General procedure for the synthesis of the target compounds 11a,b,15a,b. حسب Ahmed A. Gaber (13302308)

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3D interactions between the ligand and the protein_DNA complex in the first (C1) and second (C2) clusters. حسب Ahmed A. Gaber (13302308)

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ALS patients’ tissues exhibit increased phosphorylation of MARK2. حسب Yu-Ning Lu (10291271)

"…<p>(<b>A</b>) Representative immunoblot analyses of PKCδ, MARK2-⁵⁹⁵T, and eIF2α in the spinal cord tissues from ALS patients and non-ALS controls, indicating that increased phosphorylation of PKCδ-⁵⁰⁵T, MARK2-⁵⁹⁵T, and eIF2α-⁵¹S is a general phenotype in patient tissues. …"

Deletion of Hhp2 markedly increased Sre1 activity. حسب Hao Miao (1742044)

"…<p>Deletion of <i>hhp2</i>⁺ gene markedly increased Sre1 activity in the presence/absence of CLZ (2 μg/ml to 8 μg/ml) (A), TER (2 μg/ml to 8 μg/ml) (B) or CoCl₂ (0.08 mM to 0.32 mM) (C). …"

General procedures for the synthesis of the key compounds 7a, b, 9, and 10. حسب Ahmed A. Gaber (13302308)

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Binding of compound 11a with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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The contributions of amino acids around 10 Å of the ligand to the binding free energy. حسب Ahmed A. Gaber (13302308)

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Binding of compound 12b with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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Chronic colitis induces marked changes in protein expression in the adult heart and blood. حسب Yanbo Tang (11457519)

"…(B) Arbitrary optical density units of the targeting proteins were normalized <i>vs</i>. α-Actin and presented as fold change. (C) Immunostaining of COL3A1 in heart sections showing COL3A1 accumulation in DSS rats. …"

Binding of compound 16 with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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Binding of amsacrine with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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The center of mass distances between the protein-DNA complex and the ligand (Blue line), and the protein and DNA (red line). حسب Ahmed A. Gaber (13302308)

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Fig 12 - حسب Ahmed A. Gaber (13302308)

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Effect of compound 16 on stages of the cell death process in HCT-116 cells after 48 h treatment. حسب Ahmed A. Gaber (13302308)

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General procedure for the synthesis of the target compounds 16–20. حسب Ahmed A. Gaber (13302308)

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The number of clusters, number of interactions, and their types between the ligand and protein_DNA complex. حسب Ahmed A. Gaber (13302308)

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Binding of compound 17 with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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Effect of compound 16 on the levels of BAX, and Bcl-2 proteins expression in HCT-116 cells treated for48 h. حسب Ahmed A. Gaber (13302308)

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Effect of compound 16 on cell cycle progression in HCT-116 cells after 48h treatment. حسب Ahmed A. Gaber (13302308)

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Fig 4 - حسب Ahmed A. Gaber (13302308)

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