Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts by Nobutoshi Nawa (7053758)

“…Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects on organismal growth and development, regardless of the karyotype, suggesting that aneuploidy-associated stress plays an important role in disease pathogenesis. …”

Senescent trisomy fibroblasts showed increased glucose consumption and increased lactate production, suggesting disturbed energy metabolism. by Nobutoshi Nawa (7053758)

Fertilization, clinical pregnancy, and rate of pregnancy loss in relation to paternal age. by Stephanie Cheung (254096)

Genetic and epigenetic profiling of the infertile male by Stephanie Cheung (254096)

Supplementary Figure S1 from Cellular Prion Protein PrP^C and Ecto-5′-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy by Patrícia H. Domingues (14925828)

Supplementary Figure S2 from Cellular Prion Protein PrP^C and Ecto-5′-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy by Patrícia H. Domingues (14925828)

Genome instability in STRIPAK complex mutants. by Patricia P. Peterson (20291306)

“…<p>(A) Read depth analyses from whole-genome sequencing of the WT/WT (CnLC6683) parental diploid strain and heterozygous mutant diploid strains. The WT/WT genome is euploid, while <i>PPH22/pph22</i>Δ and <i>MOB3/mob3</i>Δ strains exhibit multiple instances of segmental and whole chromosome aneuploidy, with dark blue and orange highlighting regions/chromosomes with increased and decreased read depth, respectively. …”

Data_Sheet_1_Modeling Klinefelter Syndrome Using Induced Pluripotent Stem Cells Reveals Impaired Germ Cell Differentiation.PDF by Olivier Botman (318798)

“…This reduced ability to generate germ cells was not associated with a decrease of proliferation of 47XXY-iPSC-derived cells but rather with an increase of cell death upon germ cell differentiation as revealed by an increase of LDH release and of capase-3 expression in 47XXY-iPSC-derived cells. …”

MtDNA replacement in human oocytes with MRR-SCCT procedure. by Xiaoyu Liao (8161995)

MtDNA residual levels and chromosomal copy numbers in mouse SCC transferred blastocysts. by Xiaoyu Liao (8161995)

MtDNA carryover removal and SCC integraty by MRR manipulation in mouse oocytes. by Xiaoyu Liao (8161995)

Image_1_Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome.tif by Alessandra Maria Adelaide Chiotto (7482065)

“…Conversely, our analysis highlighted differences between trisomic and euploid neurons in terms of reduction of spine density, in accordance with in vivo data obtained by other groups, proposing the presence of a cell-intrinsic malfunction. …”

Strains used in this study. by Xin Zhou (54275)

“…Homozygous deletions of <i>ERG251</i> caused increased fitness in low concentrations of fluconazole and decreased fitness in rich medium, especially at low initial cell density. …”

Primers used in this study. by Xin Zhou (54275)

“…Homozygous deletions of <i>ERG251</i> caused increased fitness in low concentrations of fluconazole and decreased fitness in rich medium, especially at low initial cell density. …”

<i>ERG251</i> SNPs from all FLC-evolved strains. by Xin Zhou (54275)

“…Homozygous deletions of <i>ERG251</i> caused increased fitness in low concentrations of fluconazole and decreased fitness in rich medium, especially at low initial cell density. …”

Virtual-Partition Digital PCR for High-Precision Chromosomal Counting Applications by Lucien Jacky (10197624)

“…This demonstration assaytested on 432 samples contrived from sheared cell-line DNA at multiple input concentrations and simulated fractions of euploid or trisomy-21 “fetal” DNAis analyzed using both traditional dPCR thresholding and VPdPCR. …”

Data_Sheet_1_TRF1 Depletion Reveals Mutual Regulation Between Telomeres, Kinetochores, and Inner Centromeres in Mouse Oocytes.PDF by Hyuk-Joon Jeon (11448082)

Table_3_Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transc... by Weijie Yang (3625022)

“…Acute DNA damage and acceleration of the activation of primordial follicles after CTX treatment were repaired within several days, but the remaining follicle numbers remarkably decrease. Although partial surviving primordial follicle were developed to mature oocyte, oocyte quality hemostasis was impaired exhibiting aberrant meiosis progression, abnormal spindle and aneuploidy, mitochondrial dysfunction and increased endoplasmic reticulum stress. …”

Table_2_Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transc... by Weijie Yang (3625022)

“…Acute DNA damage and acceleration of the activation of primordial follicles after CTX treatment were repaired within several days, but the remaining follicle numbers remarkably decrease. Although partial surviving primordial follicle were developed to mature oocyte, oocyte quality hemostasis was impaired exhibiting aberrant meiosis progression, abnormal spindle and aneuploidy, mitochondrial dysfunction and increased endoplasmic reticulum stress. …”

Image_1_Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transc... by Weijie Yang (3625022)

“…Acute DNA damage and acceleration of the activation of primordial follicles after CTX treatment were repaired within several days, but the remaining follicle numbers remarkably decrease. Although partial surviving primordial follicle were developed to mature oocyte, oocyte quality hemostasis was impaired exhibiting aberrant meiosis progression, abnormal spindle and aneuploidy, mitochondrial dysfunction and increased endoplasmic reticulum stress. …”