Impaired Ubr5 function results in increased canonical and decreased non-canonical HH signalling. by David Mellis (2833469)

“…<p>Immunohistochemical analysis of six-week-old control and <i>Ubr5</i>^<i>mt</i> tibial AC examined for markers of canonical HH pathway activity. Relative to (A, C) control, (B, D) <i>Ubr5</i>^<i>mt</i> AC displayed increased staining intensities for PTCH1 (A, B) and GLI1 (C, D) with GLI1 exhibiting expanded expression domains (D, double-headed arrows). …”

<i>Ubr5</i>^<i>mt</i> synovium exhibits markers of increased canonical and decreased non-canonical HH signalling. by David Mellis (2833469)

Overview of the six original ACTIV-3/TICO trials. by Elizabeth S. Munroe (21568166)

IGF-1 does not increase collagen in males. by Patricia Snarski (22305205)

Modifying pregnenolone to decrease its lipophilicity results in decreased cellular uptake. by Jeffrey M. McManus (7512926)

Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis by Kristina M. Garske (11220178)

“…In summary, we identify LRIs that mark repressed regions of the genome, and these interactions increase across adipogenesis, pinpointing developmental regions that need to be repressed in a cell-type specific way for adipogenesis to proceed.…”

Coronavirus replication is decreased in AMPK-knockout (KO) cells. by Minsu Jang (2817730)

The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients. by Tao Zhang (43681)

“…<p>Representative IHC stains of normal, normal-appearing FAP, and FAP adenomatous colonic crypts are shown for the expression of the: <b>(A)</b> NEC marker chromogranin-A (CGA). <b>(B)</b> SC marker ALDH1. …”

Sleep deprivation increased inflammatory cytokines and decreased corticosterone in the blood. by Weiran Shan (16969688)

A summary of the included study characteristics. by Zahra Tajik (20752452)

Subjects:

The analyses of TCGA transcriptome data indicated that an increased expression of SPRR1A predicts a poor prognosis in PDAC patients. by Kohei Yamakawa (3523370)

Subjects:

Open data. by Larissa Brazolotto Ferreira (17671168)

Subjects:

ALS patients’ tissues exhibit increased phosphorylation of MARK2. by Yu-Ning Lu (10291271)

“…Increased phosphorylation of MARK2-⁵⁹⁵T is observed in all ALS patient tissues. …”

IGF-1 increases collagen in mice with myeloid MMP8 reintroduction. by Patricia Snarski (22305205)

Observed range of dental complexity for six genera. by Kiana Christensen (11419667)

Decreased biofilm formation in the Δ<i>tad123</i> mutant cells. by Tra-My Duong-Nu (7300970)

Markers of differentiation are increased in NSCs and markers of pluripotency are decreased. by Natalya A. Ortolano (10291721)

LncRNA H19 promotes osteoclast differentiation by sponging miR-29c-3p to increase expression of CTSK. by Huazhi Li (15391592)

“…Moreover, ovariectomy (OVX) osteoporosis model showed that H19 knockout mice have increased femur bone mineral density (BMD), decreased osteoclast formation, and decreased cathepsin K (CTSK) expression. miR-29c-3p agomir could increase BMD in osteoporotic mice on the premise of H19 knockout. …”

A flow diagram of the study entry. by Sakiko Fukui (387048)

“…Cluster analysis classified 4 clusters of decline in food intake changes during the last 6 months before death: immediate decrease (n = 14); decrease from 1 month before death (n = 24); decrease from 3 months before death (n = 7); and gradual decrease for 6 months before death (n = 24).…”

Induced acetylation of the replication fork increases DNA damage. by Benilde García-de Teresa (17838878)

“…Cells were treated as in Fig 3C, dotted lines mark the nuclei. Differences in the fluorescence of γH2AX among conditions were assessed using the Kruskall Wallis test with Dunn’s post-test for multiple comparisons. …”