Schematic overview of SINATRA Pro: A novel framework for discovering biophysical signatures that differentiate classes of proteins. by Wai Shing Tang (9541179)

“…<p><b>(A)</b> The SINATRA Pro algorithm requires the following inputs: <i>(i)</i> (<i>x</i>, <i>y</i>, <i>z</i>)-coordinates corresponding to the structural position of each atom in every protein; <i>(ii)</i> <b>y</b>, a binary vector denoting protein class or phenotype (e.g., mutant versus wild-type); <i>(iii)</i> <i>r</i>, the cutoff distance for simplicial construction (i.e., constructing the mesh representation for every protein); <i>(iv)</i> <i>c</i>, the number of cones of directions; <i>(v)</i> <i>d</i>, the number of directions within each cone; <i>(vi)</i> <i>θ</i>, the cap radius used to generate directions in a cone; and <i>(vii)</i> <i>l</i>, the number of sublevel sets (i.e., filtration steps) used to compute the differential Euler characteristic (DEC) curve along a given direction. …”

PathOlOgics_RBCs Python Scripts.zip by Ahmed Elsafty (16943883)

“…This process generated a ground-truth binary semantic segmentation mask and determined the bounding box coordinates (XYWH) for each cell. …”