Benzofuranyl-pyrazole as a Novel Scaffold for <i>In Vitro</i> and <i>In Vivo</i> Potent Anticancer Therapeutics That Directly Disrupt the ‘Undruggable’ MYC Oncogene and Potentiate... by Liuqing Yang (128705)

“…Meanwhile, it synergized with a small-molecule immune checkpoint inhibitor <i>in vivo</i>, highlighting its potential application in immunotherapy.…”

Image 4_Unraveling impact and potential mechanisms of baseline pain on efficacy of immunotherapy in lung cancer patients: a retrospective and bioinformatic analysis.jpg by Zexin Zhang (7507979)

“…ELISA assay results indicated that the level of CXCL12 significantly decreased compared to baseline after pain was relieved.…”

Data Sheet 1_Biorefinery—inspired, two-step valorization strategy to manage plant-based recalcitrant organic waste, involving solvent extraction, and fermentation with Bacillus cla... by Sreejith Meppoyilam (20563139)

“…This novel two-step valorization workflow involves the extraction of small molecules using organic solvents, and fermentation of resulting denatured residues (increased biodegradability or decreased recalcitrance) of reduced microbial load. …”

Table 5_Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov.docx by Yinghong Zhou (6873053)

“…</p>Conclusion<p>In the last ten years, registered pediatric drug trials have either stayed stable or slightly decreased, often featuring small sample sizes and rarely using age-specific formulations. …”

Reconciliation services product value analysis. by Yu Zhang (12946)

“…Rational selection and breeding of economic forest species aid in creating ecolabel brands. This small - watershed - scale analysis improves the accuracy of assessing ecological and economic development in karst areas, providing a scientific basis for decision - making to strengthen ecological restoration and enhance people’s well - being.…”

Data Sheet 2_UrbanAgri: a transfer learning-based plant stress identification framework for sustainable smart urban growth.pdf by Upinder Kaur (10805317)

“…<p>The speed of urbanization around the world is decreasing the arable land endangering food security since the population is estimated to reach 9.7 billion by the year 2050. …”

Table 1_Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity.docx by Bilal Tulumcu (21428903)

“…</p>Results and discussion<p>At 17 years, mean INSL3 is not yet maximal, with high variance due to both longitudinal (timing of pubertal trajectory) and cross-sectional influences, whereas at 24 years, circulating INSL3 concentration has stabilized to its final adult status, even showing a small decreasing trend with age. Maximal INSL3 (i.e., peak puberty) was calculated to be at approximately 22 years in this cohort. …”

Means of sampling data in the Shibing study area. by Yu Zhang (12946)

“…Rational selection and breeding of economic forest species aid in creating ecolabel brands. This small - watershed - scale analysis improves the accuracy of assessing ecological and economic development in karst areas, providing a scientific basis for decision - making to strengthen ecological restoration and enhance people’s well - being.…”

Technology roadmap. by Yu Zhang (12946)

“…Rational selection and breeding of economic forest species aid in creating ecolabel brands. This small - watershed - scale analysis improves the accuracy of assessing ecological and economic development in karst areas, providing a scientific basis for decision - making to strengthen ecological restoration and enhance people’s well - being.…”

Image 3_The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.tif by Zechen Zhang (11702123)

“…C-terminal telopeptide (CTX) showed a small, statistically significant reduction (MD −0.09, 95% CI −0.14 to −0.05) with uncertain clinical relevance. …”

Astrocyte morphology is altered by stretch-induced downregulation of S100B expression. by Weiran Huang (8934899)

“…On occasion, cells were small in shape and poorly extended (c). Scale bar: 100 μm. …”

Table 3_Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity.docx by Bilal Tulumcu (21428903)

“…</p>Results and discussion<p>At 17 years, mean INSL3 is not yet maximal, with high variance due to both longitudinal (timing of pubertal trajectory) and cross-sectional influences, whereas at 24 years, circulating INSL3 concentration has stabilized to its final adult status, even showing a small decreasing trend with age. Maximal INSL3 (i.e., peak puberty) was calculated to be at approximately 22 years in this cohort. …”

Value ranges of three representative points. by Bin Zhao (276445)

“…Numerical experiments using actual survey data from Kunshan City yield several noteworthy findings: (1) An optimal moderate-sized time step exists for rolling optimization to minimize either the average delay time or total costs; specifically, an excessively small time step may increase vehicle average delay time or total costs; (2) The percentage of delay reduction achieved by our method, compared to Synchro software, reaches a maximum of approximately 70% when traffic demand is moderate and the initial state is low; and (3) The percentage reduction in average delay or total costs compared to Synchro initially increases and then decreases with rising traffic intensity.…”

Image 4_A putative glucose-1-phosphate thymidylyltransferase is required for virulence, membrane-associated mechanisms, and tolerance to external stresses in Acidovorax citrulli.ti... by Junhyeok Choi (14078586)

“…This study provides novel insights into the role of GptTAc in the virulence of Ac, which may facilitate the identification of antivirulence agents targeting GptTAc by screening small-molecule and natural product libraries in order to control BFB.…”

Signalized intersection in Kunshan. by Bin Zhao (276445)

“…Numerical experiments using actual survey data from Kunshan City yield several noteworthy findings: (1) An optimal moderate-sized time step exists for rolling optimization to minimize either the average delay time or total costs; specifically, an excessively small time step may increase vehicle average delay time or total costs; (2) The percentage of delay reduction achieved by our method, compared to Synchro software, reaches a maximum of approximately 70% when traffic demand is moderate and the initial state is low; and (3) The percentage reduction in average delay or total costs compared to Synchro initially increases and then decreases with rising traffic intensity.…”

Roxadustat alleviates cisplatin-induced acute kidney injury by regulating fatty acid oxidation and mitochondrial function by Xialin Li (20449207)

“…<p>This study aimed to elucidate the role and function of roxadustat, a small molecule hypoxia-inducible factor (HIF) stabilizer, on cisplatin-induced acute kidney injury (AKI) <i>in vivo</i> and <i>in vitro</i>.…”

Dynamic system state in demand scenarios 2. by Bin Zhao (276445)

“…Numerical experiments using actual survey data from Kunshan City yield several noteworthy findings: (1) An optimal moderate-sized time step exists for rolling optimization to minimize either the average delay time or total costs; specifically, an excessively small time step may increase vehicle average delay time or total costs; (2) The percentage of delay reduction achieved by our method, compared to Synchro software, reaches a maximum of approximately 70% when traffic demand is moderate and the initial state is low; and (3) The percentage reduction in average delay or total costs compared to Synchro initially increases and then decreases with rising traffic intensity.…”

Image 1_The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.tif by Zechen Zhang (11702123)

“…C-terminal telopeptide (CTX) showed a small, statistically significant reduction (MD −0.09, 95% CI −0.14 to −0.05) with uncertain clinical relevance. …”

Table 1_Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov.xlsx by Yinghong Zhou (6873053)

“…</p>Conclusion<p>In the last ten years, registered pediatric drug trials have either stayed stable or slightly decreased, often featuring small sample sizes and rarely using age-specific formulations. …”

Image 1_A putative glucose-1-phosphate thymidylyltransferase is required for virulence, membrane-associated mechanisms, and tolerance to external stresses in Acidovorax citrulli.ti... by Junhyeok Choi (14078586)

“…This study provides novel insights into the role of GptTAc in the virulence of Ac, which may facilitate the identification of antivirulence agents targeting GptTAc by screening small-molecule and natural product libraries in order to control BFB.…”