Data Sheet 1_Case Report: Myelodysplastic/myeloproliferative neoplasm with concurrent SF3B1, ASXL1, JAK2 and CBL mutations and <15% bone marrow ringed sideroblasts.docx حسب Yifan Wang (380120)

"…Comprehensive genomic profiling revealed a unique quadruple mutation signature: ASXL1 p.G646Wfs*12 (9.8% VAF), JAK2 p.R683G (17.5%), and CBL p.R149Q (16.2%), with preserved karyotype. Functional analyses demonstrated mutation-specific pathobiological crosstalk: 1) SF3B1-mediated mitochondrial iron mislocalization (ALAS2 splicing defects, ABCB7 downregulation) synergized with ASXL1-driven epigenetic repression of erythroid transcription factors (GATA1, KLF1), exacerbating anemia; 2) JAK2 p.R683G’s partial kinase activation combined with CBL-dependent RAS/MAPK signaling sustained thrombocytosis through megakaryocytic hyperplasia. …"

Table 1_Case Report: Myelodysplastic/myeloproliferative neoplasm with concurrent SF3B1, ASXL1, JAK2 and CBL mutations and <15% bone marrow ringed sideroblasts.xlsx حسب Yifan Wang (380120)

"…Comprehensive genomic profiling revealed a unique quadruple mutation signature: ASXL1 p.G646Wfs*12 (9.8% VAF), JAK2 p.R683G (17.5%), and CBL p.R149Q (16.2%), with preserved karyotype. Functional analyses demonstrated mutation-specific pathobiological crosstalk: 1) SF3B1-mediated mitochondrial iron mislocalization (ALAS2 splicing defects, ABCB7 downregulation) synergized with ASXL1-driven epigenetic repression of erythroid transcription factors (GATA1, KLF1), exacerbating anemia; 2) JAK2 p.R683G’s partial kinase activation combined with CBL-dependent RAS/MAPK signaling sustained thrombocytosis through megakaryocytic hyperplasia. …"

Data Sheet 2_Case Report: Myelodysplastic/myeloproliferative neoplasm with concurrent SF3B1, ASXL1, JAK2 and CBL mutations and <15% bone marrow ringed sideroblasts.pdf حسب Yifan Wang (380120)

"…Comprehensive genomic profiling revealed a unique quadruple mutation signature: ASXL1 p.G646Wfs*12 (9.8% VAF), JAK2 p.R683G (17.5%), and CBL p.R149Q (16.2%), with preserved karyotype. Functional analyses demonstrated mutation-specific pathobiological crosstalk: 1) SF3B1-mediated mitochondrial iron mislocalization (ALAS2 splicing defects, ABCB7 downregulation) synergized with ASXL1-driven epigenetic repression of erythroid transcription factors (GATA1, KLF1), exacerbating anemia; 2) JAK2 p.R683G’s partial kinase activation combined with CBL-dependent RAS/MAPK signaling sustained thrombocytosis through megakaryocytic hyperplasia. …"

3D analysis of the perforated pebbles and the perforations. حسب Talia Yashuv (12883867)

Data Sheet 1_Simplified two-compartment neuron with calcium dynamics capturing brain-state specific apical-amplification, -isolation and -drive.pdf حسب Elena Pastorelli (7024235)

"…A machine learning evolutionary algorithm, guided by a set of fitness functions, selected parameters defining neurons that express the desired apical dendritic mechanisms. …"

IEEE Big Data 2024 Presentation: Norma: A Framework for Finding Threshold Associations Between Continuous Variables Using Point-wise Function حسب Md Mahin (21434966)

"…Norma introduces the unique Continuous Variable Threshold (CVT) pattern, aiming to identify a pair of thresholds within the value domain of two continuous variables, revealing strong associations within a specified geographic area. …"

Gated Feedforward Network (GDFN) Structure. حسب Xuanming Wang (22184274)

"…By labeling image edges and noise, and utilizing neighborhood based wavelet coefficient shrinkage algorithm, the noise interference in the image is effectively reduced; preliminary enhancement was performed on the denoised image, using Retinex algorithm combined with bilateral filtering method to estimate illuminance, and Sigmoid function was used to enhance the reflection area, improving the overall visual effect of the image. …"

Pixel perception module structure. حسب Xuanming Wang (22184274)

"…By labeling image edges and noise, and utilizing neighborhood based wavelet coefficient shrinkage algorithm, the noise interference in the image is effectively reduced; preliminary enhancement was performed on the denoised image, using Retinex algorithm combined with bilateral filtering method to estimate illuminance, and Sigmoid function was used to enhance the reflection area, improving the overall visual effect of the image. …"

Infrared night vision image test sample. حسب Xuanming Wang (22184274)

"…By labeling image edges and noise, and utilizing neighborhood based wavelet coefficient shrinkage algorithm, the noise interference in the image is effectively reduced; preliminary enhancement was performed on the denoised image, using Retinex algorithm combined with bilateral filtering method to estimate illuminance, and Sigmoid function was used to enhance the reflection area, improving the overall visual effect of the image. …"

Data Sheet 4_Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer.zip حسب Rui Wang (52434)

"…However, the prognostic and functional contributions of distinct CAF subtypes remain inadequately understood. …"

Data Sheet 3_Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer.zip حسب Rui Wang (52434)

"…However, the prognostic and functional contributions of distinct CAF subtypes remain inadequately understood. …"

Data Sheet 1_Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer.zip حسب Rui Wang (52434)

"…However, the prognostic and functional contributions of distinct CAF subtypes remain inadequately understood. …"

Data Sheet 6_Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer.zip حسب Rui Wang (52434)

"…However, the prognostic and functional contributions of distinct CAF subtypes remain inadequately understood. …"

Data Sheet 7_Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer.zip حسب Rui Wang (52434)

"…However, the prognostic and functional contributions of distinct CAF subtypes remain inadequately understood. …"

Data Sheet 5_Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer.zip حسب Rui Wang (52434)

"…However, the prognostic and functional contributions of distinct CAF subtypes remain inadequately understood. …"

Data Sheet 2_Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer.zip حسب Rui Wang (52434)

"…However, the prognostic and functional contributions of distinct CAF subtypes remain inadequately understood. …"

GO and KEGG analysis. حسب Wan-Jing Zhen (20427813)

Factors influencing the discovery of new genetic signatures. حسب Wei Liu (20030)

Optimal progressively censored reliability sampling plans for log-location-scale distributions حسب Chien-Tai Lin (22673615)

"…<p>Here, we introduce a variable neighborhood search algorithm-based approach to determine the minimum sample sizes required for progressively censored reliability sampling plans within the flexible family of log-location-scale family of distributions, which includes Weibull and log-logistic distributions. …"

Temporal analysis of epithelial cells. حسب Yanfeng Xue (465345)