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kinase target » single target (Expand Search)
target based » target area (Expand Search)
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Optimized Bayesian regularization-back propagation neural network using data-driven intrusion detection system in Internet of Things
Published 2025“…Hence, Binary Black Widow Optimization Algorithm (BBWOA) is proposed in this manuscript to improve the BRBPNN classifier that detects intrusion precisely. …”
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Identification of Optimal Machine Learning Algorithms and Molecular Fingerprints for Explainable Toxicity Prediction Models Using ToxCast/Tox21 Bioassay Data
Published 2024“…This study aimed to identify the optimal combination of molecular fingerprints (pattern-based versus algorithm-based) and machine learning algorithms (simple versus complex) for developing explainable toxicity prediction models through an comprehensive investigation of the ToxCast/Tox21 bioassay data set. …”
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Bayesian sequential design for sensitivity experiments with hybrid responses
Published 2023“…To deal with the problem of complex computation involved in searching for optimal designs, fast algorithms are presented using two strategies to approximate the optimal criterion, denoted as SI-optimal design and Bayesian D-optimal design, respectively. …”
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DataSheet1_Implementing a Scoring Function Based on Interaction Fingerprint for Autogrow4: Protein Kinase CK1δ as a Case Study.ZIP
Published 2022“…A class of targets that have proven to be particularly suitable for this method is represented by kinases, as demonstrated by the approval of BRAF inhibitor vemurafenib. …”
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Discovery of Vascular Endothelial Growth Factor Receptor 2 Inhibitors Employing Junction Tree Variational Autoencoder with Bayesian Optimization and Gradient Ascent
Published 2024“…In the development of anticancer medications, vascular endothelial growth factor receptor 2 (VEGFR-2), which belongs to the protein tyrosine kinase family, emerges as one of the most significant targets of interest. …”
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DataSheet1_Machine learning-based prediction model for the efficacy and safety of statins.docx
Published 2024“…Ultimately, an accessible web-based platform for predicting statin efficacy and safety was established based on the optimal predictive model.…”
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DataSheet1_Determination of a prediction model for therapeutic response and prognosis based on chemokine signaling-related genes in stage I–III lung squamous cell carcinoma.docx
Published 2022“…The TCIA database and pRRophetic algorithm were utilized to predict responses to immunochemotherapy and targeted therapy.…”
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Table 1_The potential role of next-generation sequencing in identifying MET amplification and disclosing resistance mechanisms in NSCLC patients with osimertinib resistance.xlsx
Published 2024“…Purposes<p>Osimertinib, one of the third-generation EGFR-tyrosine kinase inhibitors (TKIs) designed to target EGFR T790M mutation, significantly improves the prognosis of lung cancer. …”