PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer حسب Reem Saleh (3513056)

"…Using functional assays, we confirmed that atezolizumab increases MDA-MB-231 cell apoptosis/necrosis, and reduces their proliferation and viability. …"

MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the... حسب Radhakrishnan Vishnubalaji (3563306)

"…In agreement with our data, SMAD2 expression was downregulated in 47% of patients with soft tissue sarcoma. …"

The Anti-Cancer Effect of Strained Photoactivatable Polypyridyl Ruthenium(II) Complexes on Non-Small-Cell Lung Cancer and Triple Negative Breast Cancer Cells حسب Fayad, Christelle

"…Determination of the octanol-water partition coefficient (log P) of the various complexes revealed that C3 is the most lipophilic which justifies its high cellular uptake and high cytotoxicity. …"
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Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity حسب Mohammed R. Shaker (10316180)

"…These neurons were next exposed to pre-aggregated β-amyloid 1–42 oligomers to model the neurotoxicity associated with Alzheimer’s disease. Our data reveal that upregulation of <i>KLOTHO</i> significantly reduced β-amyloid-induced neuronal degeneration and apoptosis, as evidenced by decreased cleaved caspase-3 expression and preservation of axonal integrity. …"

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer حسب Ghaneya Al-Khadairi (14153274)

"…Gene ontology analyses revealed enrichment of genes that are dysregulated in ovarian and esophageal cancer and are involved in transcription and apoptosis. In line with this, interrogation of TCGA and GTEx data demonstrated an increased PRAME expression in ovarian and esophageal tumor tissues in addition to breast tumors where it is associated with worse survival. …"

Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar حسب Rasha.S.Abo, El Alaa

"…Herbalists’ demographic data and their herbal recommendations for breast cancer treatment were collected through structured interviews. …"
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Inhibition of cytochrome P450 epoxygenase promotes endothelium-to-mesenchymal transition and exacerbates doxorubicin-induced cardiovascular toxicity حسب Hevna Dhulkifle (14724821)

"…Our results showed that MSPPOH exacerbated DOX-induced EndMT, inflammation, oxidative stress, and apoptosis in our endothelial cells. Furthermore, we also show that MSPPOH increased cardiac edema, lowered vascular blood flow velocity, and worsened the expression of EndMT and cardiac injury markers in our zebrafish model of DOX-induced cardiotoxicity.…"