

"…<p dir="ltr">The Risk of Bias 2 (RoB 2) tool was employed to assess the methodological quality of included studies for botulinum toxin A versus placebo. …"

Table 1_Identification of cellular senescence-related genes as biomarkers for lupus nephritis based on bioinformatics.docx حسب Wei Chen (23863)

"…The three biomarkers were enriched in “B Cell receptor signaling pathway” and “NF−kappa B signaling pathway” based on GESA results.…"

Image 2_Construction and clinical visualization application of a predictive model for mortality risk in sepsis patients based on an improved machine learning model.jpeg حسب Ting Chen (15205)

"…</p>Results<p>The improved algorithm significantly outperformed other algorithms on 23 standard test functions. …"

Image 1_Machine learning-driven discovery of NETs-associated diagnostic biomarkers and molecular subtypes in tuberculosis.tif حسب Shoupeng Ding (21555394)

"…Consensus clustering based on the expression profiles of these core genes stratified patients into two distinct subtypes. Functional enrichment analysis further underscored the predominance of immune-related pathways in subtype B. …"

Image 3_Construction and clinical visualization application of a predictive model for mortality risk in sepsis patients based on an improved machine learning model.jpeg حسب Ting Chen (15205)

"…</p>Results<p>The improved algorithm significantly outperformed other algorithms on 23 standard test functions. …"