Supplementary file 1_Single-cell and bulk transcriptomic analyses reveal PANoptosis-associated immune dysregulation of fibroblasts in periodontitis.zip by Erli Wu (17785482)

“…By integrating bulk transcriptomic data with machine learning algorithms, we identified and validated key PANoptosis-related genes, highlighting their potential as novel therapeutic targets.…”

Table1_Comprehensive pan-cancer analysis and experiments revealed R3HDM1 as a novel predictive biomarker for prognosis and immune therapy response.DOCX by Jiawei Liu (553742)

“…High expression of R3HDM1 was linked to poor prognosis across different tumors and altered drug sensitivity. …”

Data Sheet 1_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 5_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.csv by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Supplementary file 1_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.docx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 2_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 3_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Data Sheet 4_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx by Wentong Li (492392)

“…Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.…”

Etodolac utility in osteoarthritis: drug delivery challenges, topical nanotherapeutic strategies and potential synergies by Pavani Gaddala (19761334)

“…Inflammatory processes within OSA joints are regulated by pro-inflammatory and anti-inflammatory cytokines. …”

Image 1_Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics ana... by Zhaokai Zhou (15239078)

“…Moreover, machine learning algorithms were applied to identify novel potential targets for each subtype, and experimentally validate their effects.…”

Table 1_Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics ana... by Zhaokai Zhou (15239078)

“…Moreover, machine learning algorithms were applied to identify novel potential targets for each subtype, and experimentally validate their effects.…”

Image 2_Characterization of cancer-related fibroblasts in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics ana... by Zhaokai Zhou (15239078)

“…Moreover, machine learning algorithms were applied to identify novel potential targets for each subtype, and experimentally validate their effects.…”

Raw LC-MS/MS and RNA-Seq Mitochondria data by Stefano Martellucci (16284377)

“…Differentially altered pathways were evaluated by using the enrich plot package in R for visualization of functional enrichment (i.e., dot plot).</p>…”

DataSheet1_Mitochondrial-related genes as prognostic and metastatic markers in breast cancer: insights from comprehensive analysis and clinical models.docx by Yutong Fang (16621143)

“…Moreover, leveraging the GSE102484 dataset, we conducted differential gene expression analysis to identify MRGs related to metastasis, subsequently developing metastasis models via 10 distinct machine-learning algorithms and then selecting the best-performing model. …”

Table1_Mitochondrial-related genes as prognostic and metastatic markers in breast cancer: insights from comprehensive analysis and clinical models.xlsx by Yutong Fang (16621143)

“…Moreover, leveraging the GSE102484 dataset, we conducted differential gene expression analysis to identify MRGs related to metastasis, subsequently developing metastasis models via 10 distinct machine-learning algorithms and then selecting the best-performing model. …”

FAR1 as a ferroptosis-related biomarker and potential therapeutic target in acute kidney injury: integrated bioinformatics and experimental validation by Hao Duan (8386146)

“…Differentially expressed FRGs linked to AKI were identified through analytical methods, followed by an examination of their biological functions. …”

Bioinformatics-based screening and experimental validation of biomarkers for the treatment of connective tissue-associated interstitial lung disease with liquorice and dried ginger... by Hui Yuan (402180)

“…</p> <p>Five biomarkers (CXCL8, IL1A, IL1B, NFE2L2, and PTGS2) were identified. Functional analysis linked these pathways to innate immunity, cytokine activity, and pertussis pathways. …”

Image 5_Single-cell and machine learning-based pyroptosis-related gene signature predicts prognosis and immunotherapy response in glioblastoma.tif by Liren Fang (22489516)

“…Pyroptosis, an inflammatory form of programmed cell death, has been increasingly linked to tumor immunity and progression; however, its molecular roles and clinical implications in GBM remain insufficiently understood.…”

Image 3_Single-cell and machine learning-based pyroptosis-related gene signature predicts prognosis and immunotherapy response in glioblastoma.tif by Liren Fang (22489516)

“…Pyroptosis, an inflammatory form of programmed cell death, has been increasingly linked to tumor immunity and progression; however, its molecular roles and clinical implications in GBM remain insufficiently understood.…”

Table 2_Single-cell and machine learning-based pyroptosis-related gene signature predicts prognosis and immunotherapy response in glioblastoma.xlsx by Liren Fang (22489516)

“…Pyroptosis, an inflammatory form of programmed cell death, has been increasingly linked to tumor immunity and progression; however, its molecular roles and clinical implications in GBM remain insufficiently understood.…”