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ROS, K<sup>+</sup> efflux and cathepsin B are required for NLRP3 activation.
Published 2025Subjects: -
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related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs.
Published 2025Subjects: -
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Eggs jointly coordinate a caspase-1 and caspase-8 dependent pyroptotic cell death.
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The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses.
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Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8.
Published 2025Subjects: -
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MEDOC: A Fast, Scalable, and Mathematically Exact Algorithm for the Site-Specific Prediction of the Protonation Degree in Large Disordered Proteins
Published 2025“…To address this problem, we developed "multisite extent of deprotonation originating from context" (MEDOC) to determine the degree of protonation of a protein based on the local sequence context of each ionizable residue. …”
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