Table_6_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx حسب Beatrice Vione (10734998)

"…</p>Results<p>Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. …"

Table_9_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx حسب Beatrice Vione (10734998)

"…</p>Results<p>Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. …"

Table_2_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx حسب Beatrice Vione (10734998)

"…</p>Results<p>Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. …"

Table_6_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx حسب Beatrice Vione (10734998)

"…</p>Results<p>Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. …"

Table_1_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx حسب Beatrice Vione (10734998)

"…</p>Results<p>Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. …"

Data_Sheet_2_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.DOCX حسب Beatrice Vione (10734998)

"…</p>Results<p>Results highlight specific alterations of THF with a median concentration ratio DS/control of 2:3, a decrease of a necessary molecule perfectly consistent with a chromosomal dosage effect. …"

Table_4_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.DOCX حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Table_2_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.DOCX حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Table_3_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.XLSX حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Image_1_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.TIF حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Table_1_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.DOCX حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Image_3_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.TIF حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Image_2_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.TIF حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Image_4_Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis.TIFF حسب Liu-liu Sun (15205327)

"…Tolerance to 5-flucytosine might be due to the decreased expression of FUR1. Therefore, the pleiotropic effect of aneuploidy on antifungal tolerance was due to the simultaneous regulation of genes on the aneuploid chromosome and genes on euploid chromosomes. …"

Image_1_Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome.tif حسب Alessandra Maria Adelaide Chiotto (7482065)

"…Conversely, our analysis highlighted differences between trisomic and euploid neurons in terms of reduction of spine density, in accordance with in vivo data obtained by other groups, proposing the presence of a cell-intrinsic malfunction. …"

SNARE proteins rescue impaired autophagic flux in Down syndrome حسب Stefanos Aivazidis (3944795)

"…Following induction of autophagy by serum starvation, DS fibroblasts displayed impaired autophagic flux indicated by autophagolysosome accumulation and elevated p62, NBR1, and LC3-II abundance, compared to age- and sex-matched, euploid (CTL) fibroblasts. While lysosomal physiology was unaffected in both groups after serum starvation, we observed decreased basal abundance of the Soluble N-ethylmaleimide-sensitive-factor Attachment protein Receptor (SNARE) family members syntaxin 17 (STX17) and Vesicle Associated Membrane Protein 8 (VAMP8) indicating that decreased autophagic flux in DS is due at least in part to a possible impairment of autophagosome-lysosome fusion. …"

Virtual-Partition Digital PCR for High-Precision Chromosomal Counting Applications حسب Lucien Jacky (10197624)

"…Each physical partition is then divided into a series of virtual partitions, and the resulting increase in partition count substantially decreases partitioning error. …"

Genome instability in STRIPAK complex mutants. حسب Patricia P. Peterson (20291306)

"…The WT/WT genome is euploid, while <i>PPH22/pph22</i>Δ and <i>MOB3/mob3</i>Δ strains exhibit multiple instances of segmental and whole chromosome aneuploidy, with dark blue and orange highlighting regions/chromosomes with increased and decreased read depth, respectively. …"