Data Sheet 1_Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration.docx by Viola Niemann (22572638)

“…Critical pathomechanisms involve immune cell infiltration and degradation of the vascular extracellular matrix (ECM). Hyaluronan (HA), a major constituent of the ECM synthesized by three HA synthase isoenzymes (HAS1-3), plays a role in both processes. …”

Table1_Application of hydrological model to simulate streamflow contribution on water balance in Himalaya river basin, Nepal.docx by Bhumi Raj Budhathoki (15774980)

“…Runoff components contribution to streamflow was increasing but water storage changes was decreasing in recent decade (2011–2020). We believe our findings are crucial for future initiatives involving water resources, water-induced disaster management, and studies of climate change may benefit from the findings of this study, especially in a region with limited hydrometric data availability.…”

Video_1_Diurnal Differences in Intracellular Replication Within Splenic Macrophages Correlates With the Outcome of Pneumococcal Infection.mp4 by Ryan G. Hames (12715985)

“…Pneumococcal clusters within MMMs were more abundant and increased in size over time in active phase-infected mice compared to those in rest phase-infected mice which decreased in size and were present in a lower percentage of MMMs. …”

LGG-1 foci formation following UV irradiation in hermaphrodite and male gonads. by Hyemin Min (6733586)

“…The non-irradiated gonad appeared not different from the one at the 0.5 h time point. (4 h) The number of LGG-1 foci decreased compared to the 3 h time point, and PGL-1 was removed from a significant number of germ cells (arrowheads) in the UV-irradiated gonad. …”

Table 1_Integrated multi-omics analysis reveals the mechanisms of naringin in ameliorating high-fat diet-induced metabolic dysfunction-associated steatotic liver disease.doc by Wenping Sun (1465360)

“…However, its underlying mechanisms remain largely elusive.</p>Methods<p>In this study, we investigated the efficacy and underlying mechanisms of Nar in a mouse model of high-fat diet (HFD)-induced MASLD using integrated analyses of network pharmacology, molecular docking, hepatic lipidomics, and gut microbiota.…”

DataSheet2_The impact of violating the independence assumption in meta-analysis on biomarker discovery.PDF by Farnoosh Abbas-Aghababazadeh (5917085)

“…Importantly, we show that violating the independence assumption decreases the generalizability of the biomarker discovery process and increases false positive results, a key challenge in precision oncology.…”

DataSheet1_The impact of violating the independence assumption in meta-analysis on biomarker discovery.pdf by Farnoosh Abbas-Aghababazadeh (5917085)

“…Importantly, we show that violating the independence assumption decreases the generalizability of the biomarker discovery process and increases false positive results, a key challenge in precision oncology.…”

Spatiotemporal Distribution, Sources, and Photobleaching Imprint of Dissolved Organic Matter in the Yangtze Estuary and Its Adjacent Sea Using Fluorescence and Parallel Factor Anal... by Penghui Li (759754)

“…By contrast, two protein-like components fell below the theoretical mixing line, largely due to microbial degradation and removal during mixing. …”

Deficiency of the UBE2C/F264 Axis Underlies Intrinsic Radioresistance in Cervical Carcinoma by Maowei Ni (15397932)

“…Intrinsic radiotherapy resistance remains a persistent challenge to the treatment of cervical cancer (CC), as the underlying mechanisms remain largely elusive. …”

Table_1_HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation.pdf by Francesca Sardina (9382625)

“…We found that HIPK2 depletion leads to (i) increased levels of CEP55, a key effector of both midbody formation and MBR degradation; (ii) decreased levels of the selective autophagy receptors NBR1 and p62/SQSTM1; and (iii) impaired autophagic flux. …”

Rapid Buildup of Genetic Diversity in Founder Populations of the Gynodioecious Plant Species <i>Origanum vulgare</i> after Semi-Natural Grassland Restoration by Kenny Helsen (424033)

“…<div><p>In most landscapes the success of habitat restoration is largely dependent on spontaneous colonization of plant species. …”

Data_Sheet_1_The Vacuolar Molybdate Transporter OsMOT1;2 Controls Molybdenum Remobilization in Rice.PDF by Dawei Hu (2186113)

“…In this study, we characterized the functions of a molybdate transporter, OsMOT1;2, in the interorgan allocation of Mo in rice. …”

Data_Sheet_1_Distribution, community structure and assembly patterns of phytoplankton in the northern South China Sea.DOCX by Jian Zou (248686)

“…<p>A cruise was conducted in the summer of 2023 from the Pearl River Estuary (PRE) to the adjacent waters of the Xisha Islands in the northern South China Sea (NSCS) to investigate the distribution, community structure, and assembly patterns of eukaryotic and prokaryotic phytoplankton using high-throughput sequencing (HTS) and microscopic observation. …”

Data_Sheet_2_The Nuclear Farnesoid X Receptor Reduces p53 Ubiquitination and Inhibits Cervical Cancer Cell Proliferation.docx by Xiaohua Huang (280302)

“…<p>The role of farnesoid X receptor (FXR) in cervical cancer and the underlying molecular mechanism remain largely unknown. Therefore, this study aimed to assess the mechanism of FXR in cervical cancer. …”

Data_Sheet_1_BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway.docx by Jun Yu (5904)

“…<p>Testosterone biosynthesis progressively decreases in aging males primarily as a result of functional changes to Leydig cells. …”

Role of LRRK2 in the regulation of dopamine receptor trafficking by Mauro Rassu (4068670)

“…Up to date, the role of LRRK2 in PD onset and progression remains largely unknown. However, experimental evidence highlights a critical role of LRRK2 in the control of vesicle trafficking that in turn may regulate different aspects of neuronal physiology. …”

Persistent fibrosis, hypertrophy and sarcomere disorganisation after endoscopy-guided heart resection in adult <i>Xenopus</i> by Lindsey Marshall (3826567)

“…Our work suggests that, contrary to urodeles and teleosts, with the exception of medaka, adult anurans share a cardiac injury outcome similar to adult mammals. …”

DataSheet1_The impact of violating the independence assumption in meta-analysis on biomarker discovery.pdf by Farnoosh Abbas-Aghababazadeh (5917085)

“…Importantly, we show that violating the independence assumption decreases the generalizability of the biomarker discovery process and increases false positive results, a key challenge in precision oncology.…”

Image_3_HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation.TIF by Francesca Sardina (9382625)

“…We found that HIPK2 depletion leads to (i) increased levels of CEP55, a key effector of both midbody formation and MBR degradation; (ii) decreased levels of the selective autophagy receptors NBR1 and p62/SQSTM1; and (iii) impaired autophagic flux. …”

Acute Heat Stress and Reduced Nutrient Intake Alter Intestinal Proteomic Profile and Gene Expression in Pigs by Sarah C. Pearce (440274)

“…Heat stress reduced ileum abundance of several metabolic enzymes, many of which are involved in the glycolytic or TCA pathways, indicating a change in metabolic priorities. Stress response enzymes peroxiredoxin-1 and peptidyl-prolyl cis-trans isomerase A were decreased in pair-fed thermal neutral and thermal neutral pigs compared to heat stress. …”