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largest decrease » larger decrease (Expand Search)
marked decrease » marked increase (Expand Search)
c largest » _ largest (Expand Search), c large (Expand Search)
b marked » _ marked (Expand Search), a marked (Expand Search), n marked (Expand Search)
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<b>Effect of Marked Weight Loss on Adipose Tissue Biology in People with Obesity and Type 2 Diabetes</b>
Published 2025“…</p><p dir="ltr"><b>Results: </b>Weight loss: <a href="" target="_blank">i) </a><a href="" target="_blank">decreased adipose tissue </a>expression of genes related to extracellular matrix remodeling; ii) decreased adipose tissue expression of SERPINE 1 which encodes plasminogen activator inhibitor-1 (PAI-1); iii) did not decrease adipose tissue immune cell content or expression of genes involved in inflammation; iv) decreased adipose tissue ceramide content; v) decreased plasma <a href="" target="_blank">PAI-1 </a>and leptin concentrations and increased plasma high-molecular weight (HMW) adiponectin; and vi) decreased plasma small extracellular vesicle (sEV) concentration and the sEV content of microRNAs proposed to inhibit insulin action, and completely reversed the inhibitory effect of plasma sEVs on insulin signaling in myotubes.…”
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ROS, K<sup>+</sup> efflux and cathepsin B are required for NLRP3 activation.
Published 2025Subjects: -
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related to Fig 4. ROS, K+ efflux and cathepsin B do not affect TNFα production in response to eggs.
Published 2025Subjects: -
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