Image 1_Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis.tif by Shangrui Rao (18189241)

“…</p>Methods<p>A distinct binding pocket (Pocket 1–5) within the PXR ligand-binding domain was identified using a multi-algorithm computational approach (SiteMap, Fpocket, Prank, CASTpFold). …”

Image 2_Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis.tif by Shangrui Rao (18189241)

“…</p>Methods<p>A distinct binding pocket (Pocket 1–5) within the PXR ligand-binding domain was identified using a multi-algorithm computational approach (SiteMap, Fpocket, Prank, CASTpFold). …”

Image 3_Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis.tif by Shangrui Rao (18189241)

“…</p>Methods<p>A distinct binding pocket (Pocket 1–5) within the PXR ligand-binding domain was identified using a multi-algorithm computational approach (SiteMap, Fpocket, Prank, CASTpFold). …”

Image 4_Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis.tif by Shangrui Rao (18189241)

“…</p>Methods<p>A distinct binding pocket (Pocket 1–5) within the PXR ligand-binding domain was identified using a multi-algorithm computational approach (SiteMap, Fpocket, Prank, CASTpFold). …”

Data Sheet 1_Impaired and restored CD8+ T cell responses to a sequentially mutated spike epitope in Omicron variants.docx by Eun Joo Chung (9678137)

“…Our findings suggest that LYN may function both as an immune-evasive hotspot and as a cross-reactive epitope, underscoring the importance of continued epitope-level surveillance as future variants emerge.…”

DataSheet1_Identification of novel markers for neuroblastoma immunoclustering using machine learning.zip by Longguo Zhang (20105238)

“…Three machine learning algorithms (LASSO, SVM-RFE, and Random Forest) were used to screen biomarkers and synthesize their function in neuroblastoma.…”

Data Sheet 1_TGM2 regulated by transcription factor NR3C1 drives p38 MAPK-mediated tumor progression and immune evasion in lung squamous cell carcinoma.zip by Chunlong Lin (18931437)

“…Key genes were screened via random forest algorithm. Functional validation was performed in NCI-H520 and SK-MES-1 cell lines. …”

Data Sheet 1_Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics.pdf by Yuexi Yu (21158744)

“…Immune cell infiltration was analyzed using the CIBERSORT algorithm. Finally, RT-qPCR experiments were conducted to validate the expression of key genes.…”

Table 1_Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics.xlsx by Yuexi Yu (21158744)

“…Immune cell infiltration was analyzed using the CIBERSORT algorithm. Finally, RT-qPCR experiments were conducted to validate the expression of key genes.…”

Table 2_Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics.xlsx by Yuexi Yu (21158744)

“…Immune cell infiltration was analyzed using the CIBERSORT algorithm. Finally, RT-qPCR experiments were conducted to validate the expression of key genes.…”

DataSheet1_Integration of transcriptomics and machine learning for insights into breast cancer: exploring lipid metabolism and immune interactions.docx by Xiaohan Chen (384089)

“…Our study revealed distinct biological functions and mutation landscapes between high-scoring and low-scoring patients. …”

Image 3_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif by Yunpeng Zou (3723007)

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”

Image 2_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif by Yunpeng Zou (3723007)

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”

Image 4_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif by Yunpeng Zou (3723007)

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”

Image 5_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif by Yunpeng Zou (3723007)

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”

Image 1_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.tif by Yunpeng Zou (3723007)

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”

Data Sheet 1_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.zip by Yunpeng Zou (3723007)

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”

Data Sheet 2_The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target.pdf by Yunpeng Zou (3723007)

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”

Table1_“Dictionary of immune responses” reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.xls by Peichuan Xu (19862055)

“…Cell–cell communication analysis uncovered alteration in ANNEXIN pathway and a reduction in CXCL signaling between macrophages and monocytes, suggesting immune response dysregulation. Furthermore, ten algorithms identified three hub genes. Both experiments conducted in vitro and in vivo have conclusively shown that IRF7 serves as a crucial target for the treatment of IDD, and its knockdown alleviates IDD. …”

Image2_“Dictionary of immune responses” reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration.jpeg by Peichuan Xu (19862055)

“…Cell–cell communication analysis uncovered alteration in ANNEXIN pathway and a reduction in CXCL signaling between macrophages and monocytes, suggesting immune response dysregulation. Furthermore, ten algorithms identified three hub genes. Both experiments conducted in vitro and in vivo have conclusively shown that IRF7 serves as a crucial target for the treatment of IDD, and its knockdown alleviates IDD. …”