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Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties
Published 2025“…In isogenic HCT-116 P53<sup>–/–</sup> cells, <b>14</b> exhibited reduced antiproliferative activity, lower apoptosis, and decreased levels of cleaved Caspase 3, P53, and γH2AX, confirming its P53-dependent mechanism of action linked to DNA damage.…”
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Data Sheet 1_Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements.pdf
Published 2025“…The introduction of an albumin binder (ALB) to radioligands can delay their renal clearance, resulting in increased radioactivity delivered to tumors and decreased renal uptake of radioligands. In this study, we designed novel CA-IX-targeted trifunctional radioligands consisting of imidazothiadiazole sulfonamide (IS) as a CA-IX-targeted ligand, DOTA as a chelator with four free carboxylic groups, and lysine-conjugated 4-(p-iodophenyl)butyric acid (Lys-IPBA) as ALB, with IS-[<sup>111</sup>In]In-DOTADG-ALB in a linear-chain arrangement and [<sup>111</sup>In]In-DOTAGA-ALB-IS in a branched-chain arrangement. …”
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Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls
Published 2025“…Girls’ age of onset puberty has decreased globally in recent years. Emerging evidence suggests that exposure to phthalate esters (PAEs) could play a role in this trend. …”
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Distribution of individual change in trust in science before and after the pandemic (n = 10,000).
Published 2025Subjects: -
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