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large decrease » marked decrease (Expand Search), large increases (Expand Search), large degree (Expand Search)
c large » _ large (Expand Search), i large (Expand Search), _ larger (Expand Search)
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Image_1_Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development.jpeg
Published 2024“…</p>Discussion<p>Our results prove that angpt1 and itgb1b, besides regulating vascular development, act as a neurogenic factor via notch and wnt signaling pathways in the neural proliferation zone in the developing brain, indicating a novel role of dual regulation of angpt1 in embryonic neurogenesis that supports the concept of angiopoietin-based therapeutics in neurological disorders.…”
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82
Image_2_Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development.jpeg
Published 2024“…</p>Discussion<p>Our results prove that angpt1 and itgb1b, besides regulating vascular development, act as a neurogenic factor via notch and wnt signaling pathways in the neural proliferation zone in the developing brain, indicating a novel role of dual regulation of angpt1 in embryonic neurogenesis that supports the concept of angiopoietin-based therapeutics in neurological disorders.…”
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83
Complement evasion factor (CEF), a novel immune evasion factor of <i>Streptococcus pyogenes</i>
Published 2022“…We have identified an open reading frame (<i>spy0136</i>) in the <i>S. pyogenes</i> SF370 genome encoding a protein of unknown function. Using recombinant Spy0136 in a pull-down assay with human plasma and ELISA, we have identified four complement proteins (C1r, C1s, C3, and C5) as binding partners. …”
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Data_Sheet_1_Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development.pdf
Published 2024“…</p>Discussion<p>Our results prove that angpt1 and itgb1b, besides regulating vascular development, act as a neurogenic factor via notch and wnt signaling pathways in the neural proliferation zone in the developing brain, indicating a novel role of dual regulation of angpt1 in embryonic neurogenesis that supports the concept of angiopoietin-based therapeutics in neurological disorders.…”
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85
Image1_PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization.tif
Published 2021“…<p>Ulcerative colitis (UC) is a form of inflammatory bowel disease, which manifests as irritation or swelling and sores in the large intestine in a relapsing and remitting manner. …”
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Image2_PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization.tif
Published 2021“…<p>Ulcerative colitis (UC) is a form of inflammatory bowel disease, which manifests as irritation or swelling and sores in the large intestine in a relapsing and remitting manner. …”
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Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice
Published 2021“…Mechanistically, we found that inhibition of autophagy led to NLRP3 (NLR family pyrin domain containing 3) inflammasome activation <i>via</i> PDE10A (phosphodiesterase 10A)–cyclic adenosine monophosphate (cAMP) signaling in microglia, and the sequential upregulation of downstream IL1B/IL-1β in turn increased the expression of MIF (macrophage migration inhibitory factor [glycosylation-inhibiting factor]), a pro-inflammatory cytokine. …”