ALS patients’ tissues exhibit increased phosphorylation of MARK2. حسب Yu-Ning Lu (10291271)

"…<p>(<b>A</b>) Representative immunoblot analyses of PKCδ, MARK2-⁵⁹⁵T, and eIF2α in the spinal cord tissues from ALS patients and non-ALS controls, indicating that increased phosphorylation of PKCδ-⁵⁰⁵T, MARK2-⁵⁹⁵T, and eIF2α-⁵¹S is a general phenotype in patient tissues. …"

Deletion of Hhp2 markedly increased Sre1 activity. حسب Hao Miao (1742044)

"…<p>Deletion of <i>hhp2</i>⁺ gene markedly increased Sre1 activity in the presence/absence of CLZ (2 μg/ml to 8 μg/ml) (A), TER (2 μg/ml to 8 μg/ml) (B) or CoCl₂ (0.08 mM to 0.32 mM) (C). …"

General procedure for the synthesis of the target compounds 11a,b,15a,b. حسب Ahmed A. Gaber (13302308)

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3D interactions between the ligand and the protein_DNA complex in the first (C1) and second (C2) clusters. حسب Ahmed A. Gaber (13302308)

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Withdrawal of Type I JAKinibs increased STAT phosphorylation, a phenomenon present but markedly lower in Type II JAKinibs. حسب Ilya Gurevic (1326786)

"…(A) pJAK2 peaked at time zero after exposure to baricitinib and ruxolitinib and then decreases. …"

Binding of compound 11a with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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Non-permissive chromatin marks increase in the surviving population after T cell stimulation. حسب Birgitta Lindqvist (8378349)

PLB is a target gene of miRNA 221. حسب Hongyu Li (1332669)

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General procedures for the synthesis of the key compounds 7a, b, 9, and 10. حسب Ahmed A. Gaber (13302308)

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The contributions of amino acids around 10 Å of the ligand to the binding free energy. حسب Ahmed A. Gaber (13302308)

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Increased phosphorylation of MARK2 occurs in the affected tissues of a mutant SOD1-induced ALS mouse model. حسب Yu-Ning Lu (10291271)

"…The staining of phosphorylated MARK2-⁵⁹⁵T in all 3 brain regions is increased in the SOD1^G93A mice as compared to NTg mice. …"

Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis حسب Kristina M. Garske (11220178)

"…In summary, we identify LRIs that mark repressed regions of the genome, and these interactions increase across adipogenesis, pinpointing developmental regions that need to be repressed in a cell-type specific way for adipogenesis to proceed.…"

Chronic colitis induces marked changes in protein expression in the adult heart and blood. حسب Yanbo Tang (11457519)

"…<p>(A) Expression levels of proteins indicated in the tissue lysates of myocardium were significantly altered by DSS-induced chronic colitis. …"

Binding of compound 16 with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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Binding of amsacrine with DNA-Topo II complex. حسب Ahmed A. Gaber (13302308)

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The center of mass distances between the protein-DNA complex and the ligand (Blue line), and the protein and DNA (red line). حسب Ahmed A. Gaber (13302308)

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Fig 12 - حسب Ahmed A. Gaber (13302308)

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Effect of compound 16 on stages of the cell death process in HCT-116 cells after 48 h treatment. حسب Ahmed A. Gaber (13302308)

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General procedure for the synthesis of the target compounds 16–20. حسب Ahmed A. Gaber (13302308)

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The number of clusters, number of interactions, and their types between the ligand and protein_DNA complex. حسب Ahmed A. Gaber (13302308)

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