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linked decrease » marked decrease (Expand Search)
linear decrease » linear increase (Expand Search)
latest decrease » largest decrease (Expand Search), greatest decrease (Expand Search), largest decreases (Expand Search)
_ latest » _ latent (Expand Search), _ largest (Expand Search), _ late (Expand Search)
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Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties
Published 2025“…In isogenic HCT-116 P53<sup>–/–</sup> cells, <b>14</b> exhibited reduced antiproliferative activity, lower apoptosis, and decreased levels of cleaved Caspase 3, P53, and γH2AX, confirming its P53-dependent mechanism of action linked to DNA damage.…”
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Data Sheet 1_Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements.pdf
Published 2025“…The introduction of an albumin binder (ALB) to radioligands can delay their renal clearance, resulting in increased radioactivity delivered to tumors and decreased renal uptake of radioligands. In this study, we designed novel CA-IX-targeted trifunctional radioligands consisting of imidazothiadiazole sulfonamide (IS) as a CA-IX-targeted ligand, DOTA as a chelator with four free carboxylic groups, and lysine-conjugated 4-(p-iodophenyl)butyric acid (Lys-IPBA) as ALB, with IS-[<sup>111</sup>In]In-DOTADG-ALB in a linear-chain arrangement and [<sup>111</sup>In]In-DOTAGA-ALB-IS in a branched-chain arrangement. …”
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Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls
Published 2025“…Girls’ age of onset puberty has decreased globally in recent years. Emerging evidence suggests that exposure to phthalate esters (PAEs) could play a role in this trend. …”
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Descriptive statistics.
Published 2024“…<div><p>While part-time employees constitute the primary workforce in the chain restaurant industry, their retention has become crucial in developed countries, especially Japan, due to labor shortages resulting from the declining birthrate and aging population. …”
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Topics and labels.
Published 2024“…<div><p>While part-time employees constitute the primary workforce in the chain restaurant industry, their retention has become crucial in developed countries, especially Japan, due to labor shortages resulting from the declining birthrate and aging population. …”
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Correlation matrix.
Published 2024“…<div><p>While part-time employees constitute the primary workforce in the chain restaurant industry, their retention has become crucial in developed countries, especially Japan, due to labor shortages resulting from the declining birthrate and aging population. …”
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Theoretical framework.
Published 2025“…<div><p>Background</p><p>The efficient movement of pharmaceuticals through various stakeholders to reach customers in the appropriate quantity and at the right time is achieved through supply chain management. However, the intricate nature of supply chain processes poses tremendous supply chain risks and jeopardizing pharmaceutical manufacturing company’s ability. …”
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Supplementary file survey questioner annex.
Published 2025“…<div><p>Background</p><p>The efficient movement of pharmaceuticals through various stakeholders to reach customers in the appropriate quantity and at the right time is achieved through supply chain management. However, the intricate nature of supply chain processes poses tremendous supply chain risks and jeopardizing pharmaceutical manufacturing company’s ability. …”
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School Food Authority Survey III on Supply Chain Disruption and Student Participation
Published 2025“…<p dir="ltr">In Spring of 2024, the USDA Food and Nutrition Service (FNS) conducted the third survey of supply chain challenges faced by School Food Authorities (SFAs). …”