Published 2025
“…<p>a) Fitted data on fold changes show a) a 36% increase in LVM [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref015" target="_blank">15</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref016" target="_blank">16</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref020" target="_blank">20</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref033" target="_blank">33</a>] and b) 67% increase in LV end-
diastolic volume (V<sub><i>ED</i></sub>) [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref016" target="_blank">16</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref017" target="_blank">17</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref020" target="_blank">20</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref026" target="_blank">26</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref029" target="_blank">29</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref032" target="_blank">32</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref033" target="_blank">33</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref061" target="_blank">61</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref078" target="_blank">78</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref080" target="_blank">80</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref082" target="_blank">82</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref083" target="_blank">83</a>,<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref131" target="_blank">131</a>–<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012390#pcbi.1012390.ref136" target="_blank">136</a>] on average at steady-state. c) In a spherical model, these changes imply a 20% increase followed by a gradual
decrease below baseline in end-
diastolic strain on average, with a wide range of trajectories possible for different combinations of mass and
volume change. d) Calculated chronic strain levels are lower when LVM increases more. …”