Table1_Mitochondrial DNA mutations can influence the post-implantation development of human mosaic embryos.xlsx by Akifumi Ijuin (16817115)

“…We hypothesized that mitochondrial function, one of the most critical factors for embryonic development, can influence human post-implantation embryonic development, including a decrease of aneuploid cells in mosaic embryos.…”

Table5_Mitochondrial DNA mutations can influence the post-implantation development of human mosaic embryos.DOCX by Akifumi Ijuin (16817115)

“…We hypothesized that mitochondrial function, one of the most critical factors for embryonic development, can influence human post-implantation embryonic development, including a decrease of aneuploid cells in mosaic embryos.…”

Both monosomies and trisomies decrease cellular fitness. by Dorine C. Hintzen (12988183)

DataSheet_1_Impact of endometrial compaction on reproductive outcomes after cryotransfer of euploid embryos in a modified natural cycle: protocol for a prospective cohort study.pdf by Esperanza De la Torre Perez (17363236)

Table_2_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertili... by Sandro C. Esteves (5143712)

Table_1_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertili... by Sandro C. Esteves (5143712)

Table_3_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertili... by Sandro C. Esteves (5143712)

Data_Sheet_1_A Novel Predictive Model to Estimate the Number of Mature Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fe... by Sandro C. Esteves (5143712)

MtDNA replacement in human oocytes with MRR-SCCT procedure. by Xiaoyu Liao (8161995)

MtDNA carryover removal and SCC integraty by MRR manipulation in mouse oocytes. by Xiaoyu Liao (8161995)

MtDNA residual levels and chromosomal copy numbers in mouse SCC transferred blastocysts. by Xiaoyu Liao (8161995)

Image_1_Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome.tif by Alessandra Maria Adelaide Chiotto (7482065)

“…Conversely, our analysis highlighted differences between trisomic and euploid neurons in terms of reduction of spine density, in accordance with in vivo data obtained by other groups, proposing the presence of a cell-intrinsic malfunction. …”

Single allele dysfunction of <i>ERG251</i> in combination with concurrent aneuploidy causes azole resistance. by Xin Zhou (54275)

SNARE proteins rescue impaired autophagic flux in Down syndrome by Stefanos Aivazidis (3944795)

“…Based on our previous observations of PN disruption in DS, we investigated possible dysfunction of the autophagic machinery in human DS fibroblasts and other DS cell models. Following induction of autophagy by serum starvation, DS fibroblasts displayed impaired autophagic flux indicated by autophagolysosome accumulation and elevated p62, NBR1, and LC3-II abundance, compared to age- and sex-matched, euploid (CTL) fibroblasts. …”

Virtual-Partition Digital PCR for High-Precision Chromosomal Counting Applications by Lucien Jacky (10197624)

“…This demonstration assaytested on 432 samples contrived from sheared cell-line DNA at multiple input concentrations and simulated fractions of euploid or trisomy-21 “fetal” DNAis analyzed using both traditional dPCR thresholding and VPdPCR. …”

Genome instability in STRIPAK complex mutants. by Patricia P. Peterson (20291306)

“…<p>(A) Read depth analyses from whole-genome sequencing of the WT/WT (CnLC6683) parental diploid strain and heterozygous mutant diploid strains. The WT/WT genome is euploid, while <i>PPH22/pph22</i>Δ and <i>MOB3/mob3</i>Δ strains exhibit multiple instances of segmental and whole chromosome aneuploidy, with dark blue and orange highlighting regions/chromosomes with increased and decreased read depth, respectively. …”

Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas by Christopher D. Laucius (6816569)

“…<p>Chromosomal instability (CIN) is defined as a high rate of whole chromosome loss or gain and is a hallmark of many aneuploid solid tumors. …”

Supplementary Figure S1 from Cellular Prion Protein PrP^C and Ecto-5′-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy by Patrícia H. Domingues (14925828)

“…<p>Hierarchical clustering analysis of multiple cell surface markers in aneuploid cell lines. The expression of 291 cell surface markers (each row represents a single protein) in 5 different aneuploid cell lines (each column represents a different cell line, namely RPE1 5/3 12/3 - trisomy of chromosome 5 and 12 -, RPE1 21/3 - trisomy of chromosome 21 -, HCT116 5/3 - trisomy of chromosome 5 -, RPT1 - RPE1 post-tetraploid clone -, HPT1 - HCT116 post-tetraploid clone -) is shown in a matrix format. …”

Image1_Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors.PDF by Dun Liu (674970)

“…</p>Results<p>A total of 100 blastocysts were biopsied and analyzed in 15 CCR couples after 17 PGT-SR cycles, with 16.0% being euploid, 78.0% aneuploid and 6.0% mosaic. 11 normal/balanced embryos and one mosaic embryo were transferred, resulting in eight live births. …”

Table1_Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors.PDF by Dun Liu (674970)

“…</p>Results<p>A total of 100 blastocysts were biopsied and analyzed in 15 CCR couples after 17 PGT-SR cycles, with 16.0% being euploid, 78.0% aneuploid and 6.0% mosaic. 11 normal/balanced embryos and one mosaic embryo were transferred, resulting in eight live births. …”