Structure–Activity Relationships and Discovery of (<i>S</i>)‑5‑(<i>tert</i>-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2′,1′:2,3]imidazo[4,5‑<i>h</i>]quin... by Dimitar Gotchev (1893928)

“…Optimization of a novel series of PAPD5/7 inhibitors that decrease HBsAg levels led to the tetracyclic 2-pyridone <b>AB-161</b>, which was similarly potent to <b>AB-452</b> <i>in vitro</i> and <i>in vivo</i> but showed dramatically higher rodent liver-to-plasma ratios. …”

Data Sheet 1_Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study.pdf by Xiao-Qiang Han (596982)

“…Compared with the LP group, the relative abundances of Prevotella, Erysipelotrichaceae_UCG-003, and Dorea were increased dramatically in the PE group, whereas the relative abundances of Subdoligranulum, Parabacteroides, Bacteroides were significantly decreased in the PE group. …”

Data Sheet 1_Thermodynamic integration in combined fuel and power plants producing low carbon hydrogen and power with CCUS.docx by Daniel Mullen (5681870)

“…<p>Demand for low-carbon sources of hydrogen and power is expected to rise dramatically in the coming years. Individually, steam methane reformers (SMRs) and combined cycle gas power plants (CCGTs), when combined with carbon capture utilisation and storage (CCUS), can produce large quantities of on-demand decarbonised hydrogen and power respectively. …”

Supplementary Material for: Effect of Surface Perturbation Treadmill Training Program on Strategies and Kinematics of Reactive Stepping during Standing in Older Adults: A Single-Bl... by figshare admin karger (2628495)

“…Introduction: perturbation-based balance training reduces fall rates dramatically by triggering and improving balance recovery skills. …”

Additional file 1 of Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction by Feng Shao (112229)

“…Beating rates of CMs decrease dramatically in NDPKB-depleted hiPSC-CMs. …”

Data inputs for BKMR. by Xiaojing Zeng (2577715)

“…Over the past two decades, China has dramatically reduced maternal mortality in more developed (eastern) and less developed (western) regions. …”

Effects of activators and inhibitors on TcPiezo channels. by Guozhong Huang (673424)

“…Addition of 20 µ M Yoda1 (+Yoda1) dramatically stimulated TcPiezo2-mediated Ca²⁺ release from lysosomes. …”

Robust chain-length specific reductions in some intermediate chain and long chain PE phospholipids in peroxisomal mutant brain. by Michael F. Wangler (21526595)

“…</b> Levels in mol% of PE 33:3 in <i>pex2</i> and <i>pex16</i> mutant brains show significant decreases in <i>pex</i> mutant brains. For PE 33:3 in <i>pex2</i>² brain and <i>pex2</i>^<i>1</i> brain, levels are dramatically reduced compared to controls (ratio 0.225, 0.200 respectively, p < 0.001, p < 0.001 respectively) and <i>pex2</i>^<i>2</i> brain compared to rescue (ratio 0.244, p < 0.001), and <i>pex2</i>^<i>1</i> compared to rescue (ratio 0.220, p < 0.001). …”

Image 2_Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.tif by Fengge Wang (4347442)

“…Compared to the control rats, GDM rats showed a significantly higher abundance of Blautia and Anaerobiospirillum. However, the dramatically elevated abundance of these microorganisms was markedly decreased by AS IV treatment. …”

Image 1_Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.tif by Fengge Wang (4347442)

“…Compared to the control rats, GDM rats showed a significantly higher abundance of Blautia and Anaerobiospirillum. However, the dramatically elevated abundance of these microorganisms was markedly decreased by AS IV treatment. …”

Table 1_Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.xlsx by Fengge Wang (4347442)

“…Compared to the control rats, GDM rats showed a significantly higher abundance of Blautia and Anaerobiospirillum. However, the dramatically elevated abundance of these microorganisms was markedly decreased by AS IV treatment. …”

Table 2_Astragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.xlsx by Fengge Wang (4347442)

“…Compared to the control rats, GDM rats showed a significantly higher abundance of Blautia and Anaerobiospirillum. However, the dramatically elevated abundance of these microorganisms was markedly decreased by AS IV treatment. …”

SPOP is required for adipocyte differentiation. by Qinghe Li (221930)

“…Oil red O staining of the lipid droplet showed that the efficiency of adipocytes differentiation in the <i>SPOP</i> knockout cells was dramatically decreased compared with the wild-type control cells. d, The triglyceride levels in the primary adipocytes after <i>SPOP</i> knockout. e, The mRNA expression levels of genes involved in adipogenesis and proliferation.…”

Supplementary file 1_Interspecific association characteristics of Alternanthera philoxeroides-invaded communities and their latitudinal variations.docx by Hao Wu (65943)

“…The ratio of species pairs with positive/negative associations (PNR) in terrestrial communities dramatically decreased at higher latitudes. The values of the Jaccard index (J_A), Ochiai index (O_I), and Dice index (D_I) which represent the interspecific association intensity in terrestrial communities, were extremely significantly greater than those in aquatic communities. …”

Table 1_Association between androgenetic alopecia and psychological well-being: a systematic review and meta-analysis.docx by Yuan Kong (110669)

“…</p>Conclusion<p>AGA patients experience increased levels of symptoms of anxiety, symptoms of depression, stress, body image dissatisfaction, somatization, interpersonal sensitivity, and psychoticism, as well as decreased self-esteem, life satisfaction, emotional intelligence, self-actualization, problem-solving ability, optimism, and happiness. …”

Evaluation of heavy hydrocarbon liquid in the Eastern Dahomey Basin, Southwestern Nigeria (case study of Agbabu Bitumen in Ondo State) by Oluwatoyin O. Akinsete (21633970)

“…Agbabu bitumen was found to have a high content of saturates and aromatics. Viscosity decreases as pressure increases, while solubility reduces as temperature increases. …”

Nerve conduction study and nerve ultrasound as biomarkers for steroid dependence in chronic inflammatory demyelinating polyneuropathy by Jingwen Niu (538210)

“…None of the patients whose MCV improved above the lower normal limit were steroid-dependent, whereas nearly half of those whose MCV decreased or remained unchanged were steroid-dependent (<i>p</i> = 0.005). …”

Data Sheet 1_Soil fungal community and co-occurrence network patterns at different successional stages of black locust coppice stands.docx by Huimei Tian (499744)

“…However, these factors dramatically altered the soil fungal community structure. …”

Table_1_Association between changes in body composition and progression of liver fibrosis in patients with type 2 diabetes mellitus.docx by Yuxi Lin (1809715)

“…</p>Results<p>Among 72 patients with incident advanced liver fibrosis at readmission, ΔBMI, ΔFMI and ΔTFMI increased, while ΔM/F and ΔA/T decreased. Individuals who kept obese had a dramatically elevated hazard of incident advanced liver fibrosis compared to those who kept non-obese, with an adjusted odds ratio of 3.464. …”

Image_1_Association between changes in body composition and progression of liver fibrosis in patients with type 2 diabetes mellitus.tif by Yuxi Lin (1809715)

“…</p>Results<p>Among 72 patients with incident advanced liver fibrosis at readmission, ΔBMI, ΔFMI and ΔTFMI increased, while ΔM/F and ΔA/T decreased. Individuals who kept obese had a dramatically elevated hazard of incident advanced liver fibrosis compared to those who kept non-obese, with an adjusted odds ratio of 3.464. …”