ALS patients’ tissues exhibit increased phosphorylation of MARK2. by Yu-Ning Lu (10291271)

“…<p>(<b>A</b>) Representative immunoblot analyses of PKCδ, MARK2-⁵⁹⁵T, and eIF2α in the spinal cord tissues from ALS patients and non-ALS controls, indicating that increased phosphorylation of PKCδ-⁵⁰⁵T, MARK2-⁵⁹⁵T, and eIF2α-⁵¹S is a general phenotype in patient tissues. …”

Deletion of Hhp2 markedly increased Sre1 activity. by Hao Miao (1742044)

“…<p>Deletion of <i>hhp2</i>⁺ gene markedly increased Sre1 activity in the presence/absence of CLZ (2 μg/ml to 8 μg/ml) (A), TER (2 μg/ml to 8 μg/ml) (B) or CoCl₂ (0.08 mM to 0.32 mM) (C). …”

General procedure for the synthesis of the target compounds 11a,b,15a,b. by Ahmed A. Gaber (13302308)

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3D interactions between the ligand and the protein_DNA complex in the first (C1) and second (C2) clusters. by Ahmed A. Gaber (13302308)

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Withdrawal of Type I JAKinibs increased STAT phosphorylation, a phenomenon present but markedly lower in Type II JAKinibs. by Ilya Gurevic (1326786)

“…(A) pJAK2 peaked at time zero after exposure to baricitinib and ruxolitinib and then decreases. …”

Binding of compound 11a with DNA-Topo II complex. by Ahmed A. Gaber (13302308)

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Non-permissive chromatin marks increase in the surviving population after T cell stimulation. by Birgitta Lindqvist (8378349)

PLB is a target gene of miRNA 221. by Hongyu Li (1332669)

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General procedures for the synthesis of the key compounds 7a, b, 9, and 10. by Ahmed A. Gaber (13302308)

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The contributions of amino acids around 10 Å of the ligand to the binding free energy. by Ahmed A. Gaber (13302308)

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Increased phosphorylation of MARK2 occurs in the affected tissues of a mutant SOD1-induced ALS mouse model. by Yu-Ning Lu (10291271)

“…The staining of phosphorylated MARK2-⁵⁹⁵T in all 3 brain regions is increased in the SOD1^G93A mice as compared to NTg mice. …”

Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis by Kristina M. Garske (11220178)

“…In summary, we identify LRIs that mark repressed regions of the genome, and these interactions increase across adipogenesis, pinpointing developmental regions that need to be repressed in a cell-type specific way for adipogenesis to proceed.…”

Chronic colitis induces marked changes in protein expression in the adult heart and blood. by Yanbo Tang (11457519)

“…(C) Immunostaining of COL3A1 in heart sections showing COL3A1 accumulation in DSS rats. …”

MS decreases the larger amplitude distribution in adult rats. by Jesús David Ayala-Rodríguez (17364296)

Binding of compound 16 with DNA-Topo II complex. by Ahmed A. Gaber (13302308)

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Binding of amsacrine with DNA-Topo II complex. by Ahmed A. Gaber (13302308)

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The center of mass distances between the protein-DNA complex and the ligand (Blue line), and the protein and DNA (red line). by Ahmed A. Gaber (13302308)

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Fig 12 - by Ahmed A. Gaber (13302308)

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Effect of compound 16 on stages of the cell death process in HCT-116 cells after 48 h treatment. by Ahmed A. Gaber (13302308)

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General procedure for the synthesis of the target compounds 16–20. by Ahmed A. Gaber (13302308)

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