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marked decrease » marked increase (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
b marked » _ marked (Expand Search), n marked (Expand Search), _ market (Expand Search)
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<b>The loss of insulin-positive cell clusters precedes the decrease of islet frequency and beta cell area in type 1 diabetes</b>
Published 2025“…The majority of functional beta cell mass is typically lost within months to years of disease diagnosis, but the timing and nature of this loss, particularly in early disease stages, remain unclear. We developed a whole-slide scanned image (WSI) analysis pipeline for semi-automated quantitation of endocrine areas, islet frequencies, inter-islet distances, and endocrine object size distribution in 145 human pancreata from 60 non-diabetic (ND), 19 single autoantibody positive (sAAb+), 10 multiple autoantibody positive (mAAb+), 16 recent-onset (0-1 year duration), 23 medium-duration (1-7 years), and 17 long-duration type 1 diabetes (7+ years) donors. …”
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