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Eggs jointly coordinate a caspase-1 and caspase-8 dependent pyroptotic cell death.
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ROS, K<sup>+</sup> efflux and cathepsin B are required for NLRP3 activation.
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related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs.
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Gsdmd deficiency reduces myeloid cell recruitment to the liver during schistosome infection.
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The loss of NLRP3 and AIM2 results in reduced Th17 and enhanced Th2 cytokine responses.
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Egg-induced IL-1β and IL-17 production is dependent on both Caspase-1 and Caspase-8.
Published 2025Subjects: -
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Morphological changes in the testis and epididymis.
Published 2025“…C & G) PM2.5 rats exhibited sparse germinal layer in the seminiferous tubules, lumenal vacuolation and sperm shedding (black arrow) were observed, and the sperm quantity was significantly decreased. D & H) PM2.5 + Vit rats showed marked increase in sperm density, which improved relative to the PM2.5 rats. …”
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Table 1_Imeglimin may affect hemoglobin A1c accuracy via prolongation of erythrocyte lifespan in patients with type 2 diabetes mellitus: insights from the INFINITY clinical trial.d...
Published 2025“…</p>Results<p>The change in hemoglobin concentration at 6 months was not statistically significant (mean ± SD: −0.2 ± 0.9 g/dL; p = 0.23). While HbA1c and GA decreased and 1,5-AG increased one month after imeglimin initiation, GA and 1,5-AG showed rapid changes compared to the gradual decrease in HbA1c. …”
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Image 1_Using sodium glycodeoxycholate to develop a temporary infant-like gut barrier model, in vitro.pdf
Published 2025“…The treatment also reduced the key tight junction protein, occludin, at the cell membrane, and increased acidic mucins and extracellular alkaline phosphatase activity. Additionally, GDC decreased cAMP, suggesting its mechanism of action was via activation of a G-protein coupled receptor. …”