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Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, with Decreased Expression of Growth Hormone-Releasing Hormone in the Hypothalamus
Published 2021“…Plasma GH and IGF-1 levels were also lower in the NIrs1KO mice. The expression levels of GHRH protein in the median eminence, where Irs1 antibody staining is observed, were markedly decreased in the NIrs1KO mice. …”
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Data_Sheet_1_Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids.pdf
Published 2022“…Human dorsal forebrain organoids were used to recapitulate course of cortical neurogenesis in the developing human brain. Combining morphological characterization with massive parallel RNA sequencing (RNA-seq) on organoids to analyze the pathogenic effects caused by VPA exposure and critical signaling pathway. …”
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The combination of LPS and PFC caused faster clot initiation and decreased clot strength.
Published 2022Subjects: -
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The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients.
Published 2020“…Results show that, in normal crypts, the distribution and proportion of cells staining for ALDH1 and CGA are very similar. In contrast, in <i>APC</i>-mutant tissues from FAP patients, the proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases. …”
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Data_Sheet_1_Immune and Neuroendocrine Trait and State Markers in Psychotic Illness: Decreased Kynurenines Marking Psychotic Exacerbations.docx
Published 2020“…Increased CRP, CCL2, and IL1RA, and decreased KA and KA/Kyn are trait markers of psychotic illness.…”
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